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- W2897399209 abstract "We compared maximal plasma concentrations ( C max ) of sildenafil and metabolite n -desmethyl sildenafil in 12 inpatients with left ventricular assist devices (LVADs) on sildenafil (60 mg/day) to the reference range. Sildenafil C max (156.8 ± 124.5 ng/ml) was elevated in 66% of patients, with a two to fivefold increase over the upper limit of the reference range in 25% of patients. Metabolite C max (133.3 ± 102.0 ng/ml) was elevated in 75% of patients, with a three to sevenfold increase over the upper limit of the reference range in 40% of patients. Patients with heart failure and LVADs are at increased risk of concentrated-related sildenafil adverse events." @default.
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- W2897399209 date "2019-07-01" @default.
- W2897399209 modified "2023-09-26" @default.
- W2897399209 title "Pharmacokinetics of Sildenafil in Patients with a Left Ventricular Assist Device: A Word of Caution" @default.
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- W2897399209 doi "https://doi.org/10.1097/mat.0000000000000886" @default.
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