FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897397105> ?p ?o ?g. }

• W2897397105 endingPage "e359" @default.
• W2897397105 startingPage "e359" @default.
• W2897397105 abstract "To characterize the outcomes associated with fractionated proton or photon therapy for the treatment of meningiomas. We reviewed the records of 136 patients treated with RT at our institution between 2000 and 2014. Seventy-five (55%) patients received IMRT and 61 (45%) received PBT. The median age of patients was 54 years (57 years IMRT vs. 49 years PBT, P=0.003), while the majority were female (66%) and White (71%). Eighty seven (64%) had base of skull involvement with no differences between PBT and IMRT (P=0.29). Initial treatment for the majority of patients was surgical resection (n=93, 68%) with about half receiving postop RT (45%). Forty three (32%) patients received definitive RT without resection and 51 patients (38%) were treated at the time of recurrence to gross disease. RT was delivered to a median tumor size of 3.0 cm (range, 0.7-11.6) for patients with measurable disease. The median dose was 50.4 GyRBE in 28 fractions. Median follow-up time was 67 mon (range, 0-190; IMRT 91 mon vs. 54 mon, P<0.001) with a 5y OS of 79%. Sixteen (12%) patients developed a LF at a median time of 35 mon (range, 1-63), of which 10 (63%) were in-field, 3 (19%) marginal, and 3 (19%) out-of-field. There was no difference in the actuarial LF rate between PBT and IMRT when stratified by tumor grade (Grade 1: 5y LF 4% [PBT] vs. 6% [IMRT], P=0.35; Grade 2: 5y LF 43% [PBT] vs. 42% [IMRT], P=0.55; Grade 3: 3y LF 0% [PBT] vs. 25% [IMRT], P=0.48), or the median time to recurrence (31 mon [PBT] vs. 48 mon [IMRT], P=0.23) between modalities. As is apparent based on actuarial LF rates, grade 2 (n=11, 52%) and grade 3 (n=1, 13%) had a higher incidence of LF than grade 1 tumors (n=4, 4%; P<0.001). Interestingly, no patients that received definitive RT in the absence of resection (either biopsy only or no tissue acquired) recurred locally, compared with 10 patients receiving postop RT and 6 receiving RT for a gross recurrence (P<0.001). RT modality was not significantly associated with LF on multivariate analysis; the only factors associated with a higher LF rate on multivariate analysis included: grade 2 (HR 14, P<0.001, 95% CI 3.7-49.8) and grade 3 tumors (HR 184.0, P<0.001, 95% CI 11.8-2864.1), as well as larger tumor size (continuous variable, HR 1.43, P=0.003, 95% CI 1.13-1.82). Thirty seven (27%) patients had at least one late toxicity, the majority of which were grade 1-2 (n=24, 65%); there were no grade 5 toxicities. There was no difference between PBT and IMRT in the incidence of grade 1-2 late toxicities (68% vs. 58%) versus higher grade toxicities (32% vs. 42%, P=0.72). Our study demonstrates equivalency in local control for patients receiving PBT compared to IMRT with no significant difference in higher grade toxicities. Furthermore, no patients receiving definitive RT (either biopsy proven grade I or un-biopsied tumors) developed local recurrence." @default.
• W2897397105 created "2018-10-26" @default.
• W2897397105 creator A5004620963 @default.
• W2897397105 creator A5017360357 @default.
• W2897397105 creator A5037655018 @default.
• W2897397105 creator A5037851639 @default.
• W2897397105 creator A5054809773 @default.
• W2897397105 creator A5060593662 @default.
• W2897397105 creator A5061333234 @default.
• W2897397105 creator A5067556895 @default.
• W2897397105 creator A5071173748 @default.
• W2897397105 creator A5072907410 @default.
• W2897397105 creator A5081212023 @default.
• W2897397105 creator A5088198448 @default.
• W2897397105 creator A5090115592 @default.
• W2897397105 date "2018-11-01" @default.
• W2897397105 modified "2023-10-17" @default.
• W2897397105 title "Similar Local Control Rates for Patients with Meningiomas Treated with Proton Therapy vs. IMRT" @default.
• W2897397105 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1082" @default.
• W2897397105 hasPublicationYear "2018" @default.
• W2897397105 type Work @default.
• W2897397105 sameAs 2897397105 @default.
• W2897397105 citedByCount "0" @default.
• W2897397105 crossrefType "journal-article" @default.
• W2897397105 hasAuthorship W2897397105A5004620963 @default.
• W2897397105 hasAuthorship W2897397105A5017360357 @default.
• W2897397105 hasAuthorship W2897397105A5037655018 @default.
• W2897397105 hasAuthorship W2897397105A5037851639 @default.
• W2897397105 hasAuthorship W2897397105A5054809773 @default.
• W2897397105 hasAuthorship W2897397105A5060593662 @default.
• W2897397105 hasAuthorship W2897397105A5061333234 @default.
• W2897397105 hasAuthorship W2897397105A5067556895 @default.
• W2897397105 hasAuthorship W2897397105A5071173748 @default.
• W2897397105 hasAuthorship W2897397105A5072907410 @default.
• W2897397105 hasAuthorship W2897397105A5081212023 @default.
• W2897397105 hasAuthorship W2897397105A5088198448 @default.
• W2897397105 hasAuthorship W2897397105A5090115592 @default.
• W2897397105 hasConcept C141071460 @default.
• W2897397105 hasConcept C159047783 @default.
• W2897397105 hasConcept C2779244869 @default.
• W2897397105 hasConcept C2987315675 @default.
• W2897397105 hasConcept C2989005 @default.
• W2897397105 hasConcept C509974204 @default.
• W2897397105 hasConcept C71924100 @default.
• W2897397105 hasConceptScore W2897397105C141071460 @default.
• W2897397105 hasConceptScore W2897397105C159047783 @default.
• W2897397105 hasConceptScore W2897397105C2779244869 @default.
• W2897397105 hasConceptScore W2897397105C2987315675 @default.
• W2897397105 hasConceptScore W2897397105C2989005 @default.
• W2897397105 hasConceptScore W2897397105C509974204 @default.
• W2897397105 hasConceptScore W2897397105C71924100 @default.
• W2897397105 hasIssue "3" @default.
• W2897397105 hasLocation W28973971051 @default.
• W2897397105 hasOpenAccess W2897397105 @default.
• W2897397105 hasPrimaryLocation W28973971051 @default.
• W2897397105 hasRelatedWork W2005882420 @default.
• W2897397105 hasRelatedWork W2042400800 @default.
• W2897397105 hasRelatedWork W2047967234 @default.
• W2897397105 hasRelatedWork W2117878254 @default.
• W2897397105 hasRelatedWork W2477137756 @default.
• W2897397105 hasRelatedWork W2559422669 @default.
• W2897397105 hasRelatedWork W2978475839 @default.
• W2897397105 hasRelatedWork W30869299 @default.
• W2897397105 hasRelatedWork W83990173 @default.
• W2897397105 hasRelatedWork W935391112 @default.
• W2897397105 hasVolume "102" @default.
• W2897397105 isParatext "false" @default.
• W2897397105 isRetracted "false" @default.
• W2897397105 magId "2897397105" @default.
• W2897397105 workType "article" @default.