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- W2897475413 endingPage "493" @default.
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- W2897475413 abstract "The ability of neurites of individual neurons to distinguish between themselves and neurites from other neurons and to avoid self (self-avoidance) plays a key role in neural circuit assembly in both invertebrates and vertebrates. Similarly, when individual neurons of the same type project into receptive fields of the brain, they must avoid each other to maximize target coverage (tiling). Counterintuitively, these processes are driven by highly specific homophilic interactions between cell surface proteins that lead to neurite repulsion rather than adhesion. Among these proteins in vertebrates are the clustered protocadherins (Pcdhs), and key to their function is the generation of enormous cell surface structural diversity. Here we review recent advances in understanding how a Pcdh cell surface code is generated by stochastic promoter choice; how this code is amplified and read by homophilic interactions between Pcdh complexes at the surface of neurons; and, finally, how the Pcdh code is translated to cellular function, which mediates self-avoidance and tiling and thus plays a central role in the development of complex neural circuits. Not surprisingly, Pcdh mutations that diminish homophilic interactions lead to wiring defects and abnormal behavior in mice, and sequence variants in the Pcdh gene cluster are associated with autism spectrum disorders in family-based genetic studies in humans." @default.
- W2897475413 created "2018-10-26" @default.
- W2897475413 creator A5052916249 @default.
- W2897475413 creator A5063168240 @default.
- W2897475413 creator A5067230615 @default.
- W2897475413 creator A5080524672 @default.
- W2897475413 creator A5091116725 @default.
- W2897475413 date "2018-10-06" @default.
- W2897475413 modified "2023-10-17" @default.
- W2897475413 title "Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly" @default.
- W2897475413 cites W133424498 @default.
- W2897475413 cites W1481885984 @default.
- W2897475413 cites W1548344655 @default.
- W2897475413 cites W1828538530 @default.
- W2897475413 cites W1902978248 @default.
- W2897475413 cites W1941076503 @default.
- W2897475413 cites W1972985327 @default.
- W2897475413 cites W1973062929 @default.
- W2897475413 cites W1974594271 @default.
- W2897475413 cites W1974637131 @default.
- W2897475413 cites W1977559278 @default.
- W2897475413 cites W1983845889 @default.
- W2897475413 cites W1985445026 @default.
- W2897475413 cites W1987429832 @default.
- W2897475413 cites W1987449934 @default.
- W2897475413 cites W1988276587 @default.
- W2897475413 cites W1988394934 @default.
- W2897475413 cites W1990545433 @default.
- W2897475413 cites W2005611301 @default.
- W2897475413 cites W2007981920 @default.
- W2897475413 cites W2013934108 @default.
- W2897475413 cites W2014327040 @default.
- W2897475413 cites W2018210971 @default.
- W2897475413 cites W2018979418 @default.
- W2897475413 cites W2020869819 @default.
- W2897475413 cites W2026754734 @default.
- W2897475413 cites W2028807389 @default.
- W2897475413 cites W2030292651 @default.
- W2897475413 cites W2031627559 @default.
- W2897475413 cites W2038587881 @default.
- W2897475413 cites W2042531021 @default.
- W2897475413 cites W2046466208 @default.
- W2897475413 cites W2047969260 @default.
- W2897475413 cites W2049862483 @default.
- W2897475413 cites W2051036306 @default.
- W2897475413 cites W2060876619 @default.
- W2897475413 cites W2068391384 @default.
- W2897475413 cites W2069186336 @default.
- W2897475413 cites W2069638671 @default.
- W2897475413 cites W2070372326 @default.
- W2897475413 cites W2071759249 @default.
- W2897475413 cites W2077096793 @default.
- W2897475413 cites W2080141091 @default.
- W2897475413 cites W2081237481 @default.
- W2897475413 cites W2081451150 @default.
- W2897475413 cites W2084805548 @default.
- W2897475413 cites W2089483026 @default.
- W2897475413 cites W2095280927 @default.
- W2897475413 cites W2110233724 @default.
- W2897475413 cites W2120369399 @default.
- W2897475413 cites W2121508096 @default.
- W2897475413 cites W2126335768 @default.
- W2897475413 cites W2128891183 @default.
- W2897475413 cites W2130988208 @default.
- W2897475413 cites W2132637814 @default.
- W2897475413 cites W2134861134 @default.
- W2897475413 cites W2135190897 @default.
- W2897475413 cites W2138508631 @default.
- W2897475413 cites W2149542788 @default.
- W2897475413 cites W2150822416 @default.
- W2897475413 cites W2152438166 @default.
- W2897475413 cites W2152970852 @default.
- W2897475413 cites W2154612705 @default.
- W2897475413 cites W2155899899 @default.
- W2897475413 cites W2156561767 @default.
- W2897475413 cites W2158766243 @default.
- W2897475413 cites W2168153190 @default.
- W2897475413 cites W2169550012 @default.
- W2897475413 cites W2170170033 @default.
- W2897475413 cites W2345554661 @default.
- W2897475413 cites W2401478493 @default.
- W2897475413 cites W2460062293 @default.
- W2897475413 cites W2475437687 @default.
- W2897475413 cites W2544114634 @default.
- W2897475413 cites W2558207675 @default.
- W2897475413 cites W2566188612 @default.
- W2897475413 cites W2608960550 @default.
- W2897475413 cites W2609239411 @default.
- W2897475413 cites W2609422947 @default.
- W2897475413 cites W2610554832 @default.
- W2897475413 cites W2620884102 @default.
- W2897475413 cites W2621892125 @default.
- W2897475413 cites W2652717092 @default.
- W2897475413 cites W2724956132 @default.
- W2897475413 cites W2731637345 @default.
- W2897475413 cites W2737936840 @default.
- W2897475413 cites W2740051188 @default.
- W2897475413 cites W2741629554 @default.