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- W2897427370 abstract "The mammalian fetus and newborn can survive far more prolonged periods of hypoxia-ischaemia without neural injury than adults. In part, this remarkable physiological resilience reflects the effectiveness of its endogenous protective processes that help to suppress injurious events that evolve over time after hypoxia-ischaemia (HI). Many cells are able to recover from even relatively severe periods of HI, in a latent phase marked by adaptive hypometabolism, with reduced brain activity, leading to a high rate of mild body and brain hypothermia, unless it is prevented by external warming. From approximately 4 to 8 h after HI secondary energy failure progressively develops, leading to delayed cell swelling and secondary seizures and ultimately cell death. The latent phase offers the key window for interventions to prevent bulk cell loss, as strongly supported by the successful clinical translation of therapeutic hypothermia. Therapeutic hypothermia is partially protective. Thus, promoting endogenous protective processes may help further improve treatment of acute neonatal encephalopathy." @default.
- W2897427370 created "2018-10-26" @default.
- W2897427370 creator A5002225226 @default.
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- W2897427370 creator A5039019537 @default.
- W2897427370 creator A5047041488 @default.
- W2897427370 creator A5073779145 @default.
- W2897427370 date "2018-10-08" @default.
- W2897427370 modified "2023-09-24" @default.
- W2897427370 title "Endogenous neuroprotection after perinatal hypoxia-ischaemia: the resilient developing brain" @default.
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