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• W2897460504 abstract "Pegylated asparaginase (PEG-Asp), a key component in the treatment of acute lymphoblastic leukemia (ALL), is associated with coagulopathy and an increased risk of venous thromboembolism (VTE). PEG-Asp also lowers antithrombin (AT) levels. Between April 2014 and October 2017, 75 adult ALL patients were identified to have received at least one dose of PEG-Asp. Patients were assigned to the AT group if a physician monitored AT levels with an intention to correct low AT levels (<60%). Incidence of VTE was not significantly different, with 17% (8/47) of the AT patients and 11% (3/28) of the control patients experiencing a VTE event (p = .52). The occurrence of coagulopathies was not significantly different. Within the AT group, 37 patients (78%) received AT, and median AT% prior to supplementation was 49%. The median number of AT doses received was 2 (range 0–12) and the mean cost of AT per patient was $11,847." @default.
• W2897460504 created "2018-10-26" @default.
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• W2897460504 date "2018-10-15" @default.
• W2897460504 modified "2023-10-01" @default.
• W2897460504 title "Antithrombin supplementation did not impact the incidence of pegylated asparaginase-induced venous thromboembolism in adults with acute lymphoblastic leukemia" @default.
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• W2897460504 doi "https://doi.org/10.1080/10428194.2018.1519811" @default.
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