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• W2897417196 abstract "Peptoids are peptidomimetic polymers, which have attracted much attention over the past two decades. They have similar building blocks to peptides, and the similarity makes the backbone of peptoids hydrophilic and biocompatible.1 Two types of peptoid polymers are under development. One is sequence-defined peptoids, which exhibit excellent bioactivities.2 Another one is polypeptoids. The good biocompatibility and highly tunable side chain substituents allow polypeptoids to be used broadly in future biomedical applications. Varying polymer architectures, including linear polymers, cyclic polymers, comb-like polymers, and dendrimers can provide distinctive properties to the polymers. Cyclic polymers employ a cyclic architecture and lack chain ends, so their diffusion behaviors, aggregation behaviors, thermal transition behaviors, and crystallization behaviors are very different from the linear analogs. Facile synthetic approaches are required to expand the application of cyclic polymers into a broader scope. In chapter 1, the history of polypeptoids, the synthesis of cyclic polymers, the development of functional polypeptoids, and the cutting-edge biomedical research of polypeptoids were reviewed. In chapter 2, we reported our most recent work of the polymerization reaction of cyclic polypeptoids using a bicyclic amidine initiator. The study was described from the aspects of molecular weight control, identification of the polymerization, kinetics of the polymerization, and polymer architecture. Zwitterionic ring-opening polymerization of N-substituted N-carboxyanhydrides (R-NCA) mediated by the bicyclic amidine has been developed and well-defined cyclic polypeptoids can be synthesized. Pursuit of varying polymer architectures never ends because unique properties can be possibly discovered with the latest developed architecture. Besides cyclic polymers, linear bottlebrush polymers also attracted much attention due to their distinctive features. In chapter 3, we took one step forward and synthesized the cyclic bottlebrush polypeptoids. We then conducted a systematic study on the characterization of the cyclic bottlebrush polypeptoids and on the solution aggregation behaviors of zwitterionic cyclic polypeptoids with and without long side chains. It was revealed that zwitterionic cyclic polypeptoids tend to form clusters due to dipole-dipole interaction in methanol and even the long side chains cannot prevent this process. Another important direction of polypeptoid research, the biomedical application, was assessed in chapter 4. Redox-responsive micelles based on amphiphilic diblock copolypeptoids were prepared, and the solution stability, the morphology in dry state, the redox-responsive behaviors, drug release in vitro, and cell viability and cell inhibition activity of the micelles were completely studied." @default.
• W2897417196 created "2018-10-26" @default.
• W2897417196 creator A5059605240 @default.
• W2897417196 date "2022-06-10" @default.
• W2897417196 modified "2023-10-15" @default.
• W2897417196 title "Synthesis and Characterization of Cyclic Polypeptoids by Organo-Mediated Controlled Zwitterionic Ring-Opening Polymerization and Development of Redox-Responsive Polypeptoid Micelles as Drug Delivery Carriers" @default.
• W2897417196 cites W1488083143 @default.
• W2897417196 cites W1518314422 @default.
• W2897417196 cites W1563858629 @default.
• W2897417196 cites W1573136382 @default.
• W2897417196 cites W1574338658 @default.
• W2897417196 cites W1821674784 @default.
• W2897417196 cites W1871308790 @default.
• W2897417196 cites W1913419146 @default.
• W2897417196 cites W1927566132 @default.
• W2897417196 cites W1929889616 @default.
• W2897417196 cites W1961686835 @default.
• W2897417196 cites W1964758803 @default.
• W2897417196 cites W1964869187 @default.
• W2897417196 cites W1964963209 @default.
• W2897417196 cites W1966351136 @default.
• W2897417196 cites W1966666923 @default.
• W2897417196 cites W1966692557 @default.
• W2897417196 cites W1971731968 @default.
• W2897417196 cites W1973707642 @default.
• W2897417196 cites W1973815785 @default.
• W2897417196 cites W1974526584 @default.
• W2897417196 cites W1978587419 @default.
• W2897417196 cites W1979849149 @default.
• W2897417196 cites W1982260262 @default.
• W2897417196 cites W1984311746 @default.
• W2897417196 cites W1985435463 @default.
• W2897417196 cites W1985772681 @default.
• W2897417196 cites W1986339830 @default.
• W2897417196 cites W1986573303 @default.
• W2897417196 cites W1986714586 @default.
• W2897417196 cites W1989489362 @default.
• W2897417196 cites W1990163407 @default.
• W2897417196 cites W1994276037 @default.
• W2897417196 cites W1995008606 @default.
• W2897417196 cites W1998949133 @default.
• W2897417196 cites W2000294235 @default.
• W2897417196 cites W2001786338 @default.
• W2897417196 cites W2003124589 @default.
• W2897417196 cites W2003730544 @default.
• W2897417196 cites W2003949305 @default.
• W2897417196 cites W2004853951 @default.
• W2897417196 cites W2004874640 @default.
• W2897417196 cites W2005037150 @default.
• W2897417196 cites W2007063468 @default.
• W2897417196 cites W2008294808 @default.
• W2897417196 cites W2009482748 @default.
• W2897417196 cites W2009692654 @default.
• W2897417196 cites W2010385092 @default.
• W2897417196 cites W2012252132 @default.
• W2897417196 cites W2012893255 @default.
• W2897417196 cites W2013221825 @default.
• W2897417196 cites W2013712870 @default.
• W2897417196 cites W2013722538 @default.
• W2897417196 cites W2014516639 @default.
• W2897417196 cites W2015467604 @default.
• W2897417196 cites W2018902955 @default.
• W2897417196 cites W2020874710 @default.
• W2897417196 cites W2021138079 @default.
• W2897417196 cites W2022315563 @default.
• W2897417196 cites W2022729090 @default.
• W2897417196 cites W2023438921 @default.
• W2897417196 cites W2023634298 @default.
• W2897417196 cites W2027098350 @default.
• W2897417196 cites W2029617337 @default.
• W2897417196 cites W2029829580 @default.
• W2897417196 cites W2030411720 @default.
• W2897417196 cites W2030713462 @default.
• W2897417196 cites W2030841219 @default.
• W2897417196 cites W2032069963 @default.
• W2897417196 cites W2032505506 @default.
• W2897417196 cites W2032860131 @default.
• W2897417196 cites W2036573016 @default.
• W2897417196 cites W2037382830 @default.
• W2897417196 cites W2041189078 @default.
• W2897417196 cites W2042542856 @default.
• W2897417196 cites W2043877517 @default.
• W2897417196 cites W2043929325 @default.
• W2897417196 cites W2045008162 @default.
• W2897417196 cites W2045112665 @default.
• W2897417196 cites W2045642095 @default.
• W2897417196 cites W2046597623 @default.
• W2897417196 cites W2050365704 @default.
• W2897417196 cites W2050498736 @default.
• W2897417196 cites W2050832424 @default.
• W2897417196 cites W2051381895 @default.
• W2897417196 cites W2052209570 @default.
• W2897417196 cites W2052266727 @default.
• W2897417196 cites W2053426009 @default.
• W2897417196 cites W2054609339 @default.
• W2897417196 cites W2057923438 @default.
• W2897417196 cites W2058289726 @default.
• W2897417196 cites W2061613298 @default.
• W2897417196 cites W2061713344 @default.
• W2897417196 cites W2061807324 @default.

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