FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897478545> ?p ?o ?g. }

• W2897478545 abstract "Cerebral small vessel disease (SVD) frequently coexists with amyloid pathology in Alzheimer's disease (AD), and these pathological processes may interact. White matter (WM) lesions are hallmarks of SVD. They are usually assessed by WM hyperintensities on T2-weighted MRI images, but WM hypointensities on T1-weighted images may be an equally good measure of SVD. The aim of this study was to explore whether WM hypointensity volumes (WMHo) are related to AD predementia markers and APOE. Cases and controls, aged 40-80, were included from the DDI longitudinal multi-site study (n=343, age=63.1, m/f=157/186). Participants underwent clinical and cognitive assessment (n=339), MRI (n=343), APOE genotyping (n=326) and lumbar puncture (n=307). Cases were staged as Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI), and further stratified by Ab1-42 pathology (Ab+/-), using an amyloid-PET verified CSF cutoff. Cognitively normal Ab- controls were classified as Healthy Controls (HC). APOE-e4 carriers were defined as APOEe4 positive (APOEe4+). WMHo was determined using FreeSurfer. Partial correlation analysis was done between WMHo (normalized against intracranial volume) and CSF Ab, stratified by APOE status. The interaction between WMHo and APOE (on CSF Ab) was tested in a linear regression model. WMHo was log-transformed and compared between groups by linear regression. All analyses were adjusted for age. There was a significant correlation between WMHo and CSF Ab in APOEe4+ subjects (n=134) (r=-0.28, p=0.001), but not in APOEe4- subjects (n=164) or the overall cohort (n=307). The interaction between WMHo and APOE was significant (n=289, p<0.001). The SCD-Ab+ group (n=19) had significantly higher WMHo than SCD-Ab- (n=105) (p=0.042) and HC (n=56) (p=0.026), and also the MCI-Ab+ group (n=41) had significantly higher WMHo than MCI-Ab- (n=66) (p=0.017) and HC (p=0.004). There was no significant difference between the Ab+ SCD and MCI groups. SCD-Ab+ cases had higher levels of WMHo than both healthy controls and SCD-Ab-. There was a correlation between WMHo and CSF Ab levels in APOEe4+, and a significant interaction between WMHo and APOE on CSF Ab levels. These findings indicate an interplay between APOE-e4 and SVD, and further implicate SVD as a feature of early predementia AD." @default.
• W2897478545 created "2018-10-26" @default.
• W2897478545 creator A5003186243 @default.
• W2897478545 creator A5063053273 @default.
• W2897478545 creator A5067222135 @default.
• W2897478545 creator A5088290771 @default.
• W2897478545 date "2018-07-01" @default.
• W2897478545 modified "2023-10-18" @default.
• W2897478545 title "P3‐358: WHITE MATTER PATHOLOGY INTERACTS WITH APOE AND IS INCREASED IN AMYLOID‐POSITIVE SUBJECTIVE COGNITIVE DECLINE" @default.
• W2897478545 doi "https://doi.org/10.1016/j.jalz.2018.06.1720" @default.
• W2897478545 hasPublicationYear "2018" @default.
• W2897478545 type Work @default.
• W2897478545 sameAs 2897478545 @default.
• W2897478545 citedByCount "0" @default.
• W2897478545 crossrefType "journal-article" @default.
• W2897478545 hasAuthorship W2897478545A5003186243 @default.
• W2897478545 hasAuthorship W2897478545A5063053273 @default.
• W2897478545 hasAuthorship W2897478545A5067222135 @default.
• W2897478545 hasAuthorship W2897478545A5088290771 @default.
• W2897478545 hasConcept C126322002 @default.
• W2897478545 hasConcept C126838900 @default.
• W2897478545 hasConcept C142724271 @default.
• W2897478545 hasConcept C143409427 @default.
• W2897478545 hasConcept C146638467 @default.
• W2897478545 hasConcept C15744967 @default.
• W2897478545 hasConcept C2777633098 @default.
• W2897478545 hasConcept C2779134260 @default.
• W2897478545 hasConcept C2779483572 @default.
• W2897478545 hasConcept C2781073650 @default.
• W2897478545 hasConcept C2781192897 @default.
• W2897478545 hasConcept C2984863031 @default.
• W2897478545 hasConcept C2984915365 @default.
• W2897478545 hasConcept C57089818 @default.
• W2897478545 hasConcept C71924100 @default.
• W2897478545 hasConceptScore W2897478545C126322002 @default.
• W2897478545 hasConceptScore W2897478545C126838900 @default.
• W2897478545 hasConceptScore W2897478545C142724271 @default.
• W2897478545 hasConceptScore W2897478545C143409427 @default.
• W2897478545 hasConceptScore W2897478545C146638467 @default.
• W2897478545 hasConceptScore W2897478545C15744967 @default.
• W2897478545 hasConceptScore W2897478545C2777633098 @default.
• W2897478545 hasConceptScore W2897478545C2779134260 @default.
• W2897478545 hasConceptScore W2897478545C2779483572 @default.
• W2897478545 hasConceptScore W2897478545C2781073650 @default.
• W2897478545 hasConceptScore W2897478545C2781192897 @default.
• W2897478545 hasConceptScore W2897478545C2984863031 @default.
• W2897478545 hasConceptScore W2897478545C2984915365 @default.
• W2897478545 hasConceptScore W2897478545C57089818 @default.
• W2897478545 hasConceptScore W2897478545C71924100 @default.
• W2897478545 hasIssue "7S_Part_23" @default.
• W2897478545 hasLocation W28974785451 @default.
• W2897478545 hasOpenAccess W2897478545 @default.
• W2897478545 hasPrimaryLocation W28974785451 @default.
• W2897478545 hasRelatedWork W1993468227 @default.
• W2897478545 hasRelatedWork W2023905125 @default.
• W2897478545 hasRelatedWork W2030227264 @default.
• W2897478545 hasRelatedWork W2045661260 @default.
• W2897478545 hasRelatedWork W2587855890 @default.
• W2897478545 hasRelatedWork W2791785058 @default.
• W2897478545 hasRelatedWork W2978765218 @default.
• W2897478545 hasRelatedWork W3118999301 @default.
• W2897478545 hasRelatedWork W4297023916 @default.
• W2897478545 hasRelatedWork W2781545721 @default.
• W2897478545 hasVolume "14" @default.
• W2897478545 isParatext "false" @default.
• W2897478545 isRetracted "false" @default.
• W2897478545 magId "2897478545" @default.
• W2897478545 workType "article" @default.