FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897467102> ?p ?o ?g. }

• W2897467102 abstract "Phage display-selected bicyclic peptides have already shown their great potential for the development as bioactive modulators of therapeutic targets. They can provide enhanced proteolytic stability and improved membrane permeability. Molecular design of new linker molecules has led to a variety of new synthetic approaches for the generation of chemically constrained cyclic peptides. This diversity can be useful for the development of novel peptide-based therapeutic, diagnostic, and scientific tools. Herein, we introduce 1,3,5-tris((pyridin-2-yldisulfanyl)methyl)benzene (TPSMB) as a planar, trivalent, sulfhydryl-specific linker that facilitates reversible cyclization and linearization via disulfide bond formation and cleavage of bicyclic peptides of the format CXnCXnC, where X is any proteinogenic amino acid except cysteine. The rapid and highly sulfhydryl-specific reaction of TPSMB under physiological conditions is demonstrated by selecting bicyclic peptide binders against c-Jun N-terminal kinase 3 (JNK3) as a model target. While model peptides remain stably cyclized for several hours in presence of typical blood levels of glutathione in vitro, high cytosolic concentrations of glutathione linearize these peptides completely within 1 h. We propose that reversible linkers can be useful tools for several technical applications where target affinity depends on the bicyclic structure of the peptide." @default.
• W2897467102 created "2018-10-26" @default.
• W2897467102 creator A5002907072 @default.
• W2897467102 creator A5015753523 @default.
• W2897467102 creator A5022428348 @default.
• W2897467102 creator A5054574030 @default.
• W2897467102 creator A5078094651 @default.
• W2897467102 creator A5086525697 @default.
• W2897467102 creator A5089643377 @default.
• W2897467102 date "2018-10-16" @default.
• W2897467102 modified "2023-09-29" @default.
• W2897467102 title "Switching Between Bicyclic and Linear Peptides — The Sulfhydryl-Specific Linker TPSMB Enables Reversible Cyclization of Peptides" @default.
• W2897467102 cites W1507082667 @default.
• W2897467102 cites W1827782944 @default.
• W2897467102 cites W1964262064 @default.
• W2897467102 cites W1981300064 @default.
• W2897467102 cites W1986184008 @default.
• W2897467102 cites W2016583991 @default.
• W2897467102 cites W2038283518 @default.
• W2897467102 cites W2042061022 @default.
• W2897467102 cites W2049520368 @default.
• W2897467102 cites W2054129051 @default.
• W2897467102 cites W2059937984 @default.
• W2897467102 cites W2065989745 @default.
• W2897467102 cites W2070208631 @default.
• W2897467102 cites W2071135907 @default.
• W2897467102 cites W2073355679 @default.
• W2897467102 cites W2082627580 @default.
• W2897467102 cites W2098164853 @default.
• W2897467102 cites W2109598625 @default.
• W2897467102 cites W2113699453 @default.
• W2897467102 cites W2129842163 @default.
• W2897467102 cites W2133437228 @default.
• W2897467102 cites W2146226667 @default.
• W2897467102 cites W2157327967 @default.
• W2897467102 cites W2165023096 @default.
• W2897467102 cites W2293471056 @default.
• W2897467102 cites W2566366077 @default.
• W2897467102 cites W2594502287 @default.
• W2897467102 cites W2595263958 @default.
• W2897467102 cites W2617816095 @default.
• W2897467102 cites W2738925465 @default.
• W2897467102 cites W2812728820 @default.
• W2897467102 cites W2895074301 @default.
• W2897467102 cites W4230480661 @default.
• W2897467102 doi "https://doi.org/10.3389/fchem.2018.00484" @default.
• W2897467102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6198510" @default.
• W2897467102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30386769" @default.
• W2897467102 hasPublicationYear "2018" @default.
• W2897467102 type Work @default.
• W2897467102 sameAs 2897467102 @default.
• W2897467102 citedByCount "7" @default.
• W2897467102 countsByYear W28974671022021 @default.
• W2897467102 countsByYear W28974671022022 @default.
• W2897467102 countsByYear W28974671022023 @default.
• W2897467102 crossrefType "journal-article" @default.
• W2897467102 hasAuthorship W2897467102A5002907072 @default.
• W2897467102 hasAuthorship W2897467102A5015753523 @default.
• W2897467102 hasAuthorship W2897467102A5022428348 @default.
• W2897467102 hasAuthorship W2897467102A5054574030 @default.
• W2897467102 hasAuthorship W2897467102A5078094651 @default.
• W2897467102 hasAuthorship W2897467102A5086525697 @default.
• W2897467102 hasAuthorship W2897467102A5089643377 @default.
• W2897467102 hasBestOaLocation W28974671021 @default.
• W2897467102 hasConcept C111919701 @default.
• W2897467102 hasConcept C151730666 @default.
• W2897467102 hasConcept C171250308 @default.
• W2897467102 hasConcept C175156509 @default.
• W2897467102 hasConcept C181199279 @default.
• W2897467102 hasConcept C185592680 @default.
• W2897467102 hasConcept C192562407 @default.
• W2897467102 hasConcept C21951064 @default.
• W2897467102 hasConcept C24961977 @default.
• W2897467102 hasConcept C2779201268 @default.
• W2897467102 hasConcept C2779281246 @default.
• W2897467102 hasConcept C2780557392 @default.
• W2897467102 hasConcept C41008148 @default.
• W2897467102 hasConcept C43369102 @default.
• W2897467102 hasConcept C515207424 @default.
• W2897467102 hasConcept C53105671 @default.
• W2897467102 hasConcept C55493867 @default.
• W2897467102 hasConcept C60984968 @default.
• W2897467102 hasConcept C71240020 @default.
• W2897467102 hasConcept C86803240 @default.
• W2897467102 hasConceptScore W2897467102C111919701 @default.
• W2897467102 hasConceptScore W2897467102C151730666 @default.
• W2897467102 hasConceptScore W2897467102C171250308 @default.
• W2897467102 hasConceptScore W2897467102C175156509 @default.
• W2897467102 hasConceptScore W2897467102C181199279 @default.
• W2897467102 hasConceptScore W2897467102C185592680 @default.
• W2897467102 hasConceptScore W2897467102C192562407 @default.
• W2897467102 hasConceptScore W2897467102C21951064 @default.
• W2897467102 hasConceptScore W2897467102C24961977 @default.
• W2897467102 hasConceptScore W2897467102C2779201268 @default.
• W2897467102 hasConceptScore W2897467102C2779281246 @default.
• W2897467102 hasConceptScore W2897467102C2780557392 @default.
• W2897467102 hasConceptScore W2897467102C41008148 @default.
• W2897467102 hasConceptScore W2897467102C43369102 @default.
• W2897467102 hasConceptScore W2897467102C515207424 @default.
• W2897467102 hasConceptScore W2897467102C53105671 @default.

• next