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• W2897468152 endingPage "e429s" @default.
• W2897468152 startingPage "e429s" @default.
• W2897468152 abstract "The immunologic landscape of tumors has been continuously unveiled, providing a new look at the interactions between cancer cells and the immune system. Emerging tumor cells are constantly eliminated by the immune system, but some cells establish a long-term equilibrium phase leading to tumor immunoediting and, eventually, evasion. During this process, tumor cells tend to acquire more mutations. Bearing a high mutation burden leads to a greater number of neoantigens with the potential to initiate an immune response. Although many tumors evoke an immune response, tumor clearance by the immune system does not occur due to a suppressive tumor microenvironment. The mechanisms by which tumors achieve the ability to evade immunologic control vary. Understanding these differences is crucial for the improvement and application of new immune-based therapies. Much effort has been placed in developing in silico algorithms to predict tumor immunogenicity and to characterize the microenvironment via high-throughput sequencing and gene expression techniques. Each sequencing source, transcriptomics, and genomics yields a distinct level of data, helping to elucidate the tumor-based immune responses and guiding the fine-tuning of current and upcoming immune-based therapies. In this review, we explore some of the immunological concepts behind the new immunotherapies and the bioinformatic tools to study the immunological aspects of tumors, focusing on neoantigen determination and microenvironment deconvolution. We further discuss the immune-based therapies already in clinical use, those underway for future clinical application, the next steps in immunotherapy, and how the characterization of the tumor immune contexture can impact therapies aiming to promote or unleash immune-based tumor elimination." @default.
• W2897468152 created "2018-10-26" @default.
• W2897468152 creator A5033717013 @default.
• W2897468152 creator A5036531531 @default.
• W2897468152 creator A5036565811 @default.
• W2897468152 creator A5042140942 @default.
• W2897468152 creator A5047350442 @default.
• W2897468152 creator A5085683117 @default.
• W2897468152 date "2018-01-01" @default.
• W2897468152 modified "2023-09-26" @default.
• W2897468152 title "Immunological-based approaches for cancer therapy" @default.
• W2897468152 cites W1107917109 @default.
• W2897468152 cites W11689126 @default.
• W2897468152 cites W1556687169 @default.
• W2897468152 cites W1607316259 @default.
• W2897468152 cites W1667402130 @default.
• W2897468152 cites W1753684754 @default.
• W2897468152 cites W1838472703 @default.
• W2897468152 cites W1877911682 @default.
• W2897468152 cites W1966542058 @default.
• W2897468152 cites W1967940883 @default.
• W2897468152 cites W1970368422 @default.
• W2897468152 cites W1975589890 @default.
• W2897468152 cites W1985987855 @default.
• W2897468152 cites W1990963334 @default.
• W2897468152 cites W2002132740 @default.
• W2897468152 cites W2009720434 @default.
• W2897468152 cites W2010707643 @default.
• W2897468152 cites W2011458181 @default.
• W2897468152 cites W2011941471 @default.
• W2897468152 cites W2018092044 @default.
• W2897468152 cites W2020228723 @default.
• W2897468152 cites W2020312840 @default.
• W2897468152 cites W2021472146 @default.
• W2897468152 cites W2022495797 @default.
• W2897468152 cites W2044835625 @default.
• W2897468152 cites W2046972425 @default.
• W2897468152 cites W2047433709 @default.
• W2897468152 cites W2049491375 @default.
• W2897468152 cites W2051146169 @default.
• W2897468152 cites W2070748533 @default.
• W2897468152 cites W2076948707 @default.
• W2897468152 cites W2094652659 @default.
• W2897468152 cites W2094945699 @default.
• W2897468152 cites W2096951064 @default.
• W2897468152 cites W2097995306 @default.
• W2897468152 cites W2103959341 @default.
• W2897468152 cites W2104885590 @default.
• W2897468152 cites W2105009956 @default.
• W2897468152 cites W2110641339 @default.
• W2897468152 cites W2112041130 @default.
• W2897468152 cites W2117692326 @default.
• W2897468152 cites W2117884326 @default.
• W2897468152 cites W2118526609 @default.
• W2897468152 cites W2119301589 @default.
• W2897468152 cites W2122465970 @default.
• W2897468152 cites W2127284149 @default.
• W2897468152 cites W2132923173 @default.
• W2897468152 cites W2143772132 @default.
• W2897468152 cites W2148291723 @default.
• W2897468152 cites W2148523692 @default.
• W2897468152 cites W2149452000 @default.
• W2897468152 cites W2150056019 @default.
• W2897468152 cites W2150835657 @default.
• W2897468152 cites W2152061559 @default.
• W2897468152 cites W2158626262 @default.
• W2897468152 cites W2160595349 @default.
• W2897468152 cites W2165320653 @default.
• W2897468152 cites W2166662937 @default.
• W2897468152 cites W2167550136 @default.
• W2897468152 cites W2168091280 @default.
• W2897468152 cites W2170606353 @default.
• W2897468152 cites W2262414037 @default.
• W2897468152 cites W2282550179 @default.
• W2897468152 cites W2291298003 @default.
• W2897468152 cites W2340636398 @default.
• W2897468152 cites W2403289604 @default.
• W2897468152 cites W2404396229 @default.
• W2897468152 cites W2407062242 @default.
• W2897468152 cites W2461410982 @default.
• W2897468152 cites W2467321712 @default.
• W2897468152 cites W2473956396 @default.
• W2897468152 cites W2504729294 @default.
• W2897468152 cites W2508710837 @default.
• W2897468152 cites W2526887159 @default.
• W2897468152 cites W2531592729 @default.
• W2897468152 cites W2536906012 @default.
• W2897468152 cites W2551911481 @default.
• W2897468152 cites W2559513142 @default.
• W2897468152 cites W2559953355 @default.
• W2897468152 cites W2566018578 @default.
• W2897468152 cites W2566775074 @default.
• W2897468152 cites W2569710884 @default.
• W2897468152 cites W2572174216 @default.
• W2897468152 cites W2576658154 @default.
• W2897468152 cites W2588457489 @default.
• W2897468152 cites W2592305500 @default.
• W2897468152 cites W2593147816 @default.

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