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- W2897470314 abstract "Abstract Outcome for patients with metastatic or recurrent/refractory osteosarcoma remains poor. Responses to sorafenib, a multikinase inhibitor, have been seen in recurrent/refractory osteosarcoma, although specific biomarkers of response have not been described. We report a partial response in a 7‐year‐old with refractory osteosarcoma treated with sorafenib 200 mg twice daily. Toxicities included Common Terminology Criteria for Adverse Events Grade 2 skin toxicities and growth suppression. After 51 months of therapy, he suffered a recurrence. Tumor sequencing later revealed a PDGFRA D846V mutation that was not identified in the relapse specimen. This case demonstrates prolonged partial response to sorafenib and provides a potential biomarker for response." @default.
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- W2897470314 date "2018-10-14" @default.
- W2897470314 modified "2023-10-01" @default.
- W2897470314 title "Prolonged response to sorafenib in a patient with refractory metastatic osteosarcoma and a somatic <i>PDGFRA</i> D846V mutation" @default.
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- W2897470314 doi "https://doi.org/10.1002/pbc.27493" @default.
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