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- W2897382512 abstract "Free radicals have emerged as new-type and promising candidates for hypoxic tumor treatment, and further study of their therapeutic mechanism by real-time imaging is of great importance to explore their biomedical applications. Herein, we present a smart free-radical generator AuNC-V057-TPP for hypoxic tumor therapy; the AuNC-V057-TPP not only exhibits good therapeutic effect under both hypoxic and normoxic conditions but also can monitor the release of free radicals in real-time both in vitro and in vivo. What is more, with the mitochondria-targeting ability, the AuNC-V057-TPP is demonstrated with improved antitumor efficacy through enhanced free radical level in mitochondria, which leads to mitochondrial membrane damage and ATP production reduction and finally induces cancer cell apoptosis." @default.
- W2897382512 created "2018-10-26" @default.
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- W2897382512 date "2018-10-16" @default.
- W2897382512 modified "2023-10-16" @default.
- W2897382512 title "Real-Time Imaging of Free Radicals for Mitochondria-Targeting Hypoxic Tumor Therapy" @default.
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- W2897382512 doi "https://doi.org/10.1021/acs.nanolett.8b02670" @default.
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