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• W2897499995 abstract "<h3>Objective</h3> To study if parental subfertility is related to the occurrence of the male genital anomalies, cryptorchidism and hypospadias. <h3>Design</h3> Population-based cohort study. <h3>Setting</h3> Not applicable. <h3>Patient(s)</h3> A total of 80,220 singleton boys and their mothers from the Danish National Birth Cohort and the Aarhus Birth Cohort. <h3>Intervention(s)</h3> None. <h3>Main Outcome Measure(s)</h3> The two congenital anomalies; cryptorchidism and hypospadias, registered within the Danish National Patient Register up until December 31, 2012. <h3>Result(s)</h3> By means of Cox regression analyses, we found no associations between waiting time-to-pregnancy (TTP) and cryptorchidism or hypospadias among those who conceived spontaneously. The highest hazard ratio for cryptorchidism was seen among boys of couples with a TTP>12 months who conceived after fertility treatment (adjusted hazard ratio [aHR] 1.19, 95% confidence interval 0.92–1.55). For hypospadias, we found that boys of couples with a TTP>12 months who conceived after fertility treatment, had a 71% higher risk of hypospadias (aHR 1.71, [95% confidence interval 1.24–3.36]) as compared with boys of couples with a TTP<5 months. <h3>Conclusion(s)</h3> The findings from this study showed that boys of couples with TTP>12 months who conceived after fertility treatment, had a higher occurrence of hypospadias than boys conceived spontaneously of couples with a short TTP. Among those who conceived spontaneously, TTP was not associated with hypospadias or cryptorchidism. These findings indicate that fertility treatment or severity of subfertility is related to hypospadias." @default.
• W2897499995 created "2018-10-26" @default.
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• W2897499995 date "2018-10-01" @default.
• W2897499995 modified "2023-09-26" @default.
• W2897499995 title "Parental subfertility and hypospadias and cryptorchidism in boys: results from two Danish birth cohorts" @default.
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• W2897499995 doi "https://doi.org/10.1016/j.fertnstert.2018.06.010" @default.
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