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- W2897391056 abstract "Copyright information: Taken from Multistep tumorigenesis and the microenvironmentBreast Cancer Research 2004;6(2):93-101.Published online 12 Feb 2004PMCID:PMC400664.Copyright © 2004 BioMed Central Ltd Diagram of normal mammary epithelial cell with extensive cell–cell junctional complexes, apical–basal polarity, and apical secretion. Diagram of mesenchymal-like cell with lack of cell–cell junctions and front to back polarity typical of a motile cell. Immortalized but non-tumorigenic MCF12A cells form a duct-like structure in three-dimensional culture with polarized cells that have extensive cell–cell interactions – attributes of normal mammary epithelial cells , ×400. MCF12A cells transfected with oncogenic Ras show characteristics of metastatic cells in three-dimensional culture, with loss of cell–cell interactions and gain of front–back polarity, which are hallmarks of the mesenchymal cell, ×400. BM, basement membrane; GJ, gap junction; JC, junctional complex; ME, myoepithelial cell; MFG, mammary fat globule." @default.
- W2897391056 created "2018-10-26" @default.
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- W2897391056 date "2011-01-01" @default.
- W2897391056 modified "2023-09-23" @default.
- W2897391056 title "Human mammary epithelial MCF12A cells stably transfected with oncogenic V12Ras exhibit a functional epithelial-to-mesenchymal transition, which is consistent with a metastatic phenotype" @default.
- W2897391056 doi "https://doi.org/10.6084/m9.figshare.31307" @default.
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