FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897523083> ?p ?o ?g. }

• W2897523083 endingPage "48" @default.
• W2897523083 startingPage "39" @default.
• W2897523083 abstract "Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder. Selective serotonin reuptake inhibitors (SSRIs) are the first line of medication for OCD treatment; however, 40%-60% of patients with OCD do not respond to SSRIs adequately. There are growing pieces of evidence which suggest a significant role for the glutamatergic system in the genesis of OCD and its consequent treatment. In the present study, we aimed to assess the association of SLC1A1 polymorphisms (rs301430, rs2228622 and rs3780413) with OCD and its clinical characteristics, as well as the importance of these SNPs in the response of OCD patients to SSRI pharmacotherapy.Sample study consisted of 243 OCD cases and 221 control subjects. Patients were treated 12 weeks with fluvoxamine (daily dose: 150-300 mg). Based on the reduction in obsessive and compulsive severity scores using Y-BOCS severity scale, patients were classified as responders, non-responders and refractory. A total of 239, 228 and 215 patients were genotyped for rs301430, rs2228622 and rs3780413, respectively, by the means of PCR-RFLP.No association was detected between SLC1A1 SNPs and OCD, except an association between the familial form of the disease in males with rs2228622 (P = 0.033). The results of pharmacogenetic studies revealed the associations of two SLC1A1 SNPs, rs2228622 (P = 0.031) and rs3780413 (P = 0.008), with treatment response.Results of the current study suggest a role for the glutamate transporter in OCD treatment response with SSRIs which should encourage researchers to further investigate the importance of glutamate transporter in OCD pharmacogenetics." @default.
• W2897523083 created "2018-10-26" @default.
• W2897523083 creator A5001457493 @default.
• W2897523083 creator A5014098779 @default.
• W2897523083 creator A5035509516 @default.
• W2897523083 creator A5046466740 @default.
• W2897523083 creator A5048726037 @default.
• W2897523083 date "2018-10-12" @default.
• W2897523083 modified "2023-09-27" @default.
• W2897523083 title "Genetic and pharmacogenetic study of glutamate transporter (SLC1A1) in Iranian patients with obsessive-compulsive disorder" @default.
• W2897523083 cites W146358134 @default.
• W2897523083 cites W1940768752 @default.
• W2897523083 cites W1969063946 @default.
• W2897523083 cites W1970731671 @default.
• W2897523083 cites W1972161610 @default.
• W2897523083 cites W1973748621 @default.
• W2897523083 cites W1974537105 @default.
• W2897523083 cites W1982836089 @default.
• W2897523083 cites W1984170477 @default.
• W2897523083 cites W1991538811 @default.
• W2897523083 cites W2007846729 @default.
• W2897523083 cites W2031780513 @default.
• W2897523083 cites W2032360884 @default.
• W2897523083 cites W2034482154 @default.
• W2897523083 cites W2065020592 @default.
• W2897523083 cites W2078966869 @default.
• W2897523083 cites W2087854982 @default.
• W2897523083 cites W2097386588 @default.
• W2897523083 cites W2099611631 @default.
• W2897523083 cites W2104264813 @default.
• W2897523083 cites W2105697752 @default.
• W2897523083 cites W2127775244 @default.
• W2897523083 cites W2129581943 @default.
• W2897523083 cites W2133479741 @default.
• W2897523083 cites W2143027421 @default.
• W2897523083 cites W2154076220 @default.
• W2897523083 cites W2164415474 @default.
• W2897523083 cites W2618944769 @default.
• W2897523083 cites W2781731994 @default.
• W2897523083 doi "https://doi.org/10.1111/jcpt.12766" @default.
• W2897523083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315580" @default.
• W2897523083 hasPublicationYear "2018" @default.
• W2897523083 type Work @default.
• W2897523083 sameAs 2897523083 @default.
• W2897523083 citedByCount "12" @default.
• W2897523083 countsByYear W28975230832019 @default.
• W2897523083 countsByYear W28975230832020 @default.
• W2897523083 countsByYear W28975230832021 @default.
• W2897523083 countsByYear W28975230832022 @default.
• W2897523083 countsByYear W28975230832023 @default.
• W2897523083 crossrefType "journal-article" @default.
• W2897523083 hasAuthorship W2897523083A5001457493 @default.
• W2897523083 hasAuthorship W2897523083A5014098779 @default.
• W2897523083 hasAuthorship W2897523083A5035509516 @default.
• W2897523083 hasAuthorship W2897523083A5046466740 @default.
• W2897523083 hasAuthorship W2897523083A5048726037 @default.
• W2897523083 hasBestOaLocation W28975230831 @default.
• W2897523083 hasConcept C104317684 @default.
• W2897523083 hasConcept C118552586 @default.
• W2897523083 hasConcept C126322002 @default.
• W2897523083 hasConcept C135763542 @default.
• W2897523083 hasConcept C153209595 @default.
• W2897523083 hasConcept C170493617 @default.
• W2897523083 hasConcept C2775864247 @default.
• W2897523083 hasConcept C2776134451 @default.
• W2897523083 hasConcept C2778897192 @default.
• W2897523083 hasConcept C2779177272 @default.
• W2897523083 hasConcept C2779910183 @default.
• W2897523083 hasConcept C31487548 @default.
• W2897523083 hasConcept C54355233 @default.
• W2897523083 hasConcept C55775858 @default.
• W2897523083 hasConcept C558461103 @default.
• W2897523083 hasConcept C71924100 @default.
• W2897523083 hasConcept C86803240 @default.
• W2897523083 hasConcept C98274493 @default.
• W2897523083 hasConceptScore W2897523083C104317684 @default.
• W2897523083 hasConceptScore W2897523083C118552586 @default.
• W2897523083 hasConceptScore W2897523083C126322002 @default.
• W2897523083 hasConceptScore W2897523083C135763542 @default.
• W2897523083 hasConceptScore W2897523083C153209595 @default.
• W2897523083 hasConceptScore W2897523083C170493617 @default.
• W2897523083 hasConceptScore W2897523083C2775864247 @default.
• W2897523083 hasConceptScore W2897523083C2776134451 @default.
• W2897523083 hasConceptScore W2897523083C2778897192 @default.
• W2897523083 hasConceptScore W2897523083C2779177272 @default.
• W2897523083 hasConceptScore W2897523083C2779910183 @default.
• W2897523083 hasConceptScore W2897523083C31487548 @default.
• W2897523083 hasConceptScore W2897523083C54355233 @default.
• W2897523083 hasConceptScore W2897523083C55775858 @default.
• W2897523083 hasConceptScore W2897523083C558461103 @default.
• W2897523083 hasConceptScore W2897523083C71924100 @default.
• W2897523083 hasConceptScore W2897523083C86803240 @default.
• W2897523083 hasConceptScore W2897523083C98274493 @default.
• W2897523083 hasFunder F4320323457 @default.
• W2897523083 hasIssue "1" @default.
• W2897523083 hasLocation W28975230831 @default.
• W2897523083 hasLocation W28975230832 @default.
• W2897523083 hasOpenAccess W2897523083 @default.

• next