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- W2897374554 abstract "Neurodevelopmental (ND) outcomes have not been reported in infants with LUTO. Texas Children's prenatal classification of LUTO severity correlates well with the degree of fetal renal damage. Our aim was to determine ND outcomes for children with congenital LUTO based on disease severity. Twenty male infants with LUTO were classified based on their prenatal follow up as Stage 1 (normal amniotic fluid and renal function; N=5), Stage 2 (signs of obstruction with preserved renal function; N=13) and Stage 3 (signs of severe renal damage; N=2).12 cases with Stage 2 underwent vesicoamniotic shunt placement. Neurodevelopmental status was determined using the Developmental Profile-3 test. Standard scores in 5 developmental domains (physical, adaptive behaviour, social-emotional, cognitive, and communication) were interpreted as delayed if >2SD below the mean. Odds ratios were calculated to predict risk for adverse ND outcome. 15 of the 20 patients (75%) did not evidence a delay in any domain. Of the 5 patients with a delay, 4 received dialysis and 3 had delays in 1 or more domains. When ND outcomes were compared between stages, no differences were detected except for worse adaptive scores in Stage 3 compared to Stage 2. Patients on dialysis were 15 times more likely to have social-emotional delays (p=0.06). Infants with abnormal renal function had 19 times increased risk for physical delays (p=0.03). Diagnosis of fetal renal failure increased the risk by 30 times to adaptive delays (p=0.03). Most patients with LUTO are not exhibiting ND delays. Our results support the importance of ND monitoring for patients with severe LUTO. Increase severity of LUTO may be associated with poorer ND outcomes. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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- W2897374554 date "2018-10-01" @default.
- W2897374554 modified "2023-09-24" @default.
- W2897374554 title "OP11.10: Neurodevelopmental outcomes in children with congenital lower urinary tract obstruction (LUTO)" @default.
- W2897374554 doi "https://doi.org/10.1002/uog.19491" @default.
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