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• W2897416230 abstract "Background/Aims: HER2 has been implicated in mammary tumorigenesis as well as aggressive tumor growth and metastasis. Its overexpression is related to a poor prognosis and chemoresistance in breast cancer patients. Although Grb2-associated binding protein 2 (Gab2) is important in the development and progression of human cancer, its effects and mechanisms in HER2-overexpressing breast cancer are unclear. Methods: Clone formation and MTT assays were used to examine cell proliferation. To detect the effect of Gab2 on the stemness of breast cancer cells, we used flow cytometry, a sphere formation assay, real-time PCR, and western blot. An animal model was created to validate the effect of Gab2 on tumor growth in vivo. Tissue slides were analyzed by immunohistochemistry. Results: Knockdown of Gab2 suppressed PI3K/AKT and MAPK/ERK pathway activity. Gab2 ablation also reduced the stemness of HER2-overexpressing breast cancer cells. In vivo, knockdown of Gab2 inhibited tumor growth. Conclusion: This study unveils a potential function of Gab2 in HER2-overexpressing breast cancer cells. Gab2 might be a potential target in the clinical therapy of HER2-overexpressing breast carcinoma." @default.
• W2897416230 created "2018-10-26" @default.
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• W2897416230 date "2018-01-01" @default.
• W2897416230 modified "2023-10-13" @default.
• W2897416230 title "Gab2 Ablation Reverses the Stemness of HER2-Overexpressing Breast Cancer Cells" @default.
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• W2897416230 doi "https://doi.org/10.1159/000493957" @default.
• W2897416230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326469" @default.
• W2897416230 hasPublicationYear "2018" @default.
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