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- W2897499581 abstract "Abstract Following the rise of prokaryote life dependent on anaerobic respiration, oxygen was produced as a toxic by-product. This steadily and significantly contributed to the formation of an oxygen-rich environment that resulted in a shift in atmospheric and oceanic redox status. This necessitated the evolution of aerobic respiration, and mitochondria seemingly arose independently of bacterial life before becoming incorporated into eukaryote cells. Aerobic respiration allowed for a significant increase in adenosine triphosphate production, which is critical to meet the energy demands required for complex multicellular life to evolve. This molecular process also results in a leakage of potentially toxic reactive oxygen species (ROS) from the mitochondria. Although ROS have evolved as critical molecular and cellular regulators, excessive ROS damages cellular molecules and components. Therefore, endogenous antioxidants evolved as an important regulator of the redox state within the cellular environment in order to optimize the beneficial roles of redox biology." @default.
- W2897499581 created "2018-10-26" @default.
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- W2897499581 date "2019-01-01" @default.
- W2897499581 modified "2023-09-26" @default.
- W2897499581 title "Life Under Aerobic Conditions" @default.
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- W2897499581 doi "https://doi.org/10.1016/b978-0-12-812501-4.00001-8" @default.
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