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- W2897428465 abstract "Subjective cognitive decline (SCD), a risk factor of Alzheimer's disease, was previously associated with subtle alterations in the hippocampus, a potential target for early intervention. Administration of the natural polyamine spermidine, an autophagy-enhancing agent, can rescue synaptic functionality and thereby prevent memory loss in aging model systems (Gupta, et al., 2013). In a translational Phase-II trial, we first determined favorable compliance, safety, and tolerability profiles of spermidine supplementation in humans (Schwarz, et al., 2018). Here, we evaluated the impact of nutritional spermidine on hippocampus-dependent memory performance in aging adults with SCD. Participants with SCD and self-reported worry (n = 30, 2 drop-outs) were included in the 3-months randomized, placebo-controlled, double-blind intervention trial with a spermidine-rich plant extract. Episodic memory was assessed using a behavioral mnemonic discrimination task, known to involve the hippocampal network, and compared between intervention groups (spermidine and placebo). Memory performance, measured through mnemonic discrimination performance, was enhanced in the spermidine group compared with the placebo-treated group at the end of intervention (Cohen's d = 0.77). Within group comparisons corroborated that this central component of episodic memory improved in the spermidine-treated (Cohen's d = 0.80) and not in the placebo-treated (Cohen's d = 0.20) group. There were no treatment effects on behavioral measures of recognition memory and overall task performance at the end of intervention. Spermidine supplementation improved hippocampus-dependent discrimination memory in this small sample of individuals with SCD. Possible mechanisms of action include the stimulation of neuroprotective pathways through autophagy to restore neuronal function in memory-relevant networks. Longer-term intervention studies will help to validate the therapeutic potential of nutritional spermidine on memory and other cognitive domains along with underlying neuronal mechanisms of action in the at risk aging population." @default.
- W2897428465 created "2018-10-26" @default.
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- W2897428465 date "2018-07-01" @default.
- W2897428465 modified "2023-10-16" @default.
- W2897428465 title "O1‐12‐03: SPERMIDINE SUPPLEMENTATION TO IMPROVE EPISODIC MEMORY IN AGING ADULTS AT RISK OF DEMENTIA" @default.
- W2897428465 doi "https://doi.org/10.1016/j.jalz.2018.06.2398" @default.
- W2897428465 hasPublicationYear "2018" @default.
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