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- W2897517988 abstract "The medial temporal lobe atrophy scale (MTA)1 is a 0-to-4 visual rating scale for assessing the degree of hippocampal atrophy. Despite it is widely used due to its ease of employment, to date normative values are still missing. A trained rater, showing an excellent inter-rater agreement (ICC=0.892; 95% CI: 0.723-0.958) with an expert rater, assessed coronal-T1 MR scans of the 936 cognitively healthy persons from the Italian Brain Normative Archive Study2, and provided MTA scores for both hemispheres. Subjects (age: mean±SD: 50.2±14.7; range: 20-84) were selected retrospectively for having MMSE>26 and/or CDR=0. We provided the normative data by age decades based on the percentile distribution, and investigated the correlation between MTA scores and APOE genotype, when the latter was available (56.3%). 50th (green line) and 90th (red line) percentile cut-offs by age ranges. This study provides the first normative values for MTA in the general population. According to the literature, our data suggest the presence of different age-related cut-offs and, thus, the need to consider different thresholds depending on age. References: 1. Scheltens P et al. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992; 55(10):967-972. 2. Galluzzi S et al. The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions. Aging Clin Exp Res. 2009; 21(4-5):266-276." @default.
- W2897517988 created "2018-10-26" @default.
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- W2897517988 date "2018-07-01" @default.
- W2897517988 modified "2023-10-12" @default.
- W2897517988 title "IC‐P‐120: MEDIAL TEMPORAL LOBE ATROPHY SCALE: NORMATIVE VALUES FOR ITALIAN POPULATION" @default.
- W2897517988 doi "https://doi.org/10.1016/j.jalz.2018.06.2186" @default.
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