FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897432834> ?p ?o ?g. }

• W2897432834 endingPage "e11" @default.
• W2897432834 startingPage "e10" @default.
• W2897432834 abstract "Anal adenocarcinoma (AA) is an uncommon malignancy and is thought to carry a worse prognosis than anal squamous cell carcinoma (AS). There are currently no evidence-based recommendations on the proper management of AA, though it is typically treated similarly to a low-lying rectal adenocarcinoma. The purpose of this study was to evaluate the survival outcomes and patterns of management of AA using the National Cancer Data Base (NCDB) to determine if specific treatment paradigms result in improved outcomes. We hypothesize AA has worse survival outcomes and a different pattern of management compared to AS. The NCDB was queried (2004-2015) for patients with newly diagnosed nonmetastatic anal cancer treated with upfront chemoradiation. Patients were divided into two groups (either AA or AS) based on their histology. Statistics included Fisher’s exact or χ2 test to analyze categorical proportions in demographic information between adenocarcinoma and squamous cell carcinoma, Kaplan-Meier analysis to evaluate overall survival (OS), and Cox proportional hazards modeling to determine variables associated with OS. A total of 24,461 patients met selection criteria, of which 1,183 (4.8%) had adenocarcinoma, while 23,278 (95.2%) had squamous cell carcinoma. As compared to squamous cell carcinoma, patients with AA were more likely to present at an older age (>65), present at a more advanced stage, be of male sex, and undergo abdominoperineal resection (APR). Out of AA patients undergoing APR, 96.2% underwent APR within 6 months of completion of upfront chemoradiation (CRT). The median OS of AA patients was 72.5 months versus 143.8 months (P <0.001) for patients with AS. Amongst all AA patients, survival was greater for those undergoing APR within 6 months of CRT (88.3 months vs 58.1 months, P <0.001). On multivariate analysis, adenocarcinoma histology, age ≥55, male sex, T stage ≥3, Charlson-Deyo Score ≥1, lower socioeconomic status, and receipt of treatment at a non-academic facility were associated with worse OS. Adenocarcinoma of the anus is a rare and highly aggressive cancer. This is the largest study of AA to date and our findings suggest that this disease be managed similar to low- lying rectal cancers, as chemoradiation followed by prompt abdominoperineal resection is associated with improved survival outcomes." @default.
• W2897432834 created "2018-10-26" @default.
• W2897432834 creator A5024670184 @default.
• W2897432834 creator A5037000397 @default.
• W2897432834 creator A5047254884 @default.
• W2897432834 creator A5087527647 @default.
• W2897432834 date "2018-11-01" @default.
• W2897432834 modified "2023-10-16" @default.
• W2897432834 title "Survival Outcomes and Patterns of Management for Anal Adenocarcinoma: An Analysis of the National Cancer Data Base" @default.
• W2897432834 doi "https://doi.org/10.1016/j.ijrobp.2018.07.215" @default.
• W2897432834 hasPublicationYear "2018" @default.
• W2897432834 type Work @default.
• W2897432834 sameAs 2897432834 @default.
• W2897432834 citedByCount "0" @default.
• W2897432834 crossrefType "journal-article" @default.
• W2897432834 hasAuthorship W2897432834A5024670184 @default.
• W2897432834 hasAuthorship W2897432834A5037000397 @default.
• W2897432834 hasAuthorship W2897432834A5047254884 @default.
• W2897432834 hasAuthorship W2897432834A5087527647 @default.
• W2897432834 hasConcept C10515644 @default.
• W2897432834 hasConcept C121608353 @default.
• W2897432834 hasConcept C126322002 @default.
• W2897432834 hasConcept C143998085 @default.
• W2897432834 hasConcept C146357865 @default.
• W2897432834 hasConcept C151730666 @default.
• W2897432834 hasConcept C191093355 @default.
• W2897432834 hasConcept C2777546739 @default.
• W2897432834 hasConcept C2779399171 @default.
• W2897432834 hasConcept C2779840525 @default.
• W2897432834 hasConcept C2780035688 @default.
• W2897432834 hasConcept C2781074409 @default.
• W2897432834 hasConcept C2781171867 @default.
• W2897432834 hasConcept C2781182431 @default.
• W2897432834 hasConcept C50382708 @default.
• W2897432834 hasConcept C526805850 @default.
• W2897432834 hasConcept C71924100 @default.
• W2897432834 hasConcept C86803240 @default.
• W2897432834 hasConceptScore W2897432834C10515644 @default.
• W2897432834 hasConceptScore W2897432834C121608353 @default.
• W2897432834 hasConceptScore W2897432834C126322002 @default.
• W2897432834 hasConceptScore W2897432834C143998085 @default.
• W2897432834 hasConceptScore W2897432834C146357865 @default.
• W2897432834 hasConceptScore W2897432834C151730666 @default.
• W2897432834 hasConceptScore W2897432834C191093355 @default.
• W2897432834 hasConceptScore W2897432834C2777546739 @default.
• W2897432834 hasConceptScore W2897432834C2779399171 @default.
• W2897432834 hasConceptScore W2897432834C2779840525 @default.
• W2897432834 hasConceptScore W2897432834C2780035688 @default.
• W2897432834 hasConceptScore W2897432834C2781074409 @default.
• W2897432834 hasConceptScore W2897432834C2781171867 @default.
• W2897432834 hasConceptScore W2897432834C2781182431 @default.
• W2897432834 hasConceptScore W2897432834C50382708 @default.
• W2897432834 hasConceptScore W2897432834C526805850 @default.
• W2897432834 hasConceptScore W2897432834C71924100 @default.
• W2897432834 hasConceptScore W2897432834C86803240 @default.
• W2897432834 hasIssue "3" @default.
• W2897432834 hasLocation W28974328341 @default.
• W2897432834 hasOpenAccess W2897432834 @default.
• W2897432834 hasPrimaryLocation W28974328341 @default.
• W2897432834 hasRelatedWork W1973496321 @default.
• W2897432834 hasRelatedWork W2021106445 @default.
• W2897432834 hasRelatedWork W2080671488 @default.
• W2897432834 hasRelatedWork W2082960939 @default.
• W2897432834 hasRelatedWork W2154326194 @default.
• W2897432834 hasRelatedWork W2355800705 @default.
• W2897432834 hasRelatedWork W2372105188 @default.
• W2897432834 hasRelatedWork W3022070425 @default.
• W2897432834 hasRelatedWork W3172486966 @default.
• W2897432834 hasRelatedWork W4239980826 @default.
• W2897432834 hasVolume "102" @default.
• W2897432834 isParatext "false" @default.
• W2897432834 isRetracted "false" @default.
• W2897432834 magId "2897432834" @default.
• W2897432834 workType "article" @default.