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- W2897468948 abstract "We have previously shown that sonoreperfusion (SRP) using ultrasound (US) and microbubble (MB) can restore perfusion following microvascular obstruction and is mediated by nitric oxide vasodilation. Here, we compared the use of short (SP-10 cycles) and long (LP-5000 cycles) pulses for SRP and investigated the vasoactive response time-course and the downstream signaling 4 h post-treatment. In a rat hindlimb, we applied LP or SP (1 MHz,1.5 MPa) with the same number of acoustic cycles for 2 min during MB infusion. Both pulses affected the perfusion rate but with distinct temporal responses. For SP, the flow rate peaked (12.3±3.4 dB/s) at 15 min but returned to baseline (BL)(3.2±0.8 dB/s) after 60 min. Conversely, for LP, the flow rate also initially dropped but started to increase at 6 min and peaked (13.0±2.1 dB/s) at 15 min and was still high (8.3±2.0 dB/s) after 4 h compared to BL and SP. This sustained increase in flow rate, which was different from reactive hyperemia, was concordant with 2.5-fold increases in phosphorylated and total eNOS expression (Western blot) compared to untreated tissue, and consistent with a 2-fold increase in eNOS transcription (qPCR). These data support that long pulse SRP therapy increased in muscle perfusion for at least 4 h consistently with increased eNOS transcription and expression." @default.
- W2897468948 created "2018-10-26" @default.
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- W2897468948 date "2018-09-01" @default.
- W2897468948 modified "2023-09-30" @default.
- W2897468948 title "Time course of the vasoactive response for sonoreperfusion therapy using long tone burst ultrasound" @default.
- W2897468948 doi "https://doi.org/10.1121/1.5067752" @default.
- W2897468948 hasPublicationYear "2018" @default.
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