FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897434733> ?p ?o ?g. }

• W2897434733 endingPage "e0203907" @default.
• W2897434733 startingPage "e0203907" @default.
• W2897434733 abstract "Herbal extracts represent an ample source of natural compounds, with potential to be used in improving human health. There is a growing interest in using natural extracts as possible new treatment strategies for inflammatory diseases. We therefore aimed at identifying herbal extracts that affect inflammatory signaling pathways through toll-like receptors (TLRs), TLR2 and TLR4. Ninety-nine ethanolic extracts were screened in THP-1 monocytes and HeLa-TLR4 transfected reporter cells for their effects on stimulated TLR2 and TLR4 signaling pathways. The 28 identified anti-inflammatory extracts were tested in comparative assays of stimulated HEK-TLR2 and HEK-TLR4 transfected reporter cells to differentiate between direct TLR4 antagonistic effects and interference with downstream signaling cascades. Furthermore, the ten most effective anti-inflammatory extracts were tested on their ability to inhibit nuclear factor-κB (NF-κB) translocation in HeLa-TLR4 transfected reporter cell lines and for their ability to repolarize M1-type macrophages. Ethanolic extracts which showed the highest anti-inflammatory potential, up to a complete inhibition of pro-inflammatory cytokine production were Castanea sativa leaves, Cinchona pubescens bark, Cinnamomum verum bark, Salix alba bark, Rheum palmatum root, Alchemilla vulgaris plant, Humulus lupulus cones, Vaccinium myrtillus berries, Curcuma longa root and Arctostaphylos uva-ursi leaves. Moreover, all tested extracts mitigated not only TLR4, but also TLR2 signaling pathways. Seven of them additionally inhibited translocation of NF-κB into the nucleus. Two of the extracts showed impact on repolarization of pro-inflammatory M1-type to anti-inflammatory M2-type macrophages. Several promising anti-inflammatory herbal extracts were identified in this study, including extracts with previously unknown influence on key TLR signaling pathways and macrophage repolarization, serving as a basis for novel lead compound identification." @default.
• W2897434733 created "2018-10-26" @default.
• W2897434733 creator A5004357895 @default.
• W2897434733 creator A5022092357 @default.
• W2897434733 creator A5034561426 @default.
• W2897434733 creator A5036563516 @default.
• W2897434733 creator A5053313467 @default.
• W2897434733 creator A5057353442 @default.
• W2897434733 creator A5057359066 @default.
• W2897434733 creator A5061038771 @default.
• W2897434733 creator A5062579835 @default.
• W2897434733 creator A5078826627 @default.
• W2897434733 creator A5089367755 @default.
• W2897434733 date "2018-10-11" @default.
• W2897434733 modified "2023-10-01" @default.
• W2897434733 title "Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects" @default.
• W2897434733 cites W106125267 @default.
• W2897434733 cites W1441835895 @default.
• W2897434733 cites W1487101581 @default.
• W2897434733 cites W1515590569 @default.
• W2897434733 cites W1536400911 @default.
• W2897434733 cites W1552939846 @default.
• W2897434733 cites W1829699025 @default.
• W2897434733 cites W1839089902 @default.
• W2897434733 cites W1852359153 @default.
• W2897434733 cites W1964431874 @default.
• W2897434733 cites W1970335548 @default.
• W2897434733 cites W1970406868 @default.
• W2897434733 cites W1972522424 @default.
• W2897434733 cites W1981262534 @default.
• W2897434733 cites W1985390439 @default.
• W2897434733 cites W1985425748 @default.
• W2897434733 cites W1988200243 @default.
• W2897434733 cites W1989038593 @default.
• W2897434733 cites W1990261712 @default.
• W2897434733 cites W2001930254 @default.
• W2897434733 cites W2002086112 @default.
• W2897434733 cites W2003258928 @default.
• W2897434733 cites W2005001748 @default.
• W2897434733 cites W2007086998 @default.
• W2897434733 cites W2010633716 @default.
• W2897434733 cites W2018399989 @default.
• W2897434733 cites W2024110631 @default.
• W2897434733 cites W2024138259 @default.
• W2897434733 cites W2026950982 @default.
• W2897434733 cites W2030846061 @default.
• W2897434733 cites W2037339629 @default.
• W2897434733 cites W2041747140 @default.
• W2897434733 cites W2042815338 @default.
• W2897434733 cites W2047067920 @default.
• W2897434733 cites W2055959953 @default.
• W2897434733 cites W2057244872 @default.
• W2897434733 cites W2061260410 @default.
• W2897434733 cites W2064206229 @default.
• W2897434733 cites W2068917566 @default.
• W2897434733 cites W2072624469 @default.
• W2897434733 cites W2078537681 @default.
• W2897434733 cites W2082092717 @default.
• W2897434733 cites W2089910376 @default.
• W2897434733 cites W2094563797 @default.
• W2897434733 cites W2094823102 @default.
• W2897434733 cites W2096866512 @default.
• W2897434733 cites W2102160308 @default.
• W2897434733 cites W2108919922 @default.
• W2897434733 cites W2118400571 @default.
• W2897434733 cites W2124439764 @default.
• W2897434733 cites W2132137833 @default.
• W2897434733 cites W2135759216 @default.
• W2897434733 cites W2138167941 @default.
• W2897434733 cites W2152153752 @default.
• W2897434733 cites W2199395920 @default.
• W2897434733 cites W2294344816 @default.
• W2897434733 cites W2350266534 @default.
• W2897434733 cites W2498625703 @default.
• W2897434733 cites W2519916383 @default.
• W2897434733 cites W2564165348 @default.
• W2897434733 cites W2572596693 @default.
• W2897434733 cites W2578611753 @default.
• W2897434733 cites W2581606583 @default.
• W2897434733 cites W2593587512 @default.
• W2897434733 cites W2603442135 @default.
• W2897434733 cites W2738804469 @default.
• W2897434733 cites W2745954137 @default.
• W2897434733 cites W2752785005 @default.
• W2897434733 cites W2765449524 @default.
• W2897434733 cites W2766931652 @default.
• W2897434733 cites W2778598164 @default.
• W2897434733 cites W2784230746 @default.
• W2897434733 cites W2791105356 @default.
• W2897434733 doi "https://doi.org/10.1371/journal.pone.0203907" @default.
• W2897434733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6181297" @default.
• W2897434733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307962" @default.
• W2897434733 hasPublicationYear "2018" @default.
• W2897434733 type Work @default.
• W2897434733 sameAs 2897434733 @default.
• W2897434733 citedByCount "43" @default.
• W2897434733 countsByYear W28974347332019 @default.
• W2897434733 countsByYear W28974347332020 @default.

• next