FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897474496> ?p ?o ?g. }

• W2897474496 endingPage "363" @default.
• W2897474496 startingPage "352" @default.
• W2897474496 abstract "Introduction Glioblastoma multiforme (GBM) is the most common brain malignancy in adults, and currently available GBM treatments present several unique challenges. It is known that GBM involves cancer stem-like cells (CSCs) and tumor cells that aggressively invade normal brain tissues, and both cell types may cause resistance to radiotherapy (RT) and are thus responsible for therapeutic failure. The radioresistance of GBM cells relies on the efficient activation of the DNA damage response (DDR), but the mechanisms linking this response with stem-cell status and tumor invasion remain unclear. Materials and methods We used irradiation to treat patient-derived GBM (Par) cells and then purified radioresistant GBM (R2M2) cells through two rounds of irradiation and an invasion assay. Musashi-1 (MSI1) is a neural stem-cell marker and key oncogenic factor of GBM. We identified MSI1 expression to predict radioresistance through silencing an MSI1-high-expressing R2M2 cell line or inducing overexpression in a Par cell line with low/no MSI1 expression and assessing the subsequent DDR. Result MSI1 enhances tumor invasion via VCAM1 and modulates GBM radioresistance via the hyperactivation of the DDR through increasing homologous recombination repair and evading apoptosis. MSI1 knockdown induces DNA damage accumulation in irradiated GBM cells and promotes their depletion in vitro; MSI1 knockdown also inhibits the formation of GBMs generated by irradiated xeno-transplanted cells. MSI1 inhibition may radiosensitize tumors, prevent CSC-positive selection induced by RT, and reduce tumor invasion. Conclusion MSI1 may involve in regulating GBM radioresistance, invasion, and recurrence and could be a novel target for GBM treatment." @default.
• W2897474496 created "2018-10-26" @default.
• W2897474496 creator A5005769924 @default.
• W2897474496 creator A5010280824 @default.
• W2897474496 creator A5051563313 @default.
• W2897474496 creator A5053586291 @default.
• W2897474496 creator A5055540051 @default.
• W2897474496 creator A5077415743 @default.
• W2897474496 date "2018-11-01" @default.
• W2897474496 modified "2023-09-30" @default.
• W2897474496 title "MSI1 associates glioblastoma radioresistance via homologous recombination repair, tumor invasion and cancer stem-like cell properties" @default.
• W2897474496 cites W1498241449 @default.
• W2897474496 cites W1528342365 @default.
• W2897474496 cites W1584810294 @default.
• W2897474496 cites W1826852120 @default.
• W2897474496 cites W1895091779 @default.
• W2897474496 cites W1926743275 @default.
• W2897474496 cites W1963965802 @default.
• W2897474496 cites W1970018334 @default.
• W2897474496 cites W1978124642 @default.
• W2897474496 cites W1988728114 @default.
• W2897474496 cites W1990006624 @default.
• W2897474496 cites W2007360825 @default.
• W2897474496 cites W2011766094 @default.
• W2897474496 cites W2026972134 @default.
• W2897474496 cites W2040212491 @default.
• W2897474496 cites W2060551076 @default.
• W2897474496 cites W2067632356 @default.
• W2897474496 cites W2071457560 @default.
• W2897474496 cites W2072454733 @default.
• W2897474496 cites W2076951953 @default.
• W2897474496 cites W2096287682 @default.
• W2897474496 cites W2098016561 @default.
• W2897474496 cites W2109102096 @default.
• W2897474496 cites W2112725705 @default.
• W2897474496 cites W2123434257 @default.
• W2897474496 cites W2124482905 @default.
• W2897474496 cites W2149514803 @default.
• W2897474496 cites W2155957543 @default.
• W2897474496 cites W2161289668 @default.
• W2897474496 cites W2205491921 @default.
• W2897474496 cites W2318998587 @default.
• W2897474496 cites W2485667397 @default.
• W2897474496 cites W2584218507 @default.
• W2897474496 cites W2600554604 @default.
• W2897474496 cites W2746487054 @default.
• W2897474496 cites W2791797153 @default.
• W2897474496 doi "https://doi.org/10.1016/j.radonc.2018.09.014" @default.
• W2897474496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30322656" @default.
• W2897474496 hasPublicationYear "2018" @default.
• W2897474496 type Work @default.
• W2897474496 sameAs 2897474496 @default.
• W2897474496 citedByCount "35" @default.
• W2897474496 countsByYear W28974744962018 @default.
• W2897474496 countsByYear W28974744962019 @default.
• W2897474496 countsByYear W28974744962020 @default.
• W2897474496 countsByYear W28974744962021 @default.
• W2897474496 countsByYear W28974744962022 @default.
• W2897474496 countsByYear W28974744962023 @default.
• W2897474496 crossrefType "journal-article" @default.
• W2897474496 hasAuthorship W2897474496A5005769924 @default.
• W2897474496 hasAuthorship W2897474496A5010280824 @default.
• W2897474496 hasAuthorship W2897474496A5051563313 @default.
• W2897474496 hasAuthorship W2897474496A5053586291 @default.
• W2897474496 hasAuthorship W2897474496A5055540051 @default.
• W2897474496 hasAuthorship W2897474496A5077415743 @default.
• W2897474496 hasConcept C143425029 @default.
• W2897474496 hasConcept C173396325 @default.
• W2897474496 hasConcept C28328180 @default.
• W2897474496 hasConcept C502942594 @default.
• W2897474496 hasConcept C54355233 @default.
• W2897474496 hasConcept C552990157 @default.
• W2897474496 hasConcept C55427017 @default.
• W2897474496 hasConcept C58962609 @default.
• W2897474496 hasConcept C81885089 @default.
• W2897474496 hasConcept C86803240 @default.
• W2897474496 hasConcept C95444343 @default.
• W2897474496 hasConceptScore W2897474496C143425029 @default.
• W2897474496 hasConceptScore W2897474496C173396325 @default.
• W2897474496 hasConceptScore W2897474496C28328180 @default.
• W2897474496 hasConceptScore W2897474496C502942594 @default.
• W2897474496 hasConceptScore W2897474496C54355233 @default.
• W2897474496 hasConceptScore W2897474496C552990157 @default.
• W2897474496 hasConceptScore W2897474496C55427017 @default.
• W2897474496 hasConceptScore W2897474496C58962609 @default.
• W2897474496 hasConceptScore W2897474496C81885089 @default.
• W2897474496 hasConceptScore W2897474496C86803240 @default.
• W2897474496 hasConceptScore W2897474496C95444343 @default.
• W2897474496 hasIssue "2" @default.
• W2897474496 hasLocation W28974744961 @default.
• W2897474496 hasLocation W28974744962 @default.
• W2897474496 hasOpenAccess W2897474496 @default.
• W2897474496 hasPrimaryLocation W28974744961 @default.
• W2897474496 hasRelatedWork W178543369 @default.
• W2897474496 hasRelatedWork W1997203401 @default.
• W2897474496 hasRelatedWork W2506227723 @default.
• W2897474496 hasRelatedWork W2564226876 @default.
• W2897474496 hasRelatedWork W2808532349 @default.

• next