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- W2897469097 abstract "The loss of cholinergic neurons has been regarded as a major tenet in Alzheimer's disease (AD) research for about 40 years. Therefore, scopolamine-induced memory deficit is being used as an animal model of amnesia. Recently, it is shown that the amnesia of early stages of AD is related to the deficit in retrieval, instead of encoding or consolidation phase. Curcumin, as the main ingredient of turmeric, has been suggested to decrease the prevalence of AD in human population. This study aimed to assess if curcumin prevents retrieval deficit induced by scopolamine in passive avoidance task. Moreover, according to the proposed role of Akt/GSK3β pathway, the hippocampal contents of these proteins were determined. Male NMRI mice (20–25 g body weight) were treated with curcumin 50 or 100 mg/kg/po or its vehicle for 10 days. On day 10, the animals were trained in passive avoidance apparatus. The retention trial was performed 24 hours later. Scopolamine (1 mg/kg/i.p.) or its vehicle was administered 30 min before retention test. At the complement of behavioral studies, the hippocampi were removed and western blot analysis was performed to determine p-Akt, t-Akt, p-GSK3β, t-GSK3β and beta actin contents. The results implied that curcumin treatment in both doses, prevented scopolamine-induced memory retrieval deficit and restored p-Akt and p-GSK decline caused by scopolamine. Considering the recent findings regarding the importance of retrieval phase in early AD, the findings of this study suggest considering curcumin in preventing and curing AD." @default.
- W2897469097 created "2018-10-26" @default.
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- W2897469097 date "2018-07-01" @default.
- W2897469097 modified "2023-10-16" @default.
- W2897469097 title "P3‐038: CURCUMIN PREVENTS SCOPOLAMINE‐INDUCED MEMORY RETRIEVAL DEFICIT IN MICE: CONSIDERING HIPPOCAMPAL AKT/GSK3β SIGNALING" @default.
- W2897469097 doi "https://doi.org/10.1016/j.jalz.2018.06.1393" @default.
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