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- W2897457022 abstract "Abstract Larval Galleria mellonella (L.) hemocytes form microaggregates in response to stimulation by Gram‐positive bacteria. Hemocyte adhesion to foreign materials is mediated by the cAMP/ protein kinase A pathway and the β‐subunit of cholera toxin using a cAMP‐independent mechanism. Cholera toxin‐induced microaggregation was inhibited by the integrin inhibitory RGDS peptide, implying integrins may be part of the mechanism. Based on the types of mammalian integrin‐antibody reactive proteins affecting hemocyte adhesion and bacterial‐induced responses α 5 , α v , β 1 , and β 3 subunits occurred on both granular cell and plasmatocyte hemocyte subtypes. A fluorescent band representing the binding of rabbit α 5 ‐integrin subunit antibodies occurred between adhering heterotypic hemocytes. The frequency of the bands was increased by cholera toxin. The α 5 and β 1 rabbit integrin subunit antibodies inhibited removal of Bacillus subtilis (Cohn) from the hemolymph in vivo . A α 5 β 1 ‐specific synthetic peptide blocker similarly diminished hemocyte function whereas the α v β 3 ‐specific inhibitory peptide and the corresponding integrin subunit antibodies did not influence nonself hemocyte activities. Western blots revealed several proteins reacting with a given integrin‐antibody subtype. Thus integrin‐antibody reactive proteins (which may include integrins) with possible α 5 and β 1 epitopes modulate immediate hemocyte function. Confocal microscopy established plasmatocyte adhesion to and rosetting over substrata followed by granular cell microaggregate adhesion to plasmatocytes during early stage nodulation." @default.
- W2897457022 created "2018-10-26" @default.
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- W2897457022 date "2018-11-20" @default.
- W2897457022 modified "2023-09-27" @default.
- W2897457022 title "Physiological evidence of integrin‐antibody reactive proteins influencing the innate cellular immune responses of larval <i>Galleria mellonella</i> hemocytes" @default.
- W2897457022 cites W1489303522 @default.
- W2897457022 cites W1576773659 @default.
- W2897457022 cites W1815175398 @default.
- W2897457022 cites W1948838079 @default.
- W2897457022 cites W1964225390 @default.
- W2897457022 cites W1965389967 @default.
- W2897457022 cites W1966765683 @default.
- W2897457022 cites W1967518124 @default.
- W2897457022 cites W1969344089 @default.
- W2897457022 cites W1970276079 @default.
- W2897457022 cites W1974071443 @default.
- W2897457022 cites W1975503588 @default.
- W2897457022 cites W1979552261 @default.
- W2897457022 cites W1982416229 @default.
- W2897457022 cites W1985956538 @default.
- W2897457022 cites W1988724295 @default.
- W2897457022 cites W1990734508 @default.
- W2897457022 cites W1991894986 @default.
- W2897457022 cites W1995905074 @default.
- W2897457022 cites W2000592560 @default.
- W2897457022 cites W2002479879 @default.
- W2897457022 cites W2003587139 @default.
- W2897457022 cites W2006239474 @default.
- W2897457022 cites W2008292476 @default.
- W2897457022 cites W2018020399 @default.
- W2897457022 cites W2020821162 @default.
- W2897457022 cites W2024656166 @default.
- W2897457022 cites W2025016743 @default.
- W2897457022 cites W2025272386 @default.
- W2897457022 cites W2025926359 @default.
- W2897457022 cites W2025985464 @default.
- W2897457022 cites W2031172658 @default.
- W2897457022 cites W2036026330 @default.
- W2897457022 cites W2037508363 @default.
- W2897457022 cites W2039676996 @default.
- W2897457022 cites W2040108099 @default.
- W2897457022 cites W2044344067 @default.
- W2897457022 cites W2045128082 @default.
- W2897457022 cites W2059658347 @default.
- W2897457022 cites W2062083343 @default.
- W2897457022 cites W2066196795 @default.
- W2897457022 cites W2066215505 @default.
- W2897457022 cites W2067589679 @default.
- W2897457022 cites W2067889867 @default.
- W2897457022 cites W2067916061 @default.
- W2897457022 cites W2068533636 @default.
- W2897457022 cites W2069384743 @default.
- W2897457022 cites W2069875605 @default.
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- W2897457022 cites W2078275307 @default.
- W2897457022 cites W2080413710 @default.
- W2897457022 cites W2081685367 @default.
- W2897457022 cites W2083238952 @default.
- W2897457022 cites W2086191392 @default.
- W2897457022 cites W2088044909 @default.
- W2897457022 cites W2096447749 @default.
- W2897457022 cites W2103521171 @default.
- W2897457022 cites W2111657038 @default.
- W2897457022 cites W2114286636 @default.
- W2897457022 cites W2115954099 @default.
- W2897457022 cites W2125216100 @default.
- W2897457022 cites W2129773451 @default.
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- W2897457022 cites W2138501465 @default.
- W2897457022 cites W2158850412 @default.
- W2897457022 cites W2169554406 @default.
- W2897457022 cites W2171777085 @default.
- W2897457022 cites W2181295289 @default.
- W2897457022 cites W4293247451 @default.
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- W2897457022 doi "https://doi.org/10.1111/1744-7917.12646" @default.
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