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• W2897519410 abstract "MiRNA (or microRNA) is a subclass of non-coding RNAs that is responsible for post-transcriptional gene regulation. It has approximately 22 nucleotides and regulates gene expression in plants and animals at the post-transcriptional level, by the cleavage of a target mRNA or by suppression of its translation. Although many of the processes and mechanisms have not yet been fully elucidated, there is a strong association between miRNA expression and several diseases. It is known that miRNAs are expressed in the cardiovascular system, but their role in cardiovascular diseases (CVDs) has not been clearly established. In this non-systematic review of the literature, we first present the definition of miRNAs and their action at the cellular level. Afterward, we discuss the role of miRNAs as circulating biomarkers of CVDs, and then their role in cardiac remodeling and atherosclerosis. Despite the complexity and challenges, it is crucial to identify deregulated miRNAs in CVDs, as it allows a better understanding of underlying cellular and molecular mechanisms and helps in the development of more accurate diagnostic and prognostic circulating biomarkers, and new therapeutic strategies for different stages of CVDs." @default.
• W2897519410 created "2018-10-26" @default.
• W2897519410 creator A5038692192 @default.
• W2897519410 creator A5045501108 @default.
• W2897519410 creator A5057423790 @default.
• W2897519410 creator A5089572601 @default.
• W2897519410 date "2018-01-01" @default.
• W2897519410 modified "2023-10-18" @default.
• W2897519410 title "Role of miRNAs on the Pathophysiology of Cardiovascular Diseases" @default.
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• W2897519410 doi "https://doi.org/10.5935/abc.20180215" @default.
• W2897519410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6248252" @default.
• W2897519410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30484515" @default.
• W2897519410 hasPublicationYear "2018" @default.
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