Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897404913> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2897404913 endingPage "313" @default.
- W2897404913 startingPage "307" @default.
- W2897404913 abstract "Abstract Introduction Previous knowledge of molecular mechanisms related with multi-drug resistances in tuberculosis is important if molecular diagnostic procedures want to be used in specific geographical regions. For that reason, the aim of this study was to investigate the mutations at rpoB, katG and inhA in multi-drug resistant tuberculosis isolates from Southeast Mexico. Methods Isolates of tuberculosis with a confirmed resistance against rifampicin and isoniazid were collected and sequencing analysis was performed of the rpoB rifampicin resistance-determining region, the katG and the encoding region of inhA. Result Of 74 isolates with multidrug resistance, 34 (46%) presented six mutations in katG; the most abundant was katG315 in 29 (39%) isolates. At inhA, nine (11%) isolates presented three mutations; the most frequent was inhA21, located in five (6%) strains. Eleven polymorphisms were observed at rpoB in 61 (82%) isolates, prevailing rpoB531 and rpoB 526 in 48 (64%) and ten (12%) isolates, respectively. Eleven double combinations were observed in 39 (52%) isolates, the most common of which was rpoB531+katG315, found in 22 (29%) strains. Conclusion This study provides valuable information on the diversity of polymorphisms in genes related to multidrug-resistant tuberculosis, as well as the presence of new mutations not previously described; this information should be considered in the implementation of molecular diagnostic tests." @default.
- W2897404913 created "2018-10-26" @default.
- W2897404913 creator A5066248377 @default.
- W2897404913 creator A5075418481 @default.
- W2897404913 creator A5079857945 @default.
- W2897404913 date "2019-05-01" @default.
- W2897404913 modified "2023-09-24" @default.
- W2897404913 title "rpoB, katG and inhA mutations in multi-drug resistant strains of Mycobacterium tuberculosis clinical isolates from southeast Mexico" @default.
- W2897404913 cites W1520577353 @default.
- W2897404913 cites W1837184534 @default.
- W2897404913 cites W1879094584 @default.
- W2897404913 cites W1966323536 @default.
- W2897404913 cites W2011430907 @default.
- W2897404913 cites W2024826544 @default.
- W2897404913 cites W2050606451 @default.
- W2897404913 cites W2056981303 @default.
- W2897404913 cites W2058745843 @default.
- W2897404913 cites W2073603709 @default.
- W2897404913 cites W2077420910 @default.
- W2897404913 cites W2096402966 @default.
- W2897404913 cites W2096962483 @default.
- W2897404913 cites W2104818573 @default.
- W2897404913 cites W2117777873 @default.
- W2897404913 cites W2125192063 @default.
- W2897404913 cites W2142153057 @default.
- W2897404913 cites W2148656381 @default.
- W2897404913 cites W2150364101 @default.
- W2897404913 cites W2151708720 @default.
- W2897404913 cites W2159266386 @default.
- W2897404913 cites W2167793539 @default.
- W2897404913 cites W2190819969 @default.
- W2897404913 cites W2277656229 @default.
- W2897404913 cites W2327367972 @default.
- W2897404913 cites W2472021049 @default.
- W2897404913 cites W2580367224 @default.
- W2897404913 cites W2791136872 @default.
- W2897404913 cites W4293586679 @default.
- W2897404913 cites W597295739 @default.
- W2897404913 doi "https://doi.org/10.1016/j.eimc.2018.09.002" @default.
- W2897404913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30316618" @default.
- W2897404913 hasPublicationYear "2019" @default.
- W2897404913 type Work @default.
- W2897404913 sameAs 2897404913 @default.
- W2897404913 citedByCount "3" @default.
- W2897404913 countsByYear W28974049132020 @default.
- W2897404913 countsByYear W28974049132022 @default.
- W2897404913 crossrefType "journal-article" @default.
- W2897404913 hasAuthorship W2897404913A5066248377 @default.
- W2897404913 hasAuthorship W2897404913A5075418481 @default.
- W2897404913 hasAuthorship W2897404913A5079857945 @default.
- W2897404913 hasConcept C114851261 @default.
- W2897404913 hasConcept C142724271 @default.
- W2897404913 hasConcept C159047783 @default.
- W2897404913 hasConcept C2776967927 @default.
- W2897404913 hasConcept C2777975735 @default.
- W2897404913 hasConcept C2778340795 @default.
- W2897404913 hasConcept C2780687663 @default.
- W2897404913 hasConcept C2781069245 @default.
- W2897404913 hasConcept C71924100 @default.
- W2897404913 hasConcept C86803240 @default.
- W2897404913 hasConcept C89423630 @default.
- W2897404913 hasConceptScore W2897404913C114851261 @default.
- W2897404913 hasConceptScore W2897404913C142724271 @default.
- W2897404913 hasConceptScore W2897404913C159047783 @default.
- W2897404913 hasConceptScore W2897404913C2776967927 @default.
- W2897404913 hasConceptScore W2897404913C2777975735 @default.
- W2897404913 hasConceptScore W2897404913C2778340795 @default.
- W2897404913 hasConceptScore W2897404913C2780687663 @default.
- W2897404913 hasConceptScore W2897404913C2781069245 @default.
- W2897404913 hasConceptScore W2897404913C71924100 @default.
- W2897404913 hasConceptScore W2897404913C86803240 @default.
- W2897404913 hasConceptScore W2897404913C89423630 @default.
- W2897404913 hasIssue "5" @default.
- W2897404913 hasLocation W28974049131 @default.
- W2897404913 hasOpenAccess W2897404913 @default.
- W2897404913 hasPrimaryLocation W28974049131 @default.
- W2897404913 hasRelatedWork W2030832784 @default.
- W2897404913 hasRelatedWork W2107302335 @default.
- W2897404913 hasRelatedWork W2122261512 @default.
- W2897404913 hasRelatedWork W2128220472 @default.
- W2897404913 hasRelatedWork W2319867629 @default.
- W2897404913 hasRelatedWork W2417407127 @default.
- W2897404913 hasRelatedWork W2738269120 @default.
- W2897404913 hasRelatedWork W2806019303 @default.
- W2897404913 hasRelatedWork W2887719056 @default.
- W2897404913 hasRelatedWork W3185052669 @default.
- W2897404913 hasVolume "37" @default.
- W2897404913 isParatext "false" @default.
- W2897404913 isRetracted "false" @default.
- W2897404913 magId "2897404913" @default.
- W2897404913 workType "article" @default.