FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897521368> ?p ?o ?g. }

• W2897521368 abstract "In cestodiasis, mechanical and molecular contact between the parasite and the host activates the immune response of the host and may result in inflammatory processes, leading to ulceration and intestinal dysfunctions. The aim of the present study was to identify antigenic proteins of the adult cestode Hymenolepis diminuta by subjecting the total protein extracts from adult tapeworms to 2DE immunoblotting (two-dimensional electrophoresis combined with immunoblotting) using sera collected from experimentally infected rats. A total of thirty-six protein spots cross-reacting with the rat sera were identified using LC-MS/MS. As a result, sixty-eight proteins, including certain structural muscle proteins (actin, myosin and paramyosin) and moonlighters (heat shock proteins, kinases, phosphatases and glycolytic enzymes) were identified; most of which were predicted to possess binding and/or catalytic activity required in various metabolic and cellular processes, and reported here as potential antigens of the adult cestode for the first time. As several of these antigens can also be found at the cell surface, the surface-associated proteins were extracted and subjected to in-solution digestion for LC-MS/MS identification (surfaceomics). As a result, a total of 76 proteins were identified, from which 31 proteins, based on 2DE immunoblotting, were predicted to be immunogenic. These included structural proteins actin, myosin and tubulin) and certain moonlighting proteins (heat-shock chaperones) while enzymes with diverse catalytic activities were found as the most dominating group of proteins. Thus, the present study suggests that the H. diminuta somatic proteins exposed to the host possess antigenic properties and belong to variouis groups our findings also suggest that the immune response of the host during the adult cestode infection could be stimulated by diverse mechanisms, involving proteins entering the host body via yet unknown non-classical mechanism(s). In conclusion, the present study shed more light into the complexity of the enteric cestodiasis, and suggests that the H. diminuta somatic proteins exposed to the host possess immunomodulatory functions, and that the immune response of the host is stimulated by diverse mechanisms, involving proteins entering the host body via yet unknown non-classical mechanism(s)." @default.
• W2897521368 created "2018-10-26" @default.
• W2897521368 creator A5000073843 @default.
• W2897521368 creator A5004712329 @default.
• W2897521368 creator A5007844491 @default.
• W2897521368 creator A5020997769 @default.
• W2897521368 creator A5058944779 @default.
• W2897521368 creator A5061044570 @default.
• W2897521368 creator A5074069972 @default.
• W2897521368 creator A5075296200 @default.
• W2897521368 creator A5081294725 @default.
• W2897521368 date "2018-11-12" @default.
• W2897521368 modified "2023-10-18" @default.
• W2897521368 title "Immunoproteomics and Surfaceomics of the Adult Tapeworm Hymenolepis diminuta" @default.
• W2897521368 cites W1522104424 @default.
• W2897521368 cites W1551198368 @default.
• W2897521368 cites W1561166623 @default.
• W2897521368 cites W1798501265 @default.
• W2897521368 cites W1821194973 @default.
• W2897521368 cites W1833602160 @default.
• W2897521368 cites W1961330221 @default.
• W2897521368 cites W1965299712 @default.
• W2897521368 cites W1971450904 @default.
• W2897521368 cites W1973189884 @default.
• W2897521368 cites W1973969783 @default.
• W2897521368 cites W1975792531 @default.
• W2897521368 cites W1978799378 @default.
• W2897521368 cites W1979629723 @default.
• W2897521368 cites W1986347578 @default.
• W2897521368 cites W1988601764 @default.
• W2897521368 cites W1992481454 @default.
• W2897521368 cites W1995962823 @default.
• W2897521368 cites W1996972314 @default.
• W2897521368 cites W1998134692 @default.
• W2897521368 cites W2000932279 @default.
• W2897521368 cites W2001236380 @default.
• W2897521368 cites W2003574208 @default.
• W2897521368 cites W2007059700 @default.
• W2897521368 cites W2009693511 @default.
• W2897521368 cites W2012728562 @default.
• W2897521368 cites W2019605417 @default.
• W2897521368 cites W2036295062 @default.
• W2897521368 cites W2039377380 @default.
• W2897521368 cites W2048007675 @default.
• W2897521368 cites W2051580736 @default.
• W2897521368 cites W2061555990 @default.
• W2897521368 cites W2070686097 @default.
• W2897521368 cites W2072294388 @default.
• W2897521368 cites W2076446879 @default.
• W2897521368 cites W2076866396 @default.
• W2897521368 cites W2083508881 @default.
• W2897521368 cites W2091790046 @default.
• W2897521368 cites W2101291993 @default.
• W2897521368 cites W2112050326 @default.
• W2897521368 cites W2113893134 @default.
• W2897521368 cites W2115816614 @default.
• W2897521368 cites W2116894012 @default.
• W2897521368 cites W2119201072 @default.
• W2897521368 cites W2119899991 @default.
• W2897521368 cites W2127230256 @default.
• W2897521368 cites W2131738042 @default.
• W2897521368 cites W2135284380 @default.
• W2897521368 cites W2137425057 @default.
• W2897521368 cites W2138947021 @default.
• W2897521368 cites W2146073125 @default.
• W2897521368 cites W2162641825 @default.
• W2897521368 cites W2167122047 @default.
• W2897521368 cites W2188611891 @default.
• W2897521368 cites W2320624220 @default.
• W2897521368 cites W2330349396 @default.
• W2897521368 cites W2338095278 @default.
• W2897521368 cites W2342275754 @default.
• W2897521368 cites W2482940985 @default.
• W2897521368 cites W2485004164 @default.
• W2897521368 cites W2531300234 @default.
• W2897521368 cites W2547407551 @default.
• W2897521368 cites W2588276054 @default.
• W2897521368 cites W2588683809 @default.
• W2897521368 cites W2607665808 @default.
• W2897521368 cites W2609207099 @default.
• W2897521368 cites W2726562221 @default.
• W2897521368 cites W2729359169 @default.
• W2897521368 cites W2743219009 @default.
• W2897521368 cites W2767591791 @default.
• W2897521368 cites W2769940034 @default.
• W2897521368 cites W2770362391 @default.
• W2897521368 cites W2782099859 @default.
• W2897521368 cites W2782839367 @default.
• W2897521368 cites W2800720711 @default.
• W2897521368 cites W2886124131 @default.
• W2897521368 cites W4247317037 @default.
• W2897521368 cites W4249360254 @default.
• W2897521368 doi "https://doi.org/10.3389/fimmu.2018.02487" @default.
• W2897521368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6240649" @default.
• W2897521368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30483248" @default.
• W2897521368 hasPublicationYear "2018" @default.
• W2897521368 type Work @default.
• W2897521368 sameAs 2897521368 @default.
• W2897521368 citedByCount "22" @default.
• W2897521368 countsByYear W28975213682019 @default.

• next