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• W2897450030 endingPage "204" @default.
• W2897450030 startingPage "190" @default.
• W2897450030 abstract "Inflammatory skin diseases treatments currently used cause adverse effects. Nasturtium officinale (watercress) is used popularly as an anti-inflammatory. However, until now, no study proved its effectiveness as a topical treatment to inflammatory skin diseases. The topical anti-inflammatory activity of N. officinale crude extract leaves (NoE) on an irritant contact dermatitis (ICD) model croton oil-induced in mice was investigated. ICD models were induced by a single (1 mg/ear; acute) or repeated (0.4 mg/ear; chronic; 9 days total) croton oil application. NoE and dexamethasone solutions’ (diluted in acetone; 20 μL/ear) or NoE gel, dexamethasone gel and base gel (15 mg/ear) were topically applied immediately after croton oil application. The NoE topical anti-inflammatory effect was evaluated for inflammatory parameters (ear edema, inflammatory cells infiltration, and inflammatory cytokines levels). NoE topical anti-inflammatory mechanism (NF-κB pathway and effect glucocorticoid-like) were assessed by western blot and ear edema analyses, respectively. UHPLC-MS/MS chromatography, gels accelerated stability and preliminary study of adverse effects was also performed. UHPLC-MS/MS of the NoE revealed the presence of coumaric acid, rutin, and ferulic acid. NoE gels stability study showed no relevant changes at low temperature. NoE, dexamethasone, NoE gel and dexamethasone gel inhibited the ear edema croton oil-induced by 82 ± 6% (1 mg/ear), 99 ± 1% (0.1 mg/ear), 81 ± 8% (3%) and 70 ± 6% (0.5%) for the acute model, and 49 ± 7% (1 mg/ear), 80 ± 4% (0.1 mg/ear), 41 ± 8% (3%) and 46 ± 14% (0.5%) for the chronic model, respectively. The same treatments also reduced the inflammatory cells infiltration by 62 ± 3% (1 mg/ear), 97 ± 2% (0.1 mg/ear), 60 ± 3% (3%) and 66 ± 6% (0.5%) for the acute model, respectively, and 25 ± 8% (1 mg/ear) to NoE and 83 ± 13% to dexamethasone to the chronic model. NoE and NoE gel reduced the pro-inflammatory cytokines levels (acute ICD model) by 62 ± 5% and 71 ± 3% (MIP-2) and 32 ± 3% and 44 ± 4% (IL-1β), while dexamethasone solution's and gel reduced by 79 ± 7% and 44 ± 4% to MIP-2 and 98 ± 2% and 83 ± 9% to IL-1β, respectively. NoE’ and dexamethasone’ solutions inhibited the reduction of IkB-α protein expression induced by croton oil by 100% and 80 ± 14%, respectively. Besides, the mifepristone (glucocorticoid receptor antagonist) pre-treatment prevented the topical anti-edematogenic effect of NoE’ and dexamethasone’ solutions by 61 ± 5% to NoE and 78 ± 16% to dexamethasone. The repeated topical application of NoE did not cause adverse effects. Our results suggest the N. officinale use in the cutaneous inflammatory process treatment and demonstrate the NoE potential to develop a promising topical anti-inflammatory agent to treat inflammatory disorders." @default.
• W2897450030 created "2018-10-26" @default.
• W2897450030 creator A5004300393 @default.
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• W2897450030 creator A5069590946 @default.
• W2897450030 date "2019-01-01" @default.
• W2897450030 modified "2023-10-17" @default.
• W2897450030 title "Nasturtium officinale R. Br. effectively reduces the skin inflammation induced by croton oil via glucocorticoid receptor-dependent and NF-κB pathways without causing toxicological effects in mice" @default.
• W2897450030 cites W1247569718 @default.
• W2897450030 cites W1545348542 @default.
• W2897450030 cites W1552305698 @default.
• W2897450030 cites W1598515492 @default.
• W2897450030 cites W1825067546 @default.
• W2897450030 cites W1869999849 @default.
• W2897450030 cites W1916800927 @default.
• W2897450030 cites W1942733542 @default.
• W2897450030 cites W1965246148 @default.
• W2897450030 cites W1967289579 @default.
• W2897450030 cites W1967337248 @default.
• W2897450030 cites W1967363201 @default.
• W2897450030 cites W1969260205 @default.
• W2897450030 cites W1973085329 @default.
• W2897450030 cites W1973910302 @default.
• W2897450030 cites W1974532920 @default.
• W2897450030 cites W1978004223 @default.
• W2897450030 cites W1978697461 @default.
• W2897450030 cites W1983167592 @default.
• W2897450030 cites W1985156522 @default.
• W2897450030 cites W1986395265 @default.
• W2897450030 cites W1991789911 @default.
• W2897450030 cites W1992716708 @default.
• W2897450030 cites W1994103575 @default.
• W2897450030 cites W1997490604 @default.
• W2897450030 cites W2002851339 @default.
• W2897450030 cites W2012104203 @default.
• W2897450030 cites W2012598134 @default.
• W2897450030 cites W2016711291 @default.
• W2897450030 cites W2019770562 @default.
• W2897450030 cites W2021233343 @default.
• W2897450030 cites W2026403052 @default.
• W2897450030 cites W2031159089 @default.
• W2897450030 cites W2037462205 @default.
• W2897450030 cites W2039800741 @default.
• W2897450030 cites W2040571395 @default.
• W2897450030 cites W2040992929 @default.
• W2897450030 cites W2049651957 @default.
• W2897450030 cites W2053199642 @default.
• W2897450030 cites W2054083814 @default.
• W2897450030 cites W2058824214 @default.
• W2897450030 cites W2062528883 @default.
• W2897450030 cites W2065155058 @default.
• W2897450030 cites W2066763521 @default.
• W2897450030 cites W2066794106 @default.
• W2897450030 cites W2070599134 @default.
• W2897450030 cites W2071071686 @default.
• W2897450030 cites W2071437648 @default.
• W2897450030 cites W2078390802 @default.
• W2897450030 cites W2078856508 @default.
• W2897450030 cites W2090267463 @default.
• W2897450030 cites W2107994133 @default.
• W2897450030 cites W2113307189 @default.
• W2897450030 cites W2116796494 @default.
• W2897450030 cites W2130353405 @default.
• W2897450030 cites W2144687284 @default.
• W2897450030 cites W2160068319 @default.
• W2897450030 cites W2161780474 @default.
• W2897450030 cites W2174018465 @default.
• W2897450030 cites W2175927969 @default.
• W2897450030 cites W2217087387 @default.
• W2897450030 cites W2270107767 @default.
• W2897450030 cites W2275125395 @default.
• W2897450030 cites W2294990983 @default.
• W2897450030 cites W2324370786 @default.
• W2897450030 cites W2407567293 @default.
• W2897450030 cites W2418800924 @default.
• W2897450030 cites W2433564581 @default.
• W2897450030 cites W2503583803 @default.
• W2897450030 cites W2506630114 @default.
• W2897450030 cites W2508203573 @default.
• W2897450030 cites W2531224700 @default.
• W2897450030 cites W2547217201 @default.
• W2897450030 cites W2550278362 @default.
• W2897450030 cites W2551075488 @default.
• W2897450030 cites W2566527809 @default.
• W2897450030 cites W2566706476 @default.
• W2897450030 cites W2567559321 @default.
• W2897450030 cites W2582101902 @default.
• W2897450030 cites W2618548384 @default.
• W2897450030 cites W2747330933 @default.
• W2897450030 cites W2775302672 @default.
• W2897450030 cites W2738656239 @default.
• W2897450030 doi "https://doi.org/10.1016/j.jep.2018.10.011" @default.

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