Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897506738> ?p ?o ?g. }
- W2897506738 endingPage "1031" @default.
- W2897506738 startingPage "1021" @default.
- W2897506738 abstract "Xanthigen® is a nutraceutical combination for weight management capable of increasing energy expenditure via uncoupling protein 1 (UCP-1) in white adipose tissue. It consists of brown seaweed Undaria pinnatifida extract, rich in the carotenoid fucoxanthin (FX) and pomegranate seed oil (PSO), rich in punicic acid. Xanthigen was screened to determine its genotoxicity and 90-days repeated oral toxicity. Genotoxicity was assessed with the Ames test (TA89, TA100, TA1535, TA1537, WP2), chromosomal aberration assay (Chinese hamster ovary cells) and mammalian micronucleus test (in mice). Xanthigen did not exhibit genotoxicity in any tested strain. Sub-chronic toxicity was evaluated with daily oral administration of 250, 500 and 1000 mg/kg/day doses of Xanthigen® to Sprague-Dawley rats over 90 days. No deaths and no deleterious effects were observed during the 90-day treatment, indicating an absence of sub-chronic toxicity and a no observed adverse effect level greater than 1000 mg/kg/day. A statistically significant decrease in bodyweight and food intake in Xanthigen® treated groups was attributed to the weight loss property of Xanthigen®. Overall, Xanthigen® shows no significant mutagenic or toxic effects." @default.
- W2897506738 created "2018-10-26" @default.
- W2897506738 creator A5006318724 @default.
- W2897506738 creator A5018962575 @default.
- W2897506738 creator A5019235396 @default.
- W2897506738 creator A5029890519 @default.
- W2897506738 creator A5036144770 @default.
- W2897506738 creator A5077457641 @default.
- W2897506738 creator A5078837157 @default.
- W2897506738 date "2018-01-01" @default.
- W2897506738 modified "2023-10-16" @default.
- W2897506738 title "Toxicological assessment of Xanthigen® nutraceutical extract combination: Mutagenicity, genotoxicity and oral toxicity" @default.
- W2897506738 cites W1617248832 @default.
- W2897506738 cites W1968016794 @default.
- W2897506738 cites W1970187819 @default.
- W2897506738 cites W1978599577 @default.
- W2897506738 cites W1983200739 @default.
- W2897506738 cites W1983741471 @default.
- W2897506738 cites W2004627855 @default.
- W2897506738 cites W2005156172 @default.
- W2897506738 cites W2014076063 @default.
- W2897506738 cites W2016141715 @default.
- W2897506738 cites W2019044164 @default.
- W2897506738 cites W2019508567 @default.
- W2897506738 cites W2025539784 @default.
- W2897506738 cites W2065838752 @default.
- W2897506738 cites W2071709963 @default.
- W2897506738 cites W2095295874 @default.
- W2897506738 cites W2105435654 @default.
- W2897506738 cites W2107873337 @default.
- W2897506738 cites W2153678718 @default.
- W2897506738 cites W2164271483 @default.
- W2897506738 doi "https://doi.org/10.1016/j.toxrep.2018.10.007" @default.
- W2897506738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205089" @default.
- W2897506738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30386730" @default.
- W2897506738 hasPublicationYear "2018" @default.
- W2897506738 type Work @default.
- W2897506738 sameAs 2897506738 @default.
- W2897506738 citedByCount "7" @default.
- W2897506738 countsByYear W28975067382020 @default.
- W2897506738 countsByYear W28975067382021 @default.
- W2897506738 countsByYear W28975067382022 @default.
- W2897506738 countsByYear W28975067382023 @default.
- W2897506738 crossrefType "journal-article" @default.
- W2897506738 hasAuthorship W2897506738A5006318724 @default.
- W2897506738 hasAuthorship W2897506738A5018962575 @default.
- W2897506738 hasAuthorship W2897506738A5019235396 @default.
- W2897506738 hasAuthorship W2897506738A5029890519 @default.
- W2897506738 hasAuthorship W2897506738A5036144770 @default.
- W2897506738 hasAuthorship W2897506738A5077457641 @default.
- W2897506738 hasAuthorship W2897506738A5078837157 @default.
- W2897506738 hasBestOaLocation W28975067381 @default.
- W2897506738 hasConcept C116263406 @default.
- W2897506738 hasConcept C117632636 @default.
- W2897506738 hasConcept C17857428 @default.
- W2897506738 hasConcept C178790620 @default.
- W2897506738 hasConcept C185592680 @default.
- W2897506738 hasConcept C2777495288 @default.
- W2897506738 hasConcept C2778959862 @default.
- W2897506738 hasConcept C2781065037 @default.
- W2897506738 hasConcept C29730261 @default.
- W2897506738 hasConcept C31903555 @default.
- W2897506738 hasConcept C36681516 @default.
- W2897506738 hasConcept C45080847 @default.
- W2897506738 hasConcept C523546767 @default.
- W2897506738 hasConcept C54355233 @default.
- W2897506738 hasConcept C556039675 @default.
- W2897506738 hasConcept C71924100 @default.
- W2897506738 hasConcept C86803240 @default.
- W2897506738 hasConcept C98274493 @default.
- W2897506738 hasConceptScore W2897506738C116263406 @default.
- W2897506738 hasConceptScore W2897506738C117632636 @default.
- W2897506738 hasConceptScore W2897506738C17857428 @default.
- W2897506738 hasConceptScore W2897506738C178790620 @default.
- W2897506738 hasConceptScore W2897506738C185592680 @default.
- W2897506738 hasConceptScore W2897506738C2777495288 @default.
- W2897506738 hasConceptScore W2897506738C2778959862 @default.
- W2897506738 hasConceptScore W2897506738C2781065037 @default.
- W2897506738 hasConceptScore W2897506738C29730261 @default.
- W2897506738 hasConceptScore W2897506738C31903555 @default.
- W2897506738 hasConceptScore W2897506738C36681516 @default.
- W2897506738 hasConceptScore W2897506738C45080847 @default.
- W2897506738 hasConceptScore W2897506738C523546767 @default.
- W2897506738 hasConceptScore W2897506738C54355233 @default.
- W2897506738 hasConceptScore W2897506738C556039675 @default.
- W2897506738 hasConceptScore W2897506738C71924100 @default.
- W2897506738 hasConceptScore W2897506738C86803240 @default.
- W2897506738 hasConceptScore W2897506738C98274493 @default.
- W2897506738 hasLocation W28975067381 @default.
- W2897506738 hasLocation W28975067382 @default.
- W2897506738 hasLocation W28975067383 @default.
- W2897506738 hasLocation W28975067384 @default.
- W2897506738 hasOpenAccess W2897506738 @default.
- W2897506738 hasPrimaryLocation W28975067381 @default.
- W2897506738 hasRelatedWork W1968307214 @default.
- W2897506738 hasRelatedWork W1985179162 @default.
- W2897506738 hasRelatedWork W2091355127 @default.
- W2897506738 hasRelatedWork W2372154263 @default.