FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897413231> ?p ?o ?g. }

• W2897413231 endingPage "95" @default.
• W2897413231 startingPage "86" @default.
• W2897413231 abstract "In healthy adults, successful between-session recall of extinction learning depends on the hippocampus and ventromedial prefrontal cortex (vmPFC), especially when tested in the extinction context. Poor extinction recall and dysfunction within hippocampal-vmPFC circuitry are associated with fear-based disorders (e.g., anxiety, posttraumatic stress disorder). Despite the early age of onset of virtually all fear-based disorders and the protracted development of the hippocampus and vmPFC across the first two decades of life, little is known about extinction recall and the underlying neural correlates in children. Here, we tested extinction recall in 43 pre-adolescent children (ages 6–11 yrs) by coupling functional magnetic resonance imaging and virtual reality with a novel interpersonal threat-related two-day (ABBA) fear-extinction paradigm. Conditioned fear responding was assessed at behavioral, subjective, physiological, and neural levels. Although children demonstrated intact within-session extinction, there was poor between-session recall of extinction learning (retention index: 13.56%), evidenced by elevations in skin conductance, avoidant behavioral responses, and subjective ratings. Elevations in conditioning fear responding were accompanied by activation in the hippocampus and insula, and increased connectivity of the hippocampus with the insula and dorsal anterior cingulate cortex - regions implicated in the return of fear in adult studies. Children who kept more distance from the extinguished cue during extinction subsequently demonstrated heightened hippocampal-cingulate coupling during recall, suggesting that avoidant behavior interferes with extinction retention. Poor extinction recall in children may have implications for developmental vulnerability to fear-based disorders, and for the application of therapeutic strategies that rely on principles of extinction (e.g., exposure therapy) to pediatric samples." @default.
• W2897413231 created "2018-10-26" @default.
• W2897413231 creator A5004834469 @default.
• W2897413231 creator A5007028314 @default.
• W2897413231 creator A5023294840 @default.
• W2897413231 creator A5072173846 @default.
• W2897413231 date "2018-12-01" @default.
• W2897413231 modified "2023-10-17" @default.
• W2897413231 title "Poor between-session recall of extinction learning and hippocampal activation and connectivity in children" @default.
• W2897413231 cites W140219456 @default.
• W2897413231 cites W1580238921 @default.
• W2897413231 cites W1966852679 @default.
• W2897413231 cites W1967296112 @default.
• W2897413231 cites W1969819227 @default.
• W2897413231 cites W1970006557 @default.
• W2897413231 cites W1974143886 @default.
• W2897413231 cites W1975341827 @default.
• W2897413231 cites W1980377882 @default.
• W2897413231 cites W1992402923 @default.
• W2897413231 cites W1992503298 @default.
• W2897413231 cites W1993593676 @default.
• W2897413231 cites W2001620133 @default.
• W2897413231 cites W2003598308 @default.
• W2897413231 cites W2016521818 @default.
• W2897413231 cites W2024045888 @default.
• W2897413231 cites W2025643983 @default.
• W2897413231 cites W2036537456 @default.
• W2897413231 cites W2044892217 @default.
• W2897413231 cites W2046766033 @default.
• W2897413231 cites W2049549817 @default.
• W2897413231 cites W2049812132 @default.
• W2897413231 cites W2051925828 @default.
• W2897413231 cites W2052401494 @default.
• W2897413231 cites W2058046532 @default.
• W2897413231 cites W2060161739 @default.
• W2897413231 cites W2068782491 @default.
• W2897413231 cites W2076791702 @default.
• W2897413231 cites W2076938137 @default.
• W2897413231 cites W2077083873 @default.
• W2897413231 cites W2083336749 @default.
• W2897413231 cites W2084994226 @default.
• W2897413231 cites W2098124330 @default.
• W2897413231 cites W2103791867 @default.
• W2897413231 cites W2110496900 @default.
• W2897413231 cites W2113485684 @default.
• W2897413231 cites W2116658855 @default.
• W2897413231 cites W2118826874 @default.
• W2897413231 cites W2120495407 @default.
• W2897413231 cites W2126897275 @default.
• W2897413231 cites W2127438603 @default.
• W2897413231 cites W2130394290 @default.
• W2897413231 cites W2140201388 @default.
• W2897413231 cites W2143337872 @default.
• W2897413231 cites W2146278257 @default.
• W2897413231 cites W2149193362 @default.
• W2897413231 cites W2152444032 @default.
• W2897413231 cites W2156188967 @default.
• W2897413231 cites W2158150946 @default.
• W2897413231 cites W2159947310 @default.
• W2897413231 cites W2161391198 @default.
• W2897413231 cites W2274586000 @default.
• W2897413231 cites W2286242948 @default.
• W2897413231 cites W2302434353 @default.
• W2897413231 cites W2333576952 @default.
• W2897413231 cites W2518030127 @default.
• W2897413231 cites W2537942565 @default.
• W2897413231 cites W2590359509 @default.
• W2897413231 cites W2592144218 @default.
• W2897413231 cites W2612971138 @default.
• W2897413231 cites W2614040844 @default.
• W2897413231 cites W2769123483 @default.
• W2897413231 cites W2951739059 @default.
• W2897413231 cites W4249894887 @default.
• W2897413231 cites W814793908 @default.
• W2897413231 cites W987539735 @default.
• W2897413231 doi "https://doi.org/10.1016/j.nlm.2018.10.007" @default.
• W2897413231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6286149" @default.
• W2897413231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347237" @default.
• W2897413231 hasPublicationYear "2018" @default.
• W2897413231 type Work @default.
• W2897413231 sameAs 2897413231 @default.
• W2897413231 citedByCount "9" @default.
• W2897413231 countsByYear W28974132312020 @default.
• W2897413231 countsByYear W28974132312021 @default.
• W2897413231 countsByYear W28974132312022 @default.
• W2897413231 countsByYear W28974132312023 @default.
• W2897413231 crossrefType "journal-article" @default.
• W2897413231 hasAuthorship W2897413231A5004834469 @default.
• W2897413231 hasAuthorship W2897413231A5007028314 @default.
• W2897413231 hasAuthorship W2897413231A5023294840 @default.
• W2897413231 hasAuthorship W2897413231A5072173846 @default.
• W2897413231 hasBestOaLocation W28974132311 @default.
• W2897413231 hasConcept C100660578 @default.
• W2897413231 hasConcept C101991246 @default.
• W2897413231 hasConcept C104996578 @default.
• W2897413231 hasConcept C138496976 @default.
• W2897413231 hasConcept C148762608 @default.
• W2897413231 hasConcept C151730666 @default.

• next