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• W2897434296 abstract "Efficient DNA repair is indispensable for maintaining genomic integrity in humans. Cancer associated deletions and mutations are mainly due to misrepaired DNA double-strand breaks (DSBs). Classical nonhomologous end joining (c-NHEJ) and homologous recombination (HR) are two major DSB repair pathways in humans. An error prone, alternative NHEJ pathway that utilizes microhomology was also reported in cancer cells and to a lesser extent in normal cells. In the present study, we evaluated the efficiency of various DSB repair pathways in the most common lymphoma, the diffuse large B cell lymphoma (DLBCL). Here we show that DNA repair through c-NHEJ pathway is limited in SUDHL8, a cell line derived from a DLBCL patient. Unlike c-NHEJ, microhomology mediated end joining (MMEJ) was predominant at physiological temperature. Consistent with the observation, expression level of repair proteins such as LIGASE I, LIGASE III, PARP1, CtIP, and MRE11 was higher in DLBCL cells when compared to c-NHEJ proteins. Further, inhibition of LIGASE I or MRE11, led to reduction in the efficiency of MMEJ in DLBCL cells. Besides, HR-mediated DSB repair occurring through gene conversion was observed. Thus, our results reveal the predominance of MMEJ over c-NHEJ in repairing DSBs in DLBCL cells, while error-free repair through HR was also evident." @default.
• W2897434296 created "2018-10-26" @default.
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• W2897434296 date "2018-10-25" @default.
• W2897434296 modified "2023-09-24" @default.
• W2897434296 title "Characterization of DNA double-strand break repair pathways in diffuse large B cell lymphoma" @default.
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• W2897434296 doi "https://doi.org/10.1002/mc.22921" @default.
• W2897434296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30298948" @default.
• W2897434296 hasPublicationYear "2018" @default.
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