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- W2897504554 abstract "Systems biology uses a combination of experimental and mathematical approaches to investigate the complex and dynamic interactions with a given system or biological process. Systems biology integrates genetics, signal transduction, biochemistry and cell biology with mathematical modeling. It can be used to identify novel pathways implicated in diseases as well as to understand the mechanisms by which a specific gene is regulated. This review describes the development of mathematical models for the regulation of an endogenous modifier gene, SMN2, in spinal muscular atrophy-an early-onset motor neuron disease that is a leading genetic cause of infant mortality worldwide-by cAMP signaling. These mathematical models not only can aid in understanding how SMN2 expression is regulated but they can also be used to examine the best ways to manipulate cAMP signaling to maximally increase SMN2 expression. These models will lead to the development of therapeutic strategies for treating SMA. This systems biology approach can also be applied to other neurological diseases, particularly those in which a disease-causing gene or a modifier gene has been identified." @default.
- W2897504554 created "2018-10-26" @default.
- W2897504554 creator A5028163347 @default.
- W2897504554 date "2018-01-01" @default.
- W2897504554 modified "2023-09-26" @default.
- W2897504554 title "Using Systems Biology and Mathematical Modeling Approaches in the Discovery of Therapeutic Targets for Spinal Muscular Atrophy" @default.
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- W2897504554 cites W1964967925 @default.
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- W2897504554 cites W1977055260 @default.
- W2897504554 cites W1980477780 @default.
- W2897504554 cites W1988447677 @default.
- W2897504554 cites W2002575873 @default.
- W2897504554 cites W2003003919 @default.
- W2897504554 cites W2007954199 @default.
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- W2897504554 cites W2017970712 @default.
- W2897504554 cites W2019264851 @default.
- W2897504554 cites W2025927109 @default.
- W2897504554 cites W2028861985 @default.
- W2897504554 cites W2030617701 @default.
- W2897504554 cites W2033377350 @default.
- W2897504554 cites W2033608839 @default.
- W2897504554 cites W2034435537 @default.
- W2897504554 cites W2035461158 @default.
- W2897504554 cites W2043418934 @default.
- W2897504554 cites W2049842485 @default.
- W2897504554 cites W2052097013 @default.
- W2897504554 cites W2054380003 @default.
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- W2897504554 cites W2146223217 @default.
- W2897504554 cites W2148536601 @default.
- W2897504554 cites W2150908245 @default.
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- W2897504554 doi "https://doi.org/10.1007/978-3-319-94593-4_10" @default.
- W2897504554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6482380" @default.
- W2897504554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30334226" @default.
- W2897504554 hasPublicationYear "2018" @default.
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