Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897431609> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2897431609 abstract "Prion (PrPC) is an endogenous protein found mainly in the nervous system, and its misfolded isoform (PrPSc) is associated with a group of neurodegenerative disorders known as transmissible spongiform encephalopathies, or simply prion diseases. The PrPSc isoform shows an intriguing ability to self-perpetuate, acting as template for PrPC misfolding and consequent aggregation. Aggregation in vitro and in vivo follows a fibrillation processes that is associated with neurodegeneration. Therefore, it is important to investigate and understand the molecular mechanisms involved in this process; such understanding also allows investigation of the action of possible candidate molecules to inhibit this process. Here, we highlight useful in vitro methodologies and analyses that were developed using PrP as a protein model but that, as other amyloid proteins also exhibit the same behavior, may be applied to understand other prion-like diseases such as Alzheimer's and Parkinson's disease." @default.
- W2897431609 created "2018-10-26" @default.
- W2897431609 creator A5054367986 @default.
- W2897431609 creator A5084615167 @default.
- W2897431609 date "2018-10-20" @default.
- W2897431609 modified "2023-09-23" @default.
- W2897431609 title "In Vitro Prion Amplification Methodology for Inhibitor Screening" @default.
- W2897431609 cites W1965420960 @default.
- W2897431609 cites W1991424179 @default.
- W2897431609 cites W2001748768 @default.
- W2897431609 cites W2005918656 @default.
- W2897431609 cites W2010462701 @default.
- W2897431609 cites W2011582248 @default.
- W2897431609 cites W2056785199 @default.
- W2897431609 cites W2068334126 @default.
- W2897431609 cites W2094140697 @default.
- W2897431609 cites W2120671345 @default.
- W2897431609 cites W2127178575 @default.
- W2897431609 cites W2324660492 @default.
- W2897431609 cites W2409975579 @default.
- W2897431609 cites W2426344673 @default.
- W2897431609 cites W2515234645 @default.
- W2897431609 cites W2530396506 @default.
- W2897431609 cites W2575088376 @default.
- W2897431609 cites W2605913901 @default.
- W2897431609 cites W2748622848 @default.
- W2897431609 cites W2767039008 @default.
- W2897431609 cites W2768372887 @default.
- W2897431609 doi "https://doi.org/10.1007/978-1-4939-8820-4_20" @default.
- W2897431609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30341619" @default.
- W2897431609 hasPublicationYear "2018" @default.
- W2897431609 type Work @default.
- W2897431609 sameAs 2897431609 @default.
- W2897431609 citedByCount "3" @default.
- W2897431609 countsByYear W28974316092019 @default.
- W2897431609 countsByYear W28974316092021 @default.
- W2897431609 countsByYear W28974316092022 @default.
- W2897431609 crossrefType "book-chapter" @default.
- W2897431609 hasAuthorship W2897431609A5054367986 @default.
- W2897431609 hasAuthorship W2897431609A5084615167 @default.
- W2897431609 hasConcept C104317684 @default.
- W2897431609 hasConcept C136238340 @default.
- W2897431609 hasConcept C142724271 @default.
- W2897431609 hasConcept C169760540 @default.
- W2897431609 hasConcept C185592680 @default.
- W2897431609 hasConcept C202751555 @default.
- W2897431609 hasConcept C207001950 @default.
- W2897431609 hasConcept C2776735649 @default.
- W2897431609 hasConcept C2776797465 @default.
- W2897431609 hasConcept C2776925932 @default.
- W2897431609 hasConcept C2777633098 @default.
- W2897431609 hasConcept C2779134260 @default.
- W2897431609 hasConcept C3019804061 @default.
- W2897431609 hasConcept C53345823 @default.
- W2897431609 hasConcept C54355233 @default.
- W2897431609 hasConcept C55493867 @default.
- W2897431609 hasConcept C59822182 @default.
- W2897431609 hasConcept C71924100 @default.
- W2897431609 hasConcept C86803240 @default.
- W2897431609 hasConcept C95444343 @default.
- W2897431609 hasConceptScore W2897431609C104317684 @default.
- W2897431609 hasConceptScore W2897431609C136238340 @default.
- W2897431609 hasConceptScore W2897431609C142724271 @default.
- W2897431609 hasConceptScore W2897431609C169760540 @default.
- W2897431609 hasConceptScore W2897431609C185592680 @default.
- W2897431609 hasConceptScore W2897431609C202751555 @default.
- W2897431609 hasConceptScore W2897431609C207001950 @default.
- W2897431609 hasConceptScore W2897431609C2776735649 @default.
- W2897431609 hasConceptScore W2897431609C2776797465 @default.
- W2897431609 hasConceptScore W2897431609C2776925932 @default.
- W2897431609 hasConceptScore W2897431609C2777633098 @default.
- W2897431609 hasConceptScore W2897431609C2779134260 @default.
- W2897431609 hasConceptScore W2897431609C3019804061 @default.
- W2897431609 hasConceptScore W2897431609C53345823 @default.
- W2897431609 hasConceptScore W2897431609C54355233 @default.
- W2897431609 hasConceptScore W2897431609C55493867 @default.
- W2897431609 hasConceptScore W2897431609C59822182 @default.
- W2897431609 hasConceptScore W2897431609C71924100 @default.
- W2897431609 hasConceptScore W2897431609C86803240 @default.
- W2897431609 hasConceptScore W2897431609C95444343 @default.
- W2897431609 hasLocation W28974316091 @default.
- W2897431609 hasLocation W28974316092 @default.
- W2897431609 hasOpenAccess W2897431609 @default.
- W2897431609 hasPrimaryLocation W28974316091 @default.
- W2897431609 hasRelatedWork W2058712059 @default.
- W2897431609 hasRelatedWork W2058787955 @default.
- W2897431609 hasRelatedWork W2090766888 @default.
- W2897431609 hasRelatedWork W2104485246 @default.
- W2897431609 hasRelatedWork W2129593365 @default.
- W2897431609 hasRelatedWork W2167944154 @default.
- W2897431609 hasRelatedWork W2277788469 @default.
- W2897431609 hasRelatedWork W2554407094 @default.
- W2897431609 hasRelatedWork W4206676400 @default.
- W2897431609 hasRelatedWork W4289921926 @default.
- W2897431609 isParatext "false" @default.
- W2897431609 isRetracted "false" @default.
- W2897431609 magId "2897431609" @default.
- W2897431609 workType "book-chapter" @default.