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• W2897511701 endingPage "e1007061" @default.
• W2897511701 startingPage "e1007061" @default.
• W2897511701 abstract "Genetic interactions, a phenomenon whereby combinations of mutations lead to unexpected effects, reflect how cellular processes are wired and play an important role in complex genetic diseases. Understanding the molecular basis of genetic interactions is crucial for deciphering pathway organization as well as understanding the relationship between genetic variation and disease. Several hypothetical molecular mechanisms have been linked to different genetic interaction types. However, differences in genetic interaction patterns and their underlying mechanisms have not yet been compared systematically between different functional gene classes. Here, differences in the occurrence and types of genetic interactions are compared for two classes, gene-specific transcription factors (GSTFs) and signaling genes (kinases and phosphatases). Genome-wide gene expression data for 63 single and double deletion mutants in baker’s yeast reveals that the two most common genetic interaction patterns are buffering and inversion. Buffering is typically associated with redundancy and is well understood. In inversion, genes show opposite behavior in the double mutant compared to the corresponding single mutants. The underlying mechanism is poorly understood. Although both classes show buffering and inversion patterns, the prevalence of inversion is much stronger in GSTFs. To decipher potential mechanisms, a Petri Net modeling approach was employed, where genes are represented as nodes and relationships between genes as edges. This allowed over 9 million possible three and four node models to be exhaustively enumerated. The models show that a quantitative difference in interaction strength is a strict requirement for obtaining inversion. In addition, this difference is frequently accompanied with a second gene that shows buffering. Taken together, these results provide a mechanistic explanation for inversion. Furthermore, the ability of transcription factors to differentially regulate expression of their targets provides a likely explanation why inversion is more prevalent for GSTFs compared to kinases and phosphatases." @default.
• W2897511701 created "2018-10-26" @default.
• W2897511701 creator A5004123617 @default.
• W2897511701 creator A5030871402 @default.
• W2897511701 creator A5041175377 @default.
• W2897511701 creator A5046800431 @default.
• W2897511701 creator A5050497238 @default.
• W2897511701 creator A5054615637 @default.
• W2897511701 creator A5072491065 @default.
• W2897511701 creator A5072764147 @default.
• W2897511701 date "2019-05-13" @default.
• W2897511701 modified "2023-10-16" @default.
• W2897511701 title "The ability of transcription factors to differentially regulate gene expression is a crucial component of the mechanism underlying inversion, a frequently observed genetic interaction pattern" @default.
• W2897511701 cites W1548851567 @default.
• W2897511701 cites W1644724366 @default.
• W2897511701 cites W1842777387 @default.
• W2897511701 cites W1935948820 @default.
• W2897511701 cites W1966902958 @default.
• W2897511701 cites W1969101463 @default.
• W2897511701 cites W1971299565 @default.
• W2897511701 cites W1972946410 @default.
• W2897511701 cites W1975931018 @default.
• W2897511701 cites W1985432682 @default.
• W2897511701 cites W1986397618 @default.
• W2897511701 cites W1986628548 @default.
• W2897511701 cites W1988263223 @default.
• W2897511701 cites W1990072661 @default.
• W2897511701 cites W1993099483 @default.
• W2897511701 cites W1994267372 @default.
• W2897511701 cites W1996973085 @default.
• W2897511701 cites W2005528479 @default.
• W2897511701 cites W2008854410 @default.
• W2897511701 cites W2013970469 @default.
• W2897511701 cites W2020122212 @default.
• W2897511701 cites W2023003671 @default.
• W2897511701 cites W2025085818 @default.
• W2897511701 cites W2029346055 @default.
• W2897511701 cites W2036503152 @default.
• W2897511701 cites W2037878200 @default.
• W2897511701 cites W2039053938 @default.
• W2897511701 cites W2041834021 @default.
• W2897511701 cites W2047254504 @default.
• W2897511701 cites W2050381317 @default.
• W2897511701 cites W2052815101 @default.
• W2897511701 cites W2053961182 @default.
• W2897511701 cites W2060130700 @default.
• W2897511701 cites W2061004320 @default.
• W2897511701 cites W2062029454 @default.
• W2897511701 cites W2062185406 @default.
• W2897511701 cites W2062699991 @default.
• W2897511701 cites W2065398669 @default.
• W2897511701 cites W2068268311 @default.
• W2897511701 cites W2072411792 @default.
• W2897511701 cites W2094082493 @default.
• W2897511701 cites W2094189284 @default.
• W2897511701 cites W2097390727 @default.
• W2897511701 cites W2099329054 @default.
• W2897511701 cites W2101762601 @default.
• W2897511701 cites W2102247469 @default.
• W2897511701 cites W2106170424 @default.
• W2897511701 cites W2107022906 @default.
• W2897511701 cites W2107194761 @default.
• W2897511701 cites W2107233900 @default.
• W2897511701 cites W2111123076 @default.
• W2897511701 cites W2112441403 @default.
• W2897511701 cites W2114853315 @default.
• W2897511701 cites W2115955060 @default.
• W2897511701 cites W2124721555 @default.
• W2897511701 cites W2124821411 @default.
• W2897511701 cites W2126886104 @default.
• W2897511701 cites W2130139983 @default.
• W2897511701 cites W2130856032 @default.
• W2897511701 cites W2133569473 @default.
• W2897511701 cites W2133809942 @default.
• W2897511701 cites W2136795545 @default.
• W2897511701 cites W2138470019 @default.
• W2897511701 cites W2140373545 @default.
• W2897511701 cites W2143416571 @default.
• W2897511701 cites W2143952372 @default.
• W2897511701 cites W2150749732 @default.
• W2897511701 cites W2153134824 @default.
• W2897511701 cites W2158004934 @default.
• W2897511701 cites W2159460045 @default.
• W2897511701 cites W2160849328 @default.
• W2897511701 cites W2165853773 @default.
• W2897511701 cites W2167398354 @default.
• W2897511701 cites W2169927110 @default.
• W2897511701 cites W2183788376 @default.
• W2897511701 cites W2188594044 @default.
• W2897511701 cites W2205662772 @default.
• W2897511701 cites W2301895586 @default.
• W2897511701 cites W2346018449 @default.
• W2897511701 cites W2402275317 @default.
• W2897511701 cites W2522417827 @default.
• W2897511701 cites W2561754210 @default.
• W2897511701 cites W2562947047 @default.
• W2897511701 cites W2592738355 @default.
• W2897511701 cites W2597646117 @default.

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