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- W2897388032 abstract "Abstract Helicobacter (H . ) pylori is an important risk factor for gastric malignancies worldwide. Its outer membrane proteome takes an important role in colonization of the human gastric mucosa. However, in zoonotic non- H . pylori helicobacters (NHPHs) also associated with human gastric disease, the composition of the outer membrane (OM) proteome and its relative contribution to disease remain largely unknown. By means of a comprehensive survey of the diversity and distribution of predicted outer membrane proteins (OMPs) identified in all known gastric Helicobacter species with fully annotated genome sequences, we found genus- and species-specific families known or thought to be implicated in virulence. Hop adhesins, part of the Helicobacter -specific family 13 ( Hop , Hor and Hom ) were restricted to the gastric species H . pylori , H . cetorum and H . acinonychis . Hof proteins (family 33) were putative adhesins with predicted Occ- or MOMP-family like 18-stranded β-barrels. They were found to be widespread amongst all gastric Helicobacter species only sporadically detected in enterohepatic Helicobacter species. These latter are other members within the genus Helicobacter , although ecologically and genetically distinct. LpxR, a lipopolysaccharide remodeling factor, was also detected in all gastric Helicobacter species but lacking as well from the enterohepatic species H . cinaedi , H . equorum and H . hepaticus . In conclusion, our systemic survey of Helicobacter OMPs points to species and infection-site specific members that are interesting candidates for future virulence and colonization studies." @default.
- W2897388032 created "2018-10-26" @default.
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- W2897388032 date "2018-10-18" @default.
- W2897388032 modified "2023-10-18" @default.
- W2897388032 title "In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species" @default.
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- W2897388032 doi "https://doi.org/10.1038/s41598-018-32476-1" @default.
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- W2897388032 hasPublicationYear "2018" @default.
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