Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897361250> ?p ?o ?g. }
- W2897361250 endingPage "3242" @default.
- W2897361250 startingPage "3242" @default.
- W2897361250 abstract "Type 1 diabetes (T1DM) is associated with increased cardiovascular disease (CVD) and reduced life expectancy. We thus hypothesized that anti-angiogenic miRs are increased in T1DM, and the cardioprotective effect of metformin is mediated via reducing those miRs. In an open label, case-controlled study, 23 T1DM patients without CVD were treated with metformin for eight weeks (TG), matched with nine T1DM patients on standard treatment (SG) and 23 controls (CG). Plasma miR-222, miR-195, miR-21a and miR-126 were assayed by real-time RT-qPCR. The results were correlated with: endothelial function (RHI), circulating endothelial progenitor cells (cEPCs) (vascular repair marker, CD45dimCD34+VEGFR2+ cells) and circulating endothelial cells (cECs) (vascular injury marker, CD45dimCD34+CD133-CD144+ cells). miR-222, miR-195 and miR-21a were higher in T1DM than CG; p = 0.009, p < 0.0001, p = 0.0001, respectively. There was an inverse correlation between logmiR-222 and logRHI (p < 0.05) and a direct correlation between logmiR-222 and logCD34+ (p < 0.05) in TG. Metformin reduced miR-222, miR-195 and miR-21a levels in TG; p = 0.007, p = 0.002 p = 0.0012, respectively. miRs remained unchanged in SG. miR-126 was similar in all groups. There was a positive association between changes in logmiR-222 and logcECs after metformin in TG (p < 0.05). Anti-angiogenic miRs are increased in T1DM. Metformin has cardioprotective effects through downregulating miR-222, miR-195 and miR-21a, beyond improving glycemic control." @default.
- W2897361250 created "2018-10-26" @default.
- W2897361250 creator A5002949201 @default.
- W2897361250 creator A5003960456 @default.
- W2897361250 creator A5033861335 @default.
- W2897361250 creator A5050598914 @default.
- W2897361250 creator A5085217548 @default.
- W2897361250 date "2018-10-19" @default.
- W2897361250 modified "2023-09-30" @default.
- W2897361250 title "Anti-Angiogenic miR-222, miR-195, and miR-21a Plasma Levels in T1DM Are Improved by Metformin Therapy, Thus Elucidating Its Cardioprotective Effect: The MERIT Study" @default.
- W2897361250 cites W121078932 @default.
- W2897361250 cites W1482811734 @default.
- W2897361250 cites W1588051322 @default.
- W2897361250 cites W1609044025 @default.
- W2897361250 cites W1775937474 @default.
- W2897361250 cites W1800547622 @default.
- W2897361250 cites W1829751033 @default.
- W2897361250 cites W1867504242 @default.
- W2897361250 cites W1898024728 @default.
- W2897361250 cites W1963753909 @default.
- W2897361250 cites W1965748339 @default.
- W2897361250 cites W1968102833 @default.
- W2897361250 cites W1968904691 @default.
- W2897361250 cites W1969218281 @default.
- W2897361250 cites W1971441087 @default.
- W2897361250 cites W1975057002 @default.
- W2897361250 cites W1987417961 @default.
- W2897361250 cites W1987852564 @default.
- W2897361250 cites W1988012375 @default.
- W2897361250 cites W1988964743 @default.
- W2897361250 cites W1991886835 @default.
- W2897361250 cites W1994494031 @default.
- W2897361250 cites W1995315402 @default.
- W2897361250 cites W2000851646 @default.
- W2897361250 cites W2008062764 @default.
- W2897361250 cites W2009323346 @default.
- W2897361250 cites W2015595562 @default.
- W2897361250 cites W2030497421 @default.
- W2897361250 cites W2051477541 @default.
- W2897361250 cites W2057599529 @default.
- W2897361250 cites W2060374902 @default.
- W2897361250 cites W2077236610 @default.
- W2897361250 cites W2087206434 @default.
- W2897361250 cites W2090761865 @default.
- W2897361250 cites W2093070110 @default.
- W2897361250 cites W2096166765 @default.
- W2897361250 cites W2096367638 @default.
- W2897361250 cites W2097668381 @default.
- W2897361250 cites W2097837136 @default.
- W2897361250 cites W2098877258 @default.
- W2897361250 cites W2101001512 @default.
- W2897361250 cites W2105665055 @default.
- W2897361250 cites W2106072567 @default.
- W2897361250 cites W2113506865 @default.
- W2897361250 cites W2115093090 @default.
- W2897361250 cites W2117781794 @default.
- W2897361250 cites W2127131367 @default.
- W2897361250 cites W2132892030 @default.
- W2897361250 cites W2136154089 @default.
- W2897361250 cites W2138814576 @default.
- W2897361250 cites W2140091575 @default.
- W2897361250 cites W2140151300 @default.
- W2897361250 cites W2146668212 @default.
- W2897361250 cites W2153045641 @default.
- W2897361250 cites W2156472431 @default.
- W2897361250 cites W2161068194 @default.
- W2897361250 cites W2162137461 @default.
- W2897361250 cites W2168420558 @default.
- W2897361250 cites W2188846692 @default.
- W2897361250 cites W2271771390 @default.
- W2897361250 cites W2277130803 @default.
- W2897361250 cites W2301467648 @default.
- W2897361250 cites W2463628819 @default.
- W2897361250 cites W2508361252 @default.
- W2897361250 cites W2517901119 @default.
- W2897361250 cites W2548381372 @default.
- W2897361250 cites W2624031057 @default.
- W2897361250 cites W2699220065 @default.
- W2897361250 cites W2746457139 @default.
- W2897361250 cites W2787621552 @default.
- W2897361250 cites W330316361 @default.
- W2897361250 doi "https://doi.org/10.3390/ijms19103242" @default.
- W2897361250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6214022" @default.
- W2897361250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347712" @default.
- W2897361250 hasPublicationYear "2018" @default.
- W2897361250 type Work @default.
- W2897361250 sameAs 2897361250 @default.
- W2897361250 citedByCount "20" @default.
- W2897361250 countsByYear W28973612502018 @default.
- W2897361250 countsByYear W28973612502019 @default.
- W2897361250 countsByYear W28973612502021 @default.
- W2897361250 countsByYear W28973612502022 @default.
- W2897361250 countsByYear W28973612502023 @default.
- W2897361250 crossrefType "journal-article" @default.
- W2897361250 hasAuthorship W2897361250A5002949201 @default.
- W2897361250 hasAuthorship W2897361250A5003960456 @default.
- W2897361250 hasAuthorship W2897361250A5033861335 @default.
- W2897361250 hasAuthorship W2897361250A5050598914 @default.