FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897466207> ?p ?o ?g. }

• W2897466207 abstract "Bryostatin, pre-clinically shown to induce synaptogenesis and prevent neuronal death, was evaluated via a double-blind, placebo-controlled trial with two doses (20 ug and 40 ug) of bryostatin compared to placebo. 150 subjects were randomized in a 1:1:1 treatment allocation. Each patient received initial doses 1 week apart, followed by every 2 weeks – for 11 weeks. The endpoints were severe impairment battery (SIB) scores at 0,5, 9, 13, and 15 weeks (30 days after the last dose). Because PKC epsilon, the target of bryostatin, controls NMDA function that is blocked by memantine, a pre-specified exploratory analysis of the treatment effect of Bryostatin for patients stratified by memantine usage, as a baseline therapy, was of particular interest. The initial primary efficacy analysis used a mixed model (MMRM) to handle missing data. However, since there were few missing observations for patients naïve to memantine, the complex MMRM modeling for analysis was not needed. Moreover, to avoid large potential intra-patient SIB variation over time, for the present analysis, we considered the change in average score collected during week 13-15 from baseline as the endpoint. The treatment effect estimate was based on the simple, transparent two-sample t-statistic for assessing the between-group-difference. In comparing 20 ug bryostatin with placebo for Memantine-naïve patients, the difference in SIB change from baseline was 6.1 points with 95% confidence interval of (1.5, 10.7) and p = 0.012, suggesting 20 ug bryostatin was highly significantly better than placebo. On the other hand, there was no treatment effect for memantine-dosed patients. Furthermore, with repeated measures of SIB over time for memantine-naïve patients, the 20ug bryostatin group showed early benefit starting at Week 5 and the positive trend was sustained for the entire study follow-up. The results of these new analyses are consistent with, although clearer than, previous analyses that indicated persistence of bryostatin benefit even 30 days after all dosing was completed. Bryostatin, without memantine, shows potential as a modifier of Alzheimer's disease – to be confirmed by additional studies." @default.
• W2897466207 created "2018-10-26" @default.
• W2897466207 creator A5040895261 @default.
• W2897466207 creator A5041206912 @default.
• W2897466207 creator A5043594157 @default.
• W2897466207 creator A5072355639 @default.
• W2897466207 date "2018-07-01" @default.
• W2897466207 modified "2023-10-16" @default.
• W2897466207 title "P4‐199: SIGNIFICANT COGNITIVE IMPROVEMENT WITH BRYOSTATIN FOR ADVANCED ALZHEIMER'S PATIENTS IN THE ABSENCE OF MEMANTINE" @default.
• W2897466207 doi "https://doi.org/10.1016/j.jalz.2018.07.020" @default.
• W2897466207 hasPublicationYear "2018" @default.
• W2897466207 type Work @default.
• W2897466207 sameAs 2897466207 @default.
• W2897466207 citedByCount "0" @default.
• W2897466207 crossrefType "journal-article" @default.
• W2897466207 hasAuthorship W2897466207A5040895261 @default.
• W2897466207 hasAuthorship W2897466207A5041206912 @default.
• W2897466207 hasAuthorship W2897466207A5043594157 @default.
• W2897466207 hasAuthorship W2897466207A5072355639 @default.
• W2897466207 hasConcept C102959455 @default.
• W2897466207 hasConcept C105795698 @default.
• W2897466207 hasConcept C126322002 @default.
• W2897466207 hasConcept C142724271 @default.
• W2897466207 hasConcept C168563851 @default.
• W2897466207 hasConcept C170493617 @default.
• W2897466207 hasConcept C203092338 @default.
• W2897466207 hasConcept C204787440 @default.
• W2897466207 hasConcept C27081682 @default.
• W2897466207 hasConcept C2779484449 @default.
• W2897466207 hasConcept C2910806222 @default.
• W2897466207 hasConcept C33923547 @default.
• W2897466207 hasConcept C42219234 @default.
• W2897466207 hasConcept C44249647 @default.
• W2897466207 hasConcept C67018056 @default.
• W2897466207 hasConcept C71924100 @default.
• W2897466207 hasConcept C88045685 @default.
• W2897466207 hasConcept C99476002 @default.
• W2897466207 hasConceptScore W2897466207C102959455 @default.
• W2897466207 hasConceptScore W2897466207C105795698 @default.
• W2897466207 hasConceptScore W2897466207C126322002 @default.
• W2897466207 hasConceptScore W2897466207C142724271 @default.
• W2897466207 hasConceptScore W2897466207C168563851 @default.
• W2897466207 hasConceptScore W2897466207C170493617 @default.
• W2897466207 hasConceptScore W2897466207C203092338 @default.
• W2897466207 hasConceptScore W2897466207C204787440 @default.
• W2897466207 hasConceptScore W2897466207C27081682 @default.
• W2897466207 hasConceptScore W2897466207C2779484449 @default.
• W2897466207 hasConceptScore W2897466207C2910806222 @default.
• W2897466207 hasConceptScore W2897466207C33923547 @default.
• W2897466207 hasConceptScore W2897466207C42219234 @default.
• W2897466207 hasConceptScore W2897466207C44249647 @default.
• W2897466207 hasConceptScore W2897466207C67018056 @default.
• W2897466207 hasConceptScore W2897466207C71924100 @default.
• W2897466207 hasConceptScore W2897466207C88045685 @default.
• W2897466207 hasConceptScore W2897466207C99476002 @default.
• W2897466207 hasIssue "7S_Part_29" @default.
• W2897466207 hasLocation W28974662071 @default.
• W2897466207 hasOpenAccess W2897466207 @default.
• W2897466207 hasPrimaryLocation W28974662071 @default.
• W2897466207 hasRelatedWork W2017549833 @default.
• W2897466207 hasRelatedWork W2017648622 @default.
• W2897466207 hasRelatedWork W2038926111 @default.
• W2897466207 hasRelatedWork W2128335588 @default.
• W2897466207 hasRelatedWork W2151156646 @default.
• W2897466207 hasRelatedWork W2255036156 @default.
• W2897466207 hasRelatedWork W2328827067 @default.
• W2897466207 hasRelatedWork W2474943826 @default.
• W2897466207 hasRelatedWork W2897466207 @default.
• W2897466207 hasRelatedWork W2983417283 @default.
• W2897466207 hasVolume "14" @default.
• W2897466207 isParatext "false" @default.
• W2897466207 isRetracted "false" @default.
• W2897466207 magId "2897466207" @default.
• W2897466207 workType "article" @default.