FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897517162> ?p ?o ?g. }

• W2897517162 abstract "Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. LIN28 homolog A (LIN28A) is a RNA‑binding protein, which serves a fundamental role in cell development and pluripotency. Polo‑like kinase 4 (PLK4) is a member of the polo‑like kinase family, which primarily takes part in the mitotic regulation. Overexpression of LIN28A has been demonstrated in ovarian cancer; however, the expression of PLK4 and the correlation between the expression of LIN28A and PLK4 in EOC has not been discussed. In the present study, the mRNA and protein levels of LIN28A and PLK4 were evaluated by reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry in ovarian tissues of patients. Results demonstrated significantly increased expression in EOC compared with benign epithelial ovarian tumors. High expression of LIN28A and PLK4 was detected at the advanced pathological stage. Furthermore, PLK4 expression was positively correlated with LIN28A (r=0.555; P=0.039). The median survival analysis of patients with EOC with LIN28A and PLK4 double positive expression was 14 months, compared with 30 months in single positive and 60 months in double negative patients by Kaplan‑Meier analysis (P<0.05). The expressions of LIN28A and PLK4 was elevated in different EOC cell lines compared to with a normal ovarian cell line. The 293T cells transfected with LIN28A plus a PLK4 plasmid were the fastest‑growing group. These results suggest that co‑expression of LIN28A and PLK4 may be associated with poor prognosis of EOC and could serve as promising prognostic biomarkers and therapeutic targets in EOC. LIN28A and PLK4 may be used along with traditional morphological and clinical characteristics for predicting prognosis." @default.
• W2897517162 created "2018-10-26" @default.
• W2897517162 creator A5004144742 @default.
• W2897517162 creator A5005082513 @default.
• W2897517162 creator A5008484454 @default.
• W2897517162 creator A5008827800 @default.
• W2897517162 creator A5023461224 @default.
• W2897517162 creator A5027467135 @default.
• W2897517162 creator A5028287056 @default.
• W2897517162 creator A5036233323 @default.
• W2897517162 creator A5039896971 @default.
• W2897517162 creator A5048807755 @default.
• W2897517162 creator A5054439790 @default.
• W2897517162 creator A5069035178 @default.
• W2897517162 creator A5070633210 @default.
• W2897517162 date "2018-10-16" @default.
• W2897517162 modified "2023-10-02" @default.
• W2897517162 title "High LIN28A and PLK4 co‑expression is associated with poor prognosis in epithelial ovarian cancer" @default.
• W2897517162 cites W1853854707 @default.
• W2897517162 cites W1907953875 @default.
• W2897517162 cites W1967533656 @default.
• W2897517162 cites W1968438075 @default.
• W2897517162 cites W1968952077 @default.
• W2897517162 cites W1974756790 @default.
• W2897517162 cites W1977838702 @default.
• W2897517162 cites W1983504654 @default.
• W2897517162 cites W1987198984 @default.
• W2897517162 cites W1997391502 @default.
• W2897517162 cites W2000302922 @default.
• W2897517162 cites W2019167811 @default.
• W2897517162 cites W2027336843 @default.
• W2897517162 cites W2027748580 @default.
• W2897517162 cites W2029150071 @default.
• W2897517162 cites W2037139254 @default.
• W2897517162 cites W2054288757 @default.
• W2897517162 cites W2059706140 @default.
• W2897517162 cites W2062219923 @default.
• W2897517162 cites W2074897052 @default.
• W2897517162 cites W2091031404 @default.
• W2897517162 cites W2106391705 @default.
• W2897517162 cites W2107277218 @default.
• W2897517162 cites W2111366125 @default.
• W2897517162 cites W2118437944 @default.
• W2897517162 cites W2133464976 @default.
• W2897517162 cites W2139706862 @default.
• W2897517162 cites W2140307399 @default.
• W2897517162 cites W2144448977 @default.
• W2897517162 cites W2151628822 @default.
• W2897517162 cites W2159252302 @default.
• W2897517162 cites W2165093450 @default.
• W2897517162 cites W2203521782 @default.
• W2897517162 cites W2235393999 @default.
• W2897517162 cites W2253467674 @default.
• W2897517162 cites W2266765267 @default.
• W2897517162 cites W2291806982 @default.
• W2897517162 cites W2305551225 @default.
• W2897517162 cites W2396892895 @default.
• W2897517162 cites W2405887092 @default.
• W2897517162 cites W2434441622 @default.
• W2897517162 cites W2552702441 @default.
• W2897517162 cites W2555663947 @default.
• W2897517162 cites W2560636362 @default.
• W2897517162 cites W2593991007 @default.
• W2897517162 cites W2620943675 @default.
• W2897517162 cites W4256394412 @default.
• W2897517162 cites W585687352 @default.
• W2897517162 cites W1964184380 @default.
• W2897517162 doi "https://doi.org/10.3892/mmr.2018.9562" @default.
• W2897517162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6236221" @default.
• W2897517162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30365085" @default.
• W2897517162 hasPublicationYear "2018" @default.
• W2897517162 type Work @default.
• W2897517162 sameAs 2897517162 @default.
• W2897517162 citedByCount "12" @default.
• W2897517162 countsByYear W28975171622019 @default.
• W2897517162 countsByYear W28975171622020 @default.
• W2897517162 countsByYear W28975171622021 @default.
• W2897517162 countsByYear W28975171622022 @default.
• W2897517162 countsByYear W28975171622023 @default.
• W2897517162 crossrefType "journal-article" @default.
• W2897517162 hasAuthorship W2897517162A5004144742 @default.
• W2897517162 hasAuthorship W2897517162A5005082513 @default.
• W2897517162 hasAuthorship W2897517162A5008484454 @default.
• W2897517162 hasAuthorship W2897517162A5008827800 @default.
• W2897517162 hasAuthorship W2897517162A5023461224 @default.
• W2897517162 hasAuthorship W2897517162A5027467135 @default.
• W2897517162 hasAuthorship W2897517162A5028287056 @default.
• W2897517162 hasAuthorship W2897517162A5036233323 @default.
• W2897517162 hasAuthorship W2897517162A5039896971 @default.
• W2897517162 hasAuthorship W2897517162A5048807755 @default.
• W2897517162 hasAuthorship W2897517162A5054439790 @default.
• W2897517162 hasAuthorship W2897517162A5069035178 @default.
• W2897517162 hasAuthorship W2897517162A5070633210 @default.
• W2897517162 hasBestOaLocation W28975171621 @default.
• W2897517162 hasConcept C104317684 @default.
• W2897517162 hasConcept C121608353 @default.
• W2897517162 hasConcept C126322002 @default.
• W2897517162 hasConcept C143998085 @default.
• W2897517162 hasConcept C145059251 @default.
• W2897517162 hasConcept C204232928 @default.

• next