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• W2897379694 abstract "In addition to the conventional release of free, individual virions, virus dispersal can involve multi-virion assemblies that collectively infect cells. However, the implications of collective infection for viral fitness remain largely unexplored. Using vesicular stomatitis virus, here, we compare the fitness of free versus saliva-aggregated viral particles. We find that aggregation has a positive effect on early progeny production, conferring a fitness advantage relative to equal numbers of free particles in most cell types. The advantage of aggregation resides, at least partially, in increasing the cellular multiplicity of infection. In mouse embryonic fibroblasts, the per capita, short-term viral progeny production peaked for a dose of ca. three infectious particles per cell. This reveals an Allee effect restricting early viral proliferation at the cellular level, which should select for dispersal in groups. We find that genetic complementation between deleterious mutants is probably not the mechanism underlying the fitness advantage of collective infection. Instead, this advantage is cell type dependent and correlates with cellular permissivity to the virus, as well as with the ability of host cells to mount an antiviral innate immune response." @default.
• W2897379694 created "2018-10-26" @default.
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• W2897379694 date "2018-10-01" @default.
• W2897379694 modified "2023-10-15" @default.
• W2897379694 title "Collective Infection of Cells by Viral Aggregates Promotes Early Viral Proliferation and Reveals a Cellular-Level Allee Effect" @default.
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• W2897379694 doi "https://doi.org/10.1016/j.cub.2018.08.028" @default.
• W2897379694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6783297" @default.
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