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- W2897517171 endingPage "167" @default.
- W2897517171 startingPage "167" @default.
- W2897517171 abstract "Extracellular vesicles (EVs) are membrane enclosed micro- and nano-sized vesicles that are secreted from almost every species, ranging from prokaryotes to eukaryotes, and from almost every cell type studied so far. EVs contain repertoire of bioactive molecules such as proteins (including enzymes and transcriptional factors), lipids, carbohydrates and nucleic acids including DNA, coding and non-coding RNAs. The secreted EVs are taken up by neighboring cells where they release their content in recipient cells, or can sail through body fluids to reach distant organs. Since EVs transport bioactive cargo between cells, they have emerged as novel mediators of extra- and intercellular activities in local microenvironment and inter-organ communications distantly. Herein, we review the activities of EV-associated matrix-remodeling enzymes such as matrix metalloproteinases, heparanases, hyaluronidases, aggrecanases, and their regulators such as extracellular matrix metalloproteinase inducers and tissue inhibitors of metalloproteinases as novel means of matrix remodeling in physiological and pathological conditions. We discuss how such EVs act as novel mediators of extracellular matrix degradation to prepare a permissive environment for various pathological conditions such as cancer, cardiovascular diseases, arthritis and metabolic diseases. Additionally, the roles of EV-mediated matrix remodeling in tissue repair and their potential applications as organ therapies have been reviewed. Collectively, this knowledge could benefit the development of new approaches for tissue engineering." @default.
- W2897517171 created "2018-10-26" @default.
- W2897517171 creator A5002018700 @default.
- W2897517171 creator A5022690179 @default.
- W2897517171 creator A5033006459 @default.
- W2897517171 creator A5035939107 @default.
- W2897517171 creator A5057943137 @default.
- W2897517171 creator A5077020833 @default.
- W2897517171 creator A5081434966 @default.
- W2897517171 creator A5083527611 @default.
- W2897517171 date "2018-10-13" @default.
- W2897517171 modified "2023-10-16" @default.
- W2897517171 title "Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair" @default.
- W2897517171 cites W1219301472 @default.
- W2897517171 cites W1518690343 @default.
- W2897517171 cites W1601681275 @default.
- W2897517171 cites W1615093431 @default.
- W2897517171 cites W1759129926 @default.
- W2897517171 cites W1825638291 @default.
- W2897517171 cites W1893005658 @default.
- W2897517171 cites W1898690520 @default.
- W2897517171 cites W1950118853 @default.
- W2897517171 cites W1959468401 @default.
- W2897517171 cites W1964232997 @default.
- W2897517171 cites W1967367827 @default.
- W2897517171 cites W1968012290 @default.
- W2897517171 cites W1971546199 @default.
- W2897517171 cites W1975355918 @default.
- W2897517171 cites W1976014845 @default.
- W2897517171 cites W1977799997 @default.
- W2897517171 cites W1978412805 @default.
- W2897517171 cites W1978654717 @default.
- W2897517171 cites W1979568941 @default.
- W2897517171 cites W1980943699 @default.
- W2897517171 cites W1982669563 @default.
- W2897517171 cites W1983752521 @default.
- W2897517171 cites W1985789005 @default.
- W2897517171 cites W1985844219 @default.
- W2897517171 cites W1988327113 @default.
- W2897517171 cites W1989437173 @default.
- W2897517171 cites W1989971125 @default.
- W2897517171 cites W1992352812 @default.
- W2897517171 cites W1996100950 @default.
- W2897517171 cites W1997839825 @default.
- W2897517171 cites W1998569410 @default.
- W2897517171 cites W1999884961 @default.
- W2897517171 cites W2004445848 @default.
- W2897517171 cites W2004849465 @default.
- W2897517171 cites W2015387324 @default.
- W2897517171 cites W2016298881 @default.
- W2897517171 cites W2017644547 @default.
- W2897517171 cites W2017803048 @default.
- W2897517171 cites W2018347222 @default.
- W2897517171 cites W2021861291 @default.
- W2897517171 cites W2022118535 @default.
- W2897517171 cites W2022956911 @default.
- W2897517171 cites W2025258577 @default.
- W2897517171 cites W2029151903 @default.
- W2897517171 cites W2030701238 @default.
- W2897517171 cites W2031430407 @default.
- W2897517171 cites W2033355502 @default.
- W2897517171 cites W2037484272 @default.
- W2897517171 cites W2042198997 @default.
- W2897517171 cites W2043915684 @default.
- W2897517171 cites W2044835152 @default.
- W2897517171 cites W2046011856 @default.
- W2897517171 cites W2047460472 @default.
- W2897517171 cites W2048883725 @default.
- W2897517171 cites W2055313665 @default.
- W2897517171 cites W2057223895 @default.
- W2897517171 cites W2057976918 @default.
- W2897517171 cites W2059031754 @default.
- W2897517171 cites W2061996203 @default.
- W2897517171 cites W2062180415 @default.
- W2897517171 cites W2062649816 @default.
- W2897517171 cites W2063151064 @default.
- W2897517171 cites W2066304642 @default.
- W2897517171 cites W2066523597 @default.
- W2897517171 cites W2068322460 @default.
- W2897517171 cites W2068577277 @default.
- W2897517171 cites W2071128949 @default.
- W2897517171 cites W2071223181 @default.
- W2897517171 cites W2072924272 @default.
- W2897517171 cites W2073882699 @default.
- W2897517171 cites W2074892413 @default.
- W2897517171 cites W2075855948 @default.
- W2897517171 cites W2080876621 @default.
- W2897517171 cites W2080940456 @default.
- W2897517171 cites W2082550836 @default.
- W2897517171 cites W2083225806 @default.
- W2897517171 cites W2084666131 @default.
- W2897517171 cites W2085145003 @default.
- W2897517171 cites W2085505088 @default.
- W2897517171 cites W2091213093 @default.
- W2897517171 cites W2092335849 @default.
- W2897517171 cites W2098259366 @default.
- W2897517171 cites W2103126984 @default.
- W2897517171 cites W2103994324 @default.