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• W2897351310 abstract "Background Placement of dental implants has become an essential therapeutic method for the treatment of edentulous or partially edentulous patients. Titanium has been the material of choice for dental implants because of its superior biocompatibility, chemical stability, and mechanical strength. However, bioactivities of titanium substantially decrease when exposed to ambient conditions. Hence, there have been many researches to overcome this limitation by applying various surface modifications. Aim/Hypothesis The present study aimed to compare the cellular attachment, proliferation, and differentiation of osteoblast-like cells and human gingival fibroblasts on titanium discs treated with alendronate immersion and or ultraviolet irradiation. Material and Methods Osteoblast-like cells were cultured on titanium discs with sandblasted, large-grit, acid-etched (SLA) surface, while human gingival fibroblasts were cultured on titanium discs with machined surface (MA). The discs with SLA and machined surface were classified into 4 groups, respectively- (i) no treatment (control), (ii) ultraviolet treatment (UT), (iii) alendronate immersion (AI), (iv) ultraviolet treatment with alendronate immersion (UTAI). WST-1 assay were performed for evaluation of cell proliferation in terms of optical density (OD), and scanning electron microscopy (SEM) were used to analyze cellular attachment. One-way analysis of variance (ANOVA) was conducted to assess the statistical significance of the differences between the groups with the statistical significance level set at α = 0.05. Results A qualitative evaluation on SEM showed a tendency with low cellular attachment for alendronate treated groups regardless of titanium discs with SLA or MA surface. The OD value of solitary application of UT or AI did not show statistically significant differences when compared to the value of control group with regard to the fibroblast cell proliferation. However, further application of AI on the UT had a tendency to decrease fibroblast cell proliferation. With regard to cellular proliferation of osteoblast-like cells, alendronate-treated groups showed a lower cell proliferation compared to non-treated groups. Conclusions and Clinical Implications Alendronate immersion seems to reduce osteoblastic activity which may cause poor bone-to-implant contact. Simultaneous application of ultraviolet irradiation and alendronate immersion may have a potential to negatively affect mucosal sealing. Further studies are needed to identify these effects. Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NO. NRF-2017R1D1A1B03034368)." @default.
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• W2897351310 date "2018-10-01" @default.
• W2897351310 modified "2023-09-23" @default.
• W2897351310 title "Responses of osteoblast-like cells and human gingival fibroblasts to titanium surfaces treated with ultraviolet irradiation and or alendronate immersion" @default.
• W2897351310 doi "https://doi.org/10.1111/clr.83_13358" @default.
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