FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897364508> ?p ?o ?g. }

• W2897364508 endingPage "e575" @default.
• W2897364508 startingPage "e574" @default.
• W2897364508 abstract "To investigate the patterns and prognostic factors of locoregional recurrence(LRR) in patients with N2-3a breast cancer after post-mastectomy radiation(PMRT). Women with breast cancer with pathologically confirmed at least 4 axillary lymph nodes metastasis treated with PMRT were extracted from our established database, which including all the breast cancer cases treated at our institution from 1999/1 to 2013/12. Patients with initially distant, internal mammary(IM) or supraclavicular(SC) lymph nodes metastasis, as well as those treated with neoadjuvant chemotherapy were excluded. We estimated survival curves using the Kaplan–Meier method, and used the log-rank test and Cox regression to determine the prognostic factors. A total of 1623 patients were included, with the median age of 48 years. The median breast tumor size was 2.5 cm. The median number of axillary positive lymph nodes was 8. ER/PR positive were seen in 75.5% of patients, Her-2 positive in 22.9% of patients, while only 9.7% patients were triple negative. All patients received radiation to the chest wall(CW) and SC. Axillary was irradiated in 200 (12.3%) patients, while only 6.7%(109) of patients underwent IM radiation. Nearly all patients received adjuvant chemotherapy. In HER-2 positive group, only 32.6%(121/371) patients received anti-HER2 therapy. While 83.3% (1021) of patients had endocrine therapy if needed. After a median follow up of 5.14 year, 26.7%(433) patients had a relapse, including 108 cases of LRR and 433 of distant metastasis. The 5-year overall survival, disease free survival and LRR free survival was 95.9%(95%CI 94.9-97.0%), 72.6%(95%CI 72.4-77.1%) and 93.6%(95%CI 92.3-95.0%), respectively. In LRR patients, 34(31.5%) cases were in the CW, 36(33.3%) in the axillary fossa, 60(55.6%) in the SC, while only 8(7.4%) cases in the IM. The 5-year recurrence rate was 1.9% in CW, 2.1% in axillary fossa, 3.6% in SC, and only 0.4% in IM. Age, tumor size, positive axillary lymph nodes(AXLN) number and molecular subtype were independent risk factors for LRR. Tumor size, vessel invasion and positive AXLN percentage were risk factors for CW recurrence. The 5-year CW recurrence rate was 0.9% in patients with 0-1 risk factors compared to 4.6% in those with 2-3 risk factors(p=0.000). For axillary recurrence, tumor size, the positive AXLN number and HER-2 status were prognostic factors. The 5-year axillary recurrence rate differs in risk groups (low: 1.8% vs. high: 7.8%, p = 0.000). ER/PR status, age and positive AXLN number were prognostic factors for SC recurrence. The 5-year SC recurrence rate were also different (low: 3.2% vs. high: 9.4%, p = 0.000). The LRR rate was quite low in N2-3 breast cancer after PMRT. The risk groups for specific sites at risk may help clinicians to recognize the high risk patients and modify the locoregional treatment individually." @default.
• W2897364508 created "2018-10-26" @default.
• W2897364508 creator A5015924742 @default.
• W2897364508 creator A5019705219 @default.
• W2897364508 creator A5027861145 @default.
• W2897364508 creator A5028232848 @default.
• W2897364508 creator A5028809442 @default.
• W2897364508 creator A5035945871 @default.
• W2897364508 creator A5039643518 @default.
• W2897364508 creator A5042770421 @default.
• W2897364508 creator A5047488872 @default.
• W2897364508 creator A5052838274 @default.
• W2897364508 creator A5066610865 @default.
• W2897364508 creator A5067568342 @default.
• W2897364508 creator A5079569446 @default.
• W2897364508 creator A5081419934 @default.
• W2897364508 date "2018-11-01" @default.
• W2897364508 modified "2023-09-27" @default.
• W2897364508 title "Risk Factors of Locoregional Recurrence in Patients with N2-3a Breast Cancer Treated with Post Mastectomy Radiation" @default.
• W2897364508 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1590" @default.
• W2897364508 hasPublicationYear "2018" @default.
• W2897364508 type Work @default.
• W2897364508 sameAs 2897364508 @default.
• W2897364508 citedByCount "0" @default.
• W2897364508 crossrefType "journal-article" @default.
• W2897364508 hasAuthorship W2897364508A5015924742 @default.
• W2897364508 hasAuthorship W2897364508A5019705219 @default.
• W2897364508 hasAuthorship W2897364508A5027861145 @default.
• W2897364508 hasAuthorship W2897364508A5028232848 @default.
• W2897364508 hasAuthorship W2897364508A5028809442 @default.
• W2897364508 hasAuthorship W2897364508A5035945871 @default.
• W2897364508 hasAuthorship W2897364508A5039643518 @default.
• W2897364508 hasAuthorship W2897364508A5042770421 @default.
• W2897364508 hasAuthorship W2897364508A5047488872 @default.
• W2897364508 hasAuthorship W2897364508A5052838274 @default.
• W2897364508 hasAuthorship W2897364508A5066610865 @default.
• W2897364508 hasAuthorship W2897364508A5067568342 @default.
• W2897364508 hasAuthorship W2897364508A5079569446 @default.
• W2897364508 hasAuthorship W2897364508A5081419934 @default.
• W2897364508 hasBestOaLocation W28973645081 @default.
• W2897364508 hasConcept C121608353 @default.
• W2897364508 hasConcept C126322002 @default.
• W2897364508 hasConcept C141071460 @default.
• W2897364508 hasConcept C142724271 @default.
• W2897364508 hasConcept C143998085 @default.
• W2897364508 hasConcept C2776608951 @default.
• W2897364508 hasConcept C2776694085 @default.
• W2897364508 hasConcept C2777649267 @default.
• W2897364508 hasConcept C2777757722 @default.
• W2897364508 hasConcept C2779013556 @default.
• W2897364508 hasConcept C2779223589 @default.
• W2897364508 hasConcept C2779720271 @default.
• W2897364508 hasConcept C50382708 @default.
• W2897364508 hasConcept C509974204 @default.
• W2897364508 hasConcept C530470458 @default.
• W2897364508 hasConcept C71924100 @default.
• W2897364508 hasConceptScore W2897364508C121608353 @default.
• W2897364508 hasConceptScore W2897364508C126322002 @default.
• W2897364508 hasConceptScore W2897364508C141071460 @default.
• W2897364508 hasConceptScore W2897364508C142724271 @default.
• W2897364508 hasConceptScore W2897364508C143998085 @default.
• W2897364508 hasConceptScore W2897364508C2776608951 @default.
• W2897364508 hasConceptScore W2897364508C2776694085 @default.
• W2897364508 hasConceptScore W2897364508C2777649267 @default.
• W2897364508 hasConceptScore W2897364508C2777757722 @default.
• W2897364508 hasConceptScore W2897364508C2779013556 @default.
• W2897364508 hasConceptScore W2897364508C2779223589 @default.
• W2897364508 hasConceptScore W2897364508C2779720271 @default.
• W2897364508 hasConceptScore W2897364508C50382708 @default.
• W2897364508 hasConceptScore W2897364508C509974204 @default.
• W2897364508 hasConceptScore W2897364508C530470458 @default.
• W2897364508 hasConceptScore W2897364508C71924100 @default.
• W2897364508 hasIssue "3" @default.
• W2897364508 hasLocation W28973645081 @default.
• W2897364508 hasOpenAccess W2897364508 @default.
• W2897364508 hasPrimaryLocation W28973645081 @default.
• W2897364508 hasRelatedWork W1970677298 @default.
• W2897364508 hasRelatedWork W2073937368 @default.
• W2897364508 hasRelatedWork W2103178795 @default.
• W2897364508 hasRelatedWork W2161568138 @default.
• W2897364508 hasRelatedWork W2251976536 @default.
• W2897364508 hasRelatedWork W2352056222 @default.
• W2897364508 hasRelatedWork W2433983651 @default.
• W2897364508 hasRelatedWork W2434776624 @default.
• W2897364508 hasRelatedWork W2759031936 @default.
• W2897364508 hasRelatedWork W3198467966 @default.
• W2897364508 hasVolume "102" @default.
• W2897364508 isParatext "false" @default.
• W2897364508 isRetracted "false" @default.
• W2897364508 magId "2897364508" @default.
• W2897364508 workType "article" @default.