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• W2897417438 startingPage "30" @default.
• W2897417438 abstract "Vascular remodeling defines cancer growth and aggressiveness. Although cancer cells produce pro-angiogenic signals, the fate of angiogenesis critically depends on the cancer microenvironment. Composition of the extracellular matrix (ECM) and tumor inflammation determine whether a cancer will remain dormant, will be recognized by the immune system and eliminated, or whether the tumor will develop and lead to the spread and metastasis of cancer cells. Thrombospondins (TSPs), a family of ECM proteins that has long been associated with the regulation of angiogenesis and cancer, regulate multiple physiological processes that determine cancer growth and spreading, from angiogenesis to inflammation, metabolic changes, and properties of ECM. Here, we sought to review publications that describe various functions of TSPs that link these proteins to regulation of cancer growth by modulating multiple physiological and pathological events that prevent or support tumor development. In addition to its direct effects on angiogenesis, TSPs have important roles in regulation of inflammation, immunity, ECM properties and composition, and glucose and insulin metabolism. Furthermore, TSPs have distinct roles as regulators of remodeling in tissues and tumors, such that the pathways activated by a single TSP can interact and influence each other. The complex nature of TSP interactions and functions, including their different cell- and tissue-specific effects, may lead to confusing results and controversial conclusions when taken out of the context of interdisciplinary and holistic approaches. However, studies of TSP functions and roles in different systems of the organism offer an integrative view of tumor remodeling and a potential for finding therapeutic targets that would modulate multiple complementary processes associated with cancer growth." @default.
• W2897417438 created "2018-10-26" @default.
• W2897417438 creator A5034339268 @default.
• W2897417438 creator A5062185931 @default.
• W2897417438 creator A5088638614 @default.
• W2897417438 date "2018-10-10" @default.
• W2897417438 modified "2023-09-24" @default.
• W2897417438 title "Thrombospondins and remodeling of the tumor microenvironment" @default.
• W2897417438 cites W1492653638 @default.
• W2897417438 cites W1501495997 @default.
• W2897417438 cites W1505957065 @default.
• W2897417438 cites W1533713644 @default.
• W2897417438 cites W1549631663 @default.
• W2897417438 cites W1551518644 @default.
• W2897417438 cites W1750572319 @default.
• W2897417438 cites W1827311264 @default.
• W2897417438 cites W1838323527 @default.
• W2897417438 cites W1861439258 @default.
• W2897417438 cites W1885001490 @default.
• W2897417438 cites W1912124796 @default.
• W2897417438 cites W1918712426 @default.
• W2897417438 cites W1946162597 @default.
• W2897417438 cites W1954270231 @default.
• W2897417438 cites W1964760330 @default.
• W2897417438 cites W1965037168 @default.
• W2897417438 cites W1967773283 @default.
• W2897417438 cites W1968234252 @default.
• W2897417438 cites W1969980017 @default.
• W2897417438 cites W1972204674 @default.
• W2897417438 cites W1974033843 @default.
• W2897417438 cites W1978545732 @default.
• W2897417438 cites W1980942059 @default.
• W2897417438 cites W1983370580 @default.
• W2897417438 cites W1983956381 @default.
• W2897417438 cites W1988782755 @default.
• W2897417438 cites W1989151475 @default.
• W2897417438 cites W1990748729 @default.
• W2897417438 cites W1993360635 @default.
• W2897417438 cites W1996165027 @default.
• W2897417438 cites W1997035694 @default.
• W2897417438 cites W1997693327 @default.
• W2897417438 cites W2000054651 @default.
• W2897417438 cites W2001252046 @default.
• W2897417438 cites W2001726138 @default.
• W2897417438 cites W2003246509 @default.
• W2897417438 cites W2004128109 @default.
• W2897417438 cites W2004182318 @default.
• W2897417438 cites W2005895632 @default.
• W2897417438 cites W2006628284 @default.
• W2897417438 cites W2007634515 @default.
• W2897417438 cites W2007799501 @default.
• W2897417438 cites W2007970283 @default.
• W2897417438 cites W2009851608 @default.
• W2897417438 cites W2010850700 @default.
• W2897417438 cites W2011319382 @default.
• W2897417438 cites W2011620288 @default.
• W2897417438 cites W2012060788 @default.
• W2897417438 cites W2016252952 @default.
• W2897417438 cites W2016391435 @default.
• W2897417438 cites W2018625409 @default.
• W2897417438 cites W2021857124 @default.
• W2897417438 cites W2021969694 @default.
• W2897417438 cites W2022665089 @default.
• W2897417438 cites W2023659339 @default.
• W2897417438 cites W2024218144 @default.
• W2897417438 cites W2024626734 @default.
• W2897417438 cites W2027084730 @default.
• W2897417438 cites W2028395883 @default.
• W2897417438 cites W2030706156 @default.
• W2897417438 cites W2032220572 @default.
• W2897417438 cites W2032511198 @default.
• W2897417438 cites W2033142105 @default.
• W2897417438 cites W2033278321 @default.
• W2897417438 cites W2033791403 @default.
• W2897417438 cites W2034792933 @default.
• W2897417438 cites W2039802517 @default.
• W2897417438 cites W2040153748 @default.
• W2897417438 cites W2040328047 @default.
• W2897417438 cites W2043236594 @default.
• W2897417438 cites W2043249881 @default.
• W2897417438 cites W2047882452 @default.
• W2897417438 cites W2049172410 @default.
• W2897417438 cites W2051073305 @default.
• W2897417438 cites W2055515174 @default.
• W2897417438 cites W2059322719 @default.
• W2897417438 cites W2062065058 @default.
• W2897417438 cites W2072680312 @default.
• W2897417438 cites W2073026500 @default.
• W2897417438 cites W2077806048 @default.
• W2897417438 cites W2080571923 @default.
• W2897417438 cites W2081471836 @default.
• W2897417438 cites W2083283637 @default.
• W2897417438 cites W2085939705 @default.
• W2897417438 cites W2087749727 @default.
• W2897417438 cites W2088777095 @default.
• W2897417438 cites W2089148552 @default.
• W2897417438 cites W2090747549 @default.
• W2897417438 cites W2093760093 @default.

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