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- W2897519510 abstract "Abstract Plant derived molecules are gaining importance as an alternative to synthetic drugs for the treatment of cognitive and related disorders. Modulation of cholinesterases, monoamine oxidases and sodium–potassium ATPase activities in brain through phyto-molecules has been found effective in the treatment and management of cognitive disorders. Considering the pleiotropic action of plant secondary metabolites, the present investigation was undertaken to explore neuroprotective activity of the ethanolic and hexane extracts from Cucurbita maxima Duchesne ex Poir (seeds), Caeselpenia bunduc (L.) Roxb (seeds) and Bombax ceiba Linn (flowers). To investigate the neuroprotective activity of these plant extracts, cholinesterases (acetylcholinesterase and butyrylcholinesterase), monoamine oxidase (MAO) and Na+/K+ ATPase activities were estimated. To test if chosen plant extracts have also effect on oxidative stress lipid peroxidation and metal chelating ability were determined in mice brain homogenate. In this investigation the ethanolic and hexane extracts from these plants were able to inhibit the acetylcholinesterase and butyrylcholinesterase (43.32–69.94%), which was comparable to standard drug, donepezil at the concentration of 50 μg/ml. The chromatographic (HPTLC) estimation revealed the maximum presence of quercetin in C. maxima whereas p-coumaric acid and gallic acid were found as major constituents in B. ceiba. In conclusion, the findings of current study provide evidence for the selected plant extracts with potent cholinesterase activity which can be taken as lead for further mechanistic study and also for development of plant based formulation after pre-clinical evaluation." @default.
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- W2897519510 date "2019-01-01" @default.
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- W2897519510 title "Neuroprotective potential of Cucurbita maxima Duchesne ex Poir, Caeselpenia bunduc (L.) Roxb and Bombax ceiba Linn extracts" @default.
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- W2897519510 doi "https://doi.org/10.1016/j.sajb.2018.09.027" @default.
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