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- W2897464479 abstract "Surgery followed by postoperative radiation therapy (RT) is the standard of care for soft tissue sarcomas (STS) of the head and neck that are high-grade or have close or positive margins. Here we report the outcomes of this rare tumor in adults. This is a retrospective review of adult patients with head and neck STS treated with RT between 1981 and 2017. All patients who were ≥ 19 years old with STS of the head and neck, excluding rhabdomyosarcoma and Ewing tumors, were included in this study. Toxicity was graded using CTCAE version 4. A total of 35 patients with head and neck STS treated with postoperative RT (32), primary RT (2), or preoperative RT (1) met the inclusion criteria. The median age at diagnosis was 54 years (range, 20-83). Overall, 69% had T1 tumors, 57% had high-grade histology (grade 3), and 26% had microscopically positive margins. The median RT dose was 66 Gy to the primary site; 43% received elective nodal irradiation. The median follow-up was 15.1 years (range, 0.5-28.2 years) for living patients. At 5 years and 10 years, the local control rates were 84% and 75%, the regional control rates were 100% and 100%, the freedom from distant metastases rates were 91% and 91%, the cause-specific survival rates were 82% and 74%, and the overall survival rates were 79% and 58%. Three patients (9%) developed late grade 3+ complications. Our study demonstrates that surgery and RT for STS of the head and neck cures 74% of patients at 10 years. Local failure is the most common form of recurrence influenced strongly by histologic grade and margin status." @default.
- W2897464479 created "2018-10-26" @default.
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- W2897464479 date "2018-11-01" @default.
- W2897464479 modified "2023-09-25" @default.
- W2897464479 title "Radiation Therapy for Adult Soft Tissue Sarcomas of the Head and Neck" @default.
- W2897464479 doi "https://doi.org/10.1016/j.ijrobp.2018.07.968" @default.
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