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- W2897411993 abstract "Based on novel criteria (Khachaturian ZS,2011), The cerebrospinal fluid (CSF) biomarkers will be significant to improve AD, especially atypical AD diagnosis. The most frequently used biomarkers in routine diagnosis are β-amyloid (Aβ), tau and its phosphorylated form (P-tau). Nevertheless, for further differentiating various dementias such as corticobasal degeneration (CBD), frontotemporal lobar degeneration (FTLD) and Creutzfeldt-Jakob disease (CJD), none of above is of plenty efficacy as there are similar pathological changes in those neurodegenerative diseases. But some researches proved that total tau (T-tau)/Aβ is helpful. (Engelbor ghs S.2013; Schoonenboom NS, 2012). Thus, to obtain proper standard methods and T-tau/Aβ cutoff value for Chinese population, we are running a clinical research among the dementias due to AD, non-AD and other non-dementia neuropathologic impairment. Here we report part of our work. We examined CSF Aβ42, T-tau and calculated the T-tau/Aβ ratio in 33 patients including 15 probable and possible AD (NIA-AA 2011 criteria), and 18 non-AD dementia patients including idiopathic normal pressure hydrocephalus (iNPH), FTLD, etc. CSF specimens were taken at 8am and biomarkers were measured by enzyme-linked immunosorbent assay (ELISA). All statistical analyses were performed with IBM SPSS Statistics 22. Our research discovered a remarkable increasing of T-tau/Aβ ratio in AD (p<0.01). Furthermore, we categorized T-tau/Aβ ratio into three stages: high (>1.3), medium (0.3-1.3) and low (<0.3). The AD group had significantly higher T-tau/Aβ in ranking, comparing with non-AD (p<0.001). Only 1 in 15 ADs locates in medium rank. In non-AD group, the false positive cases are believed due to severe destruction of neural tissue, which requires specific p-tau and clinical course to assist. The CSF T-tau/Aβ allows more efficient AD diagnosis and differentiation from various types of dementias. More work is currently undergone to accumulate T-tau/Aβ in larger population to explore a reliable ratio distribution and cutoff value for Chinese population. This work was supported by CAMS Innovation fund for medical sciences (2016-I2M-1-004), National Natural Science Foundation of China (81550021, 30470618), 13th Five year National Key Research and Development Program of China (2016YFC1306300) ." @default.
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- W2897411993 date "2018-07-01" @default.
- W2897411993 modified "2023-10-16" @default.
- W2897411993 title "P1‐253: THE ROLE OF CEREBROSPINAL FLUID T‐TAU/Aβ RATIO IN DIFFERENTIATION OF AD FROM NON‐AD DEMENTIA" @default.
- W2897411993 doi "https://doi.org/10.1016/j.jalz.2018.06.259" @default.
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