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• W2897442755 abstract "Given the lack of pharmacological treatments for impaired cognition, and a projected increased prevalence of dementia, there is considerable interest in examining the role of diet in preventing neurodegeneration. However, evidence is currently limited and has rarely been systematically reviewed, particularly in a Mild Cognitive Impairment (MCI) population. This systematic review aimed to examine the effect of diet on cognitive outcomes in MCI patients. MEDLINE, EMBASE, PsycINFO, Web of Science and Scopus were systematically searched to identify randomised controlled trials (RCT), with diet as the main focus of the intervention, in MCI participants. The primary outcome was incident dementia and/or Alzheimer's disease (AD) and, secondary outcomes included cognitive function across different domains using validated neuropsychological tests. Data extraction and assessment of quality were performed by two independent reviewers and data were summarized using a narrative review. Twelve studies met the inclusion criteria, with a high degree of heterogeneity relating to the nature of the dietary intervention and cognitive outcomes measured, thus making comparisons difficult and precluded pooling of studies for meta-analysis. For methodological quality, n=7 studies were allocated a low to moderate quality score (Jadad et al., 1996). Overall, it was evident that the findings were inconsistent across the studies and do not provide clear evidence to support the effect of diet on cognition in MCIpatients. Supplementation with either Vitamin E or Ginkgo Biloba, had no significant effect on progression from MCI to dementia and/or AD. For cognitive function, there were some improvements in cognitive performance, particularly in the domain of memory, with the most consistent results shown by B vitamin, folic acid and cocoa flavonol supplementation. Furthermore, there were indications that the use of neuroimaging and biomarker outcome measures may provide a more sensitive approach to detect changes in cognitive function and dietary change in comparison to clinical tests. This systematic review highlighted that to date, there is insufficient clinical trial data on the effect of diet on cognitive outcomes in MCI patients. There is need for further well-designed RCTs, with standardised and robust measures of cognition to further explore the role of diet in cognitive decline." @default.
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• W2897442755 date "2018-07-01" @default.
• W2897442755 modified "2023-10-16" @default.
• W2897442755 title "P4‐176: THE EFFECT OF DIETARY INTERVENTIONS IN MILD COGNITIVE IMPAIRMENT: A SYSTEMATIC REVIEW" @default.
• W2897442755 doi "https://doi.org/10.1016/j.jalz.2018.06.2581" @default.
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