Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897400705> ?p ?o ?g. }
- W2897400705 abstract "Abstract In the Caenorhabditis elegans zygote, PAR protein patterns, driven by mutual anatagonism, determine the anterior-posterior axis and facilitate the redistribution of proteins for the first cell division. Yet, the factors that determine the selection of the polarity axis remain unclear. We present a reaction-diffusion model in realistic cell geometry, based on biomolecular reactions and accounting for the coupling between membrane and cytosolic dynamics. We find that the kinetics of the phosphorylation-dephosphorylation cycle of PARs and the diffusive protein fluxes from the cytosol towards the membrane are crucial for the robust selection of the anterior-posterior axis for polarisation. The local ratio of membrane surface to cytosolic volume is the main geometric cue that initiates pattern formation, while the choice of the long-axis for polarisation is largely determined by the length of the aPAR-pPAR interface, and mediated by processes that minimise the diffusive fluxes of PAR proteins between cytosol and membrane." @default.
- W2897400705 created "2018-10-26" @default.
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- W2897400705 date "2018-10-25" @default.
- W2897400705 modified "2023-09-24" @default.
- W2897400705 title "Geometric cues stabilise long-axis polarisation of PAR protein patterns in C. elegans" @default.
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- W2897400705 doi "https://doi.org/10.1101/451880" @default.
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