FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897524250> ?p ?o ?g. }

• W2897524250 endingPage "3447" @default.
• W2897524250 startingPage "3439" @default.
• W2897524250 abstract "MicroRNAs (miRNA) are a class of small, highly conserved noncoding RNA molecules, which contain 18-28 nucleotides and are involved in the regulation of gene expression. It has been proved that microRNAs play a very important role in several key cellular processes, such as cell differentiation, cell cycle progression, and apoptosis, as well as in autoimmune disease. One recently identified miRNA, miR-708-5p, has been demonstrated to have profound roles in suppressing oncogenesis in different types of tumors. However, the role of miR-708-5p in rheumatoid arthritis (RA) remains to be fully elucidated. Therefore, in this study, we are aiming to identify the role of miR-708-5p in RA.The expression level of miR-708-5p in synovial tissues of patients with RA is much lower than in non-RA controls. The effects of miR-708-5p on cell apoptosis, colony formation, and migration in fibroblast-like synoviocytes were assessed in MH7A cells.Results showed that delivery of miR-708-5p mimics into synovial fibroblasts MH7A could induce cell apoptosis and inhibit colony formation and migration. In addition, miR-708-5p mimics significantly inhibit Wnt3a/β-catenin pathway activity both in transcription and protein level, which could be reversed by the addition of R-spondin 1, an activator of Wnt pathway. R-spondin 1 could also reverse the inhibition of cell survival and proliferation, which was induced by miR-708-5p mimics in MH7A. Moreover, injection of miR-708-5p mimics into collagen-induced rat RA model could ameliorate the RA index and decrease Wnt3a/β-catenin expression in rat joint tissues.Therefore, we concluded that miR-708-5p is likely to be involved in RA pathogenesis via inhibition of Wnt3a/β-catenin pathway." @default.
• W2897524250 created "2018-10-26" @default.
• W2897524250 creator A5007734557 @default.
• W2897524250 creator A5024084937 @default.
• W2897524250 creator A5053809618 @default.
• W2897524250 creator A5067837196 @default.
• W2897524250 date "2018-10-01" @default.
• W2897524250 modified "2023-10-12" @default.
• W2897524250 title "miR-708-5p promotes fibroblast&ndash;like synoviocytes&#39; cell apoptosis and ameliorates rheumatoid arthritis by inhibition of Wnt3a/&beta;-catenin pathway" @default.
• W2897524250 cites W14098964 @default.
• W2897524250 cites W1494266908 @default.
• W2897524250 cites W1963819880 @default.
• W2897524250 cites W1981466349 @default.
• W2897524250 cites W1987562346 @default.
• W2897524250 cites W1990857807 @default.
• W2897524250 cites W1992032030 @default.
• W2897524250 cites W1996575556 @default.
• W2897524250 cites W2017762858 @default.
• W2897524250 cites W2022025395 @default.
• W2897524250 cites W2030844903 @default.
• W2897524250 cites W2036615406 @default.
• W2897524250 cites W2074438676 @default.
• W2897524250 cites W2096388504 @default.
• W2897524250 cites W2109869603 @default.
• W2897524250 cites W2110604741 @default.
• W2897524250 cites W2112785261 @default.
• W2897524250 cites W2118343231 @default.
• W2897524250 cites W2127669794 @default.
• W2897524250 cites W2131882149 @default.
• W2897524250 cites W2215660606 @default.
• W2897524250 cites W2795037955 @default.
• W2897524250 cites W4253796858 @default.
• W2897524250 cites W750760073 @default.
• W2897524250 doi "https://doi.org/10.2147/dddt.s177128" @default.
• W2897524250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6186895" @default.
• W2897524250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30349197" @default.
• W2897524250 hasPublicationYear "2018" @default.
• W2897524250 type Work @default.
• W2897524250 sameAs 2897524250 @default.
• W2897524250 citedByCount "39" @default.
• W2897524250 countsByYear W28975242502019 @default.
• W2897524250 countsByYear W28975242502020 @default.
• W2897524250 countsByYear W28975242502021 @default.
• W2897524250 countsByYear W28975242502022 @default.
• W2897524250 countsByYear W28975242502023 @default.
• W2897524250 crossrefType "journal-article" @default.
• W2897524250 hasAuthorship W2897524250A5007734557 @default.
• W2897524250 hasAuthorship W2897524250A5024084937 @default.
• W2897524250 hasAuthorship W2897524250A5053809618 @default.
• W2897524250 hasAuthorship W2897524250A5067837196 @default.
• W2897524250 hasBestOaLocation W28975242501 @default.
• W2897524250 hasConcept C104317684 @default.
• W2897524250 hasConcept C137620995 @default.
• W2897524250 hasConcept C137738243 @default.
• W2897524250 hasConcept C145059251 @default.
• W2897524250 hasConcept C1491633281 @default.
• W2897524250 hasConcept C170493617 @default.
• W2897524250 hasConcept C185592680 @default.
• W2897524250 hasConcept C190283241 @default.
• W2897524250 hasConcept C202751555 @default.
• W2897524250 hasConcept C2780381497 @default.
• W2897524250 hasConcept C29537977 @default.
• W2897524250 hasConcept C502942594 @default.
• W2897524250 hasConcept C55493867 @default.
• W2897524250 hasConcept C62112901 @default.
• W2897524250 hasConcept C62478195 @default.
• W2897524250 hasConcept C86803240 @default.
• W2897524250 hasConcept C88045685 @default.
• W2897524250 hasConcept C95444343 @default.
• W2897524250 hasConceptScore W2897524250C104317684 @default.
• W2897524250 hasConceptScore W2897524250C137620995 @default.
• W2897524250 hasConceptScore W2897524250C137738243 @default.
• W2897524250 hasConceptScore W2897524250C145059251 @default.
• W2897524250 hasConceptScore W2897524250C1491633281 @default.
• W2897524250 hasConceptScore W2897524250C170493617 @default.
• W2897524250 hasConceptScore W2897524250C185592680 @default.
• W2897524250 hasConceptScore W2897524250C190283241 @default.
• W2897524250 hasConceptScore W2897524250C202751555 @default.
• W2897524250 hasConceptScore W2897524250C2780381497 @default.
• W2897524250 hasConceptScore W2897524250C29537977 @default.
• W2897524250 hasConceptScore W2897524250C502942594 @default.
• W2897524250 hasConceptScore W2897524250C55493867 @default.
• W2897524250 hasConceptScore W2897524250C62112901 @default.
• W2897524250 hasConceptScore W2897524250C62478195 @default.
• W2897524250 hasConceptScore W2897524250C86803240 @default.
• W2897524250 hasConceptScore W2897524250C88045685 @default.
• W2897524250 hasConceptScore W2897524250C95444343 @default.
• W2897524250 hasLocation W28975242501 @default.
• W2897524250 hasLocation W28975242502 @default.
• W2897524250 hasLocation W28975242503 @default.
• W2897524250 hasLocation W28975242504 @default.
• W2897524250 hasOpenAccess W2897524250 @default.
• W2897524250 hasPrimaryLocation W28975242501 @default.
• W2897524250 hasRelatedWork W2350294409 @default.
• W2897524250 hasRelatedWork W2350542818 @default.
• W2897524250 hasRelatedWork W2354128257 @default.
• W2897524250 hasRelatedWork W2354735832 @default.
• W2897524250 hasRelatedWork W2365530377 @default.

• next